Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Molecular Autism
Published in: Molecular Autism 1/2014

Open Access 01-12-2014 | Research

The role of mirroring and mentalizing networks in mediating action intentions in autism

Authors: Lauren E Libero, Jose O Maximo, Hrishikesh D Deshpande, Laura G Klinger, Mark R Klinger, Rajesh K Kana

Published in: Molecular Autism | Issue 1/2014

Login to get access

Abstract

Background

The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in attributing intentions to others. The present study investigated the neural mechanisms of inferring intentions from actions in individuals with ASD.

Methods

Functional magnetic resonance imaging (fMRI) data were acquired from 21 high-functioning young adults with ASD and 22 typically developing (TD) control participants, while making judgments about the means (how an action is performed) and intention (why an action is performed) of a model’s actions.

Results

Across both groups of participants, the middle and superior temporal cortex, extending to temporoparietal junction, and posterior cingulate cortex, responded significantly to inferring the intent of an action, while inferior parietal lobule and occipital cortices were active for judgments about the means of an action. Participants with ASD had significantly reduced activation in calcarine sulcus and significantly increased activation in left inferior frontal gyrus, compared to TD peers, while attending to the intentions of actions. Also, ASD participants had weaker functional connectivity between frontal and posterior temporal regions while processing intentions.

Conclusions

These results suggest that processing actions and intentions may not be mutually exclusive, with reliance on mirroring and mentalizing mechanisms mediating action understanding. Overall, inferring information about others’ actions involves activation of the mirror neuron system and theory-of-mind regions, and this activation (and the synchrony between activated brain regions) appears altered in young adults with ASD.
Appendix
Available only for authorised users
Literature
1.
Thioux M, Gazzola V, Keysers C: Action understanding: how, what and why. Curr Biol. 2008, 18: R431-R434. 10.1016/j.cub.2008.03.018.CrossRefPubMed
2.
Gallese V, Goldman A: Mirror neurons and the simulation theory of mind-reading. Trends Cogn Sci. 1998, 2: 493-501. 10.1016/S1364-6613(98)01262-5.CrossRefPubMed
3.
Gordon RM: Folk psychology as simulation. Mind Lang. 1986, 1: 158-171. 10.1111/j.1468-0017.1986.tb00324.x.CrossRef
4.
Heal J: Replication and functionalism. 1986, New York, NY: Cambridge University Press
5.
Avikainen S, Forss N, Hari R: Modulated activation of the human SI and SII cortices during observation of hand actions. Neuroimage. 2002, 15: 640-646. 10.1006/nimg.2001.1029.CrossRefPubMed
6.
Gazzola V, Aziz-Zadeh L, Keysers C: Empathy and the somatotopic auditory mirror system in humans. Curr Biol. 2006, 16: 1824-1829. 10.1016/j.cub.2006.07.072.CrossRefPubMed
7.
Gazzola V, Rizzolatti G, Wicker B, Keysers C: The anthropomorphic brain: the mirror neuron system responds to human and robotic actions. Neuroimage. 2007, 35: 1674-1684. 10.1016/j.neuroimage.2007.02.003.CrossRefPubMed
8.
Gallese V, Fadiga L, Fogassi L, Rizzolatti G: Action recognition in the premotor cortex. Brain. 1996, 119: 593-609. 10.1093/brain/119.2.593.CrossRefPubMed
9.
Gallese V, Keysers C, Rizzolatti G: A unifying view of the basis of social cognition. Trends Cogn Sci. 2004, 8: 396-403. 10.1016/j.tics.2004.07.002.CrossRefPubMed
