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Experimental & Translational Stroke Medicine

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Open Access 01-12-2011 | Research

Platelet glycoprotein Ibα is an important mediator of ischemic stroke in mice

Authors: Simon F De Meyer, Tobias Schwarz, Daphne Schatzberg, Denisa D Wagner

Published in: Experimental & Translational Stroke Medicine | Issue 1/2011

Abstract

Background

Platelets play an important role in ischemic stroke. GPIbα is a major platelet receptor that is critical for platelet adhesion to exposed subendothelial matrix components at sites of vascular damage.

Methods

In this study, we used transgenic mice in which the extracellular part of GPIbα is replaced by human interleukin 4-receptor (GPIbα/IL4Rα). We observed normal brain vasculature in these mice. We compared infarct size in GPIbα/IL4Rα and wild-type (WT) mice 23 hours after 1-hour transient middle cerebral artery occlusion (tMCAO). In addition, the functional outcome was evaluated using a modified Bederson score.

Results

We found a significantly smaller infarct size in GPIbα/IL4Rα mice compared to WT mice (38.0 ± 6.5 mm³ vs. 74.2 ± 8.6 mm³, p < 0.001). The decrease in infarct size was functionally relevant as indicated by a significantly better functional Bederson score in GPIbα/IL4Rα mice compared to WT animals (1.3 ± 0.4 vs. 2.7 ± 0.3, p < 0.05).

Conclusions

Our data illustrate and further confirm the important role of platelet GPIbα in ischemic stroke, suggesting that targeted inhibition of this receptor may open new avenues in stroke treatment.

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Title: Platelet glycoprotein Ibα is an important mediator of ischemic stroke in mice
Authors: Simon F De Meyer
Tobias Schwarz
Daphne Schatzberg
Denisa D Wagner
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2011
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-3-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Platelet glycoprotein Ibα is an important mediator of ischemic stroke in mice

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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