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Experimental & Translational Stroke Medicine

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Open Access 01-12-2012 | Short report

Photochemically induced ischemic stroke in rats

Authors: Antje Schmidt, Maike Hoppen, Jan-Kolja Strecker, Kai Diederich, Wolf-Rüdiger Schäbitz, Matthias Schilling, Jens Minnerup

Published in: Experimental & Translational Stroke Medicine | Issue 1/2012

Abstract

Background

Photothrombosis was introduced as a model of ischemic stroke by Watson et al. in 1985. In the present paper, we describe a protocol to induce photothrombotic infarcts in rats.

Findings

The photosensitive dye Bengal Rose is intravenously administered and a laser beam is stereotactically positioned onto the skull. Illumination through the intact skull leads to local activation of Bengal Rose, which results in free radical formation, disturbance of endothelial function and thrombus formation in illuminated small cortical vessels.

Conclusions

Photochemically induced infarcts cause long-term sensorimotor deficits, allow long-term survival and are particularly suitable to assess the effectiveness of neuroregenerative therapies in chronic stroke studies.

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Title: Photochemically induced ischemic stroke in rats
Authors: Antje Schmidt
Maike Hoppen
Jan-Kolja Strecker
Kai Diederich
Wolf-Rüdiger Schäbitz
Matthias Schilling
Jens Minnerup
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2012
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-4-13

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Photochemically induced ischemic stroke in rats

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusions

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