10.
Keysers C, Kohler E, Umiltà MA, Nanetti L, Fogassi L, Gallese V: Audiovisual mirror neurons and action recognition. Exp Brain Res. 2003, 153: 628-636. 10.1007/s00221-003-1603-5.CrossRefPubMed
11.
Kohler E, Keysers C, Umilta MA, Fogassi L, Gallese V, Rizzolatti G: Hearing sounds, understanding actions: action representation in mirror neurons. Science. 2002, 297: 846-848. 10.1126/science.1070311.CrossRefPubMed
12.
Rizzolatti G, Fadiga L, Matelli M, Bettinardi V, Paulesu E, Perani D, Fazio F: Localization of grasp representations in humans by PET: 1. Observation versus execution. Exp Brain Res. 1996, 111: 246-252.CrossRefPubMed
13.
Grafton ST, Hamilton AF d C: Evidence for a distributed hierarchy of action representation in the brain. Hum Mov Sci. 2007, 26: 590-616. 10.1016/j.humov.2007.05.009.PubMedCentralCrossRefPubMed
14.
Hari R, Forss N, Avikainen S, Kirveskari E, Salenius S, Rizzolatti G: Activation of human primary motor cortex during action observation: a neuromagnetic study. Proc Natl Acad Sci. 1998, 95: 15061-15065. 10.1073/pnas.95.25.15061.PubMedCentralCrossRefPubMed
15.
Rizzolatti G, Fadiga L: Grasping objects and grasping action meanings: the dual role of monkey rostroventral premotor cortex (area F5). Novartis Found Symp. 1998, 218: 81-95. discussion 95–103PubMed
16.
Keysers C, Gazzola V: Integrating simulation and theory of mind: from self to social cognition. Trends Cogn Sci. 2007, 11: 194-196. 10.1016/j.tics.2007.02.002.CrossRefPubMed
17.
Uddin LQ, Iacoboni M, Lange C, Keenan JP: The self and social cognition: the role of cortical midline structures and mirror neurons. Trends Cogn Sci. 2007, 11: 153-157. 10.1016/j.tics.2007.01.001.CrossRefPubMed
18.
de Lange FP, Spronk M, Willems RM, Toni I, Bekkering H: Complementary systems for understanding action intentions. CB. 2008, 18: 454-457.PubMed
19.
Fletcher PC, Happe F, Frith U, Baker SC, Dolan RJ, Frackowiak RS, Frith CD: Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension. Cognition. 1995, 57: 109-128. 10.1016/0010-0277(95)00692-R.CrossRefPubMed
20.
Gallagher HL, Happe F, Brunswick N, Fletcher PC, Frith U, Frith CD: Reading the mind in cartoons and stories: an fMRI study of “theory of mind” in verbal and nonverbal tasks. Neuropsychologia. 2000, 38: 11-21. 10.1016/S0028-3932(99)00053-6.CrossRefPubMed
21.
Ruby P, Decety J: What you believe versus what you think they believe: a neuroimaging study of conceptual perspective taking. Eur J Neurosci. 2003, 17: 2475-2480. 10.1046/j.1460-9568.2003.02673.x.CrossRefPubMed
22.
Saxe R, Kanwisher N: People thinking about thinking people: the role of the temporo-parietal junction in “theory of mind”. Neuroimage. 2003, 19: 1835-1842. 10.1016/S1053-8119(03)00230-1.CrossRefPubMed
23.
Vogeley K, Bussfeld P, Newen A, Herrmann S, Happe F, Falkai P, Maier W, Shah N, Fink G, Zilles K: Mind reading: neural mechanisms of theory of mind and self-perspective. Neuroimage. 2001, 14: 170-181. 10.1006/nimg.2001.0789.CrossRefPubMed
24.
Van Overwalle F, Baetens K: Understanding others’ actions and goals by mirror and mentalizing systems: a meta-analysis. Neuroimage. 2009, 48: 564-584. 10.1016/j.neuroimage.2009.06.009.CrossRefPubMed
25.
Spunt RP, Falk EB, Lieberman MD: Dissociable neural systems support retrieval of how and why action knowledge. Psychol Sci. 2010, 21: 1593-1598. 10.1177/0956797610386618.CrossRefPubMed
26.
Baron-Cohen S, Leslie AM, Frith U: Does the autistic child have a “theory of mind”?. Cognition. 1985, 21: 37-46. 10.1016/0010-0277(85)90022-8.CrossRefPubMed
27.
Baron-Cohen S: Mindblindness: An essay on autism and theory of mind. 1995, Cambridge, MA: Bradford: MIT Press
28.
Happé F, Frith U: The neuropsychology of autism. Brain. 1996, 119: 1377-1400. 10.1093/brain/119.4.1377.CrossRefPubMed
29.
Williams JH, Waiter GD, Gilchrist A, Perrett DI, Murray AD, Whiten A: Neural mechanisms of imitation and ‘mirror neuron’functioning in autistic spectrum disorder. Neuropsychologia. 2006, 44: 610-621. 10.1016/j.neuropsychologia.2005.06.010.CrossRefPubMed
30.
Meltzoff AN, Gopnik A: The role of imitation in understanding persons and developing a theory of mind. Understanding other minds: Perspectives from autism. Edited by: Baron-Cohen S, Tager-Flusburg E. 1993, Cohen, D. New York, NY: Oxford University Press, 335-366.
31.
Rogers SJ, Pennington BF: A theoretical approach to the deficits in infantile autism. Dev Psychopathol. 1991, 3: 137-162. 10.1017/S0954579400000043.CrossRef
32.
Rogers SJ: An examination of the imitation deficit in autism. 1999, New York, NY: Cambridge University Press
33.
Smith IM, Bryson SE: Imitation and action in autism: a critical review. Psychol Bull. 1994, 116: 259-CrossRefPubMed
34.
Heiser M, Iacoboni M, Maeda F, Marcus J, Mazziotta JC: The essential role of Broca’s area in imitation. Eur J Neurosci. 2003, 17: 1123-1128. 10.1046/j.1460-9568.2003.02530.x.CrossRefPubMed
35.
Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G: Cortical mechanisms of human imitation. Science. 1999, 286: 2526-2528. 10.1126/science.286.5449.2526.CrossRefPubMed
36.
Iacoboni M, Dapretto M: The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci. 2006, 7: 942-951. 10.1038/nrn2024.CrossRefPubMed
37.
Koski L, Wohlschläger A, Bekkering H, Woods RP, Dubeau M-C, Mazziotta JC, Iacoboni M: Modulation of motor and premotor activity during imitation of target-directed actions. Cereb Cortex. 2002, 12: 847-855. 10.1093/cercor/12.8.847.CrossRefPubMed
38.
Koski L, Iacoboni M, Dubeau M-C, Woods RP, Mazziotta JC: Modulation of cortical activity during different imitative behaviors. J Neurophysiol. 2003, 89: 460-471.CrossRefPubMed
39.
Oberman LM, Ramachandran VS: The simulating social mind: the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders. Psychol Bull. 2007, 133: 310-CrossRefPubMed
40.
Oberman LM, Hubbard EM, McCleery JP, Altschuler EL, Ramachandran VS, Pineda JA: EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cogn Brain Res. 2005, 24: 190-198. 10.1016/j.cogbrainres.2005.01.014.CrossRef
41.
Kana RK, Libero LE, Hu CP, Deshpande HD, Colburn JS: Functional brain networks and white matter underlying theory-of-mind in autism. Soc Cogn Affect Neurosci. 2014, 9: 98-105. 10.1093/scan/nss106.PubMedCentralCrossRefPubMed
42.
Cattaneo L, Fabbri-Destro M, Boria S, Pieraccini C, Monti A, Cossu G, Rizzolatti G: Impairment of actions chains in autism and its possible role in intention understanding. Proc Natl Acad Sci. 2007, 104: 17825-17830. 10.1073/pnas.0706273104.PubMedCentralCrossRefPubMed
43.
Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, Iacoboni M: Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 2005, 9: 28-30.PubMedCentralCrossRefPubMed
44.
Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H: Anatomical differences in the mirror neuron system and social cognition network in autism. Cereb Cortex. 2006, 16: 1276-CrossRefPubMed
45.
Gallese V: Intentional attunement: a neurophysiological perspective on social cognition and its disruption in autism. Brain Res. 2006, 1079: 15-24. 10.1016/j.brainres.2006.01.054.CrossRefPubMed
46.
Martineau J, Andersson F, Barthélémy C, Cottier J-P, Destrieux C: Atypical activation of the mirror neuron system during perception of hand motion in autism. Brain Res. 2010, 1320: 168-175.CrossRefPubMed
47.
Hamilton AFC: Reflecting on the mirror neuron system in autism: a systematic review of current theories. Dev Cogn Neurosci. 2013, 3: 91-105.CrossRefPubMed
48.
Bernier R, Dawson G: The role of mirror neuron dysfunction in autism. Mirror Neuron Systems. 2009, Heidelberg: Springer, 261-286.
49.
Kana RK, Wadsworth HM, Travers BG: A systems level analysis of the mirror neuron hypothesis and imitation impairments in autism spectrum disorders. Neurosci Biobehav Rev. 2011, 35: 894-902. 10.1016/j.neubiorev.2010.10.007.CrossRefPubMed
50.
Williams JH: Self–other relations in social development and autism: multiple roles for mirror neurons and other brain bases. Autism Res. 2008, 1: 73-90. 10.1002/aur.15.CrossRefPubMed
51.
Avikainen S, Kulomäki T, Hari R: Normal movement reading in Asperger subjects. Neuroreport. 1999, 10: 3467-3470. 10.1097/00001756-199911260-00001.CrossRefPubMed
52.
53.
Raymaekers R, Wiersema JR, Roeyers H: EEG study of the mirror neuron system in children with high functioning autism. Brain Res. 2009, 1304: 113-121.CrossRefPubMed
54.
Hamilton AFC, Brindley RM, Frith U: Imitation and action understanding in autistic spectrum disorders: how valid is the hypothesis of a deficit in the mirror neuron system?. Neuropsychologia. 2007, 45: 1859-1868. 10.1016/j.neuropsychologia.2006.11.022.CrossRefPubMed
55.
Southgate V, Hamilton AFDC: Unbroken mirrors: challenging a theory of autism. Trends Cogn Sci. 2008, 12: 225-229. 10.1016/j.tics.2008.03.005.CrossRefPubMed
56.
Dinstein I, Thomas C, Humphreys K, Minshew N, Behrmann M, Heeger DJ: Normal movement selectivity in autism. Neuron. 2010, 66: 461-469. 10.1016/j.neuron.2010.03.034.PubMedCentralCrossRefPubMed
57.
Castelli F, Frith C, Happé F, Frith U: Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain. 2002, 125: 1839-1849. 10.1093/brain/awf189.CrossRefPubMed
58.
Kana RK, Keller TA, Cherkassky VL, Minshew NJ, Just MA: Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution. Soc Neurosci. 2009, 4: 135-152. 10.1080/17470910802198510.PubMedCentralCrossRefPubMed
59.
Pelphrey K, Adolphs R, Morris JP: Neuroanatomical substrates of social cognition dysfunction in autism. Ment Retard Dev Disabil Res Rev. 2004, 10: 259-271. 10.1002/mrdd.20040.CrossRefPubMed
60.
Kana RK, Libero LE, Moore MS: Disrupted cortical connectivity theory as an explanatory model for autism spectrum disorders. Phys Life Rev. 2011, 8: 410-437. 10.1016/j.plrev.2011.10.001.CrossRefPubMed
61.
Just MA, Keller TA, Malave VL, Kana RK, Varma S: Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity. Neurosci Biobehav Rev. 2012, 36: 1292-1313. 10.1016/j.neubiorev.2012.02.007.PubMedCentralCrossRefPubMed
62.
Schipul SE, Keller TA, Just MA: Inter-regional brain communication and its disturbance in autism. Front Syst Neurosci. 2011, 5: 7-CrossRef
63.
Maximo JO, Cadena EJ, Kana RK: The implications of brain connectivity in the neuropsychology of autism. Neuropsychol Rev. 2014, 24: 16-31. 10.1007/s11065-014-9250-0.PubMedCentralCrossRefPubMed
64.
Wechsler D: Wechsler abbreviated scale of intelligence. 1999, San Antonio, TX: Psychological Corporation
65.
Oldfield RC: The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971, 9: 97-113. 10.1016/0028-3932(71)90067-4.CrossRefPubMed
66.
Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I: The “Reading the Mind in the Eyes” Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry. 2001, 42: 241-251. 10.1111/1469-7610.00715.CrossRefPubMed
67.
Ritvo RA, Ritvo ER, Guthrie D, Ritvo MJ, Hufnagel DH, McMahon W, Tonge B, Mataix-Cols D, Jassi A, Attwood T: The Ritvo Autism asperger diagnostic scale-revised (RAADS-R): a scale to assist the diagnosis of Autism spectrum disorder in adults: an international validation study. J Autism Dev Disord. 2011, 41: 1076-1089. 10.1007/s10803-010-1133-5.PubMedCentralCrossRefPubMed
68.
Baron-Cohen S, Wheelwright S: The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord. 2004, 34: 163-175.CrossRefPubMed
69.
Lord C, Rutter M, Le Couteur A: Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994, 24: 659-685. 10.1007/BF02172145.CrossRefPubMed
70.
Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, Pickles A, Rutter M: The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000, 30: 205-223. 10.1023/A:1005592401947.CrossRefPubMed
71.
Cox RW: AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996, 29: 162-173. 10.1006/cbmr.1996.0014.CrossRefPubMed
72.
Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM: Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004, 23 (Suppl 1): S208-S219.CrossRefPubMed
73.
Jenkinson M, Bannister P, Brady M, Smith S: Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002, 17: 825-841. 10.1006/nimg.2002.1132.CrossRefPubMed
74.
Jenkinson M, Smith S: A global optimisation method for robust affine registration of brain images. Med Image Anal. 2001, 5: 143-156. 10.1016/S1361-8415(01)00036-6.CrossRefPubMed
75.
Zhang Y, Brady M, Smith S: Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001, 20: 45-57. 10.1109/42.906424.CrossRefPubMed
76.
Nair A, Keown CL, Datko M, Shih P, Keehn B, Müller RA: Impact of methodological variables on functional connectivity findings in Autism Spectrum Disorders. Hum Brain Mapp. 2014, 35: 4035-4048. 10.1002/hbm.22456.CrossRefPubMed
77.
Van Dijk KR, Sabuncu MR, Buckner RL: The influence of head motion on intrinsic functional connectivity MRI. Neuroimage. 2012, 59: 431-438. 10.1016/j.neuroimage.2011.07.044.PubMedCentralCrossRefPubMed
78.
Satterthwaite TD, Elliott MA, Gerraty RT, Ruparel K, Loughead J, Calkins ME, Eickhoff SB, Hakonarson H, Gur RC, Gur RE: An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. Neuroimage. 2013, 64: 240-256.CrossRefPubMed
79.
Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE: Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012, 59: 2142-2154. 10.1016/j.neuroimage.2011.10.018.PubMedCentralCrossRefPubMed
80.
Saxe R, Wexler A: Making sense of another mind: the role of the right temporo-parietal junction. Neuropsychologia. 2005, 43: 1391-1399. 10.1016/j.neuropsychologia.2005.02.013.CrossRefPubMed
81.
Southgate V, Johnson MH, El Karoui I, Csibra G: Motor system activation reveals infants’ on-line prediction of others’ goals. Psychol Sci. 2010, 21: 355-359. 10.1177/0956797610362058.CrossRefPubMed
82.
Rizzolatti G, Fadiga L, Fogassi L, Gallese V: Resonance behaviors and mirror neurons. Arch Ital Biol. 1999, 137: 85-100.PubMed
83.
Rizzolatti G, Sinigaglia C: The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations. Nat Rev Neurosci. 2010, 11: 264-274. 10.1038/nrn2805.CrossRefPubMed
84.
Fogassi L, Ferrari PF, Gesierich B, Rozzi S, Chersi F, Rizzolatti G: Parietal lobe: from action organization to intention understanding. Science. 2005, 308: 662-667. 10.1126/science.1106138.CrossRefPubMed
85.
86.
87.
Caspers S, Zilles K, Laird AR, Eickhoff SB: ALE meta-analysis of action observation and imitation in the human brain. Neuroimage. 2010, 50: 1148-1167. 10.1016/j.neuroimage.2009.12.112.CrossRefPubMed
88.
Pobric G, Hamilton A: Action understanding requires the left inferior frontal gyrus. Curr Biol. 2006, 5: 524-529.CrossRef
89.
Kleinhans NM, Muller RA, Cohen DN, Courchesne E: Atypical functional lateralization of language in autism spectrum disorders. Brain Res. 2008, 1221: 115-125.PubMedCentralCrossRefPubMed
90.
Mitchell JP, Banaji MR, MacRae CN: The link between social cognition and self-referential thought in the medial prefrontal cortex. J Cogn Neurosci. 2005, 17: 1306-1315. 10.1162/0898929055002418.CrossRefPubMed
91.
Gusnard DA, Akbudak E, Shulman GL, Raichle ME: Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci. 2001, 98: 4259-4264. 10.1073/pnas.071043098.PubMedCentralCrossRefPubMed
92.
D’Argembeau A, Ruby P, Collette F, Degueldre C, Balteau E, Luxen A, Maquet P, Salmon E: Distinct regions of the medial prefrontal cortex are associated with self-referential processing and perspective taking. J Cogn Neurosci. 2007, 19: 935-944. 10.1162/jocn.2007.19.6.935.CrossRefPubMed
93.
Heatherton TF, Wyland CL, Macrae CN, Demos KE, Denny BT, Kelley WM: Medial prefrontal activity differentiates self from close others. Soc Cogn Affect Neurosci. 2006, 1: 18-25. 10.1093/scan/nsl001.PubMedCentralCrossRefPubMed
94.
Knoblich G, Flach R: Predicting the effects of actions: interactions of perception and action. Psychol Sci. 2001, 12: 467-472. 10.1111/1467-9280.00387.CrossRefPubMed
95.
Graf M, Reitzner B, Corves C, Casile A, Giese M, Prinz W: Predicting point-light actions in real-time. Neuroimage. 2007, 36: T22-T32.CrossRefPubMed
96.
Springer A, Brandstädter S, Liepelt R, Birngruber T, Giese M, Mechsner F, Prinz W: Motor execution affects action prediction. Brain Cogn. 2011, 76: 26-36. 10.1016/j.bandc.2011.03.007.CrossRefPubMed
97.
Marsh LE, Hamilton AFC: Dissociation of mirroring and mentalising systems in autism. Neuroimage. 2011, 56: 1511-1519. 10.1016/j.neuroimage.2011.02.003.CrossRefPubMed
98.
Cross ES, Mackie EC, Wolford G, Hamilton AFC: Contorted and ordinary body postures in the human brain. Exp Brain Res. 2010, 204: 397-407. 10.1007/s00221-009-2093-x.PubMedCentralCrossRefPubMed
99.
Downing PE, Peelen MV, Wiggett AJ, Tew BD: The role of the extrastriate body area in action perception. Soc Neurosci. 2006, 1: 52-62. 10.1080/17470910600668854.CrossRefPubMed
100.
Fishman I, Keown CL, Lincoln AJ, Pineda JA, Müller R-A: Atypical cross talk between mentalizing and mirror neuron networks in autism spectrum disorder. JAMA psychiatry. 2014, 71: 751-760. 10.1001/jamapsychiatry.2014.83.PubMedCentralCrossRefPubMed
Metadata
Title
The role of mirroring and mentalizing networks in mediating action intentions in autism
Authors
Lauren E Libero
Jose O Maximo
Hrishikesh D Deshpande
Laura G Klinger
Mark R Klinger
Rajesh K Kana
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Molecular Autism / Issue 1/2014
Electronic ISSN: 2040-2392
DOI
https://doi.org/10.1186/2040-2392-5-50

Other articles of this Issue 1/2014

Molecular Autism 1/2014 Go to the issue

Research

An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents

Short report

Transcriptomic changes in the frontal cortex associated with paternal age

Research

Protein signatures of oxidative stress response in a patient specific cell line model for autism

Research

Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome

Research

Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population

Short report

First evidence of sensory atypicality in mothers of children with Autism Spectrum Disorder (ASD)