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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2014

Open Access 01-12-2014 | Review

Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases

Authors: Xiaodan Wu, Luonan Chen, Xiangdong Wang

Published in: Clinical and Translational Medicine | Issue 1/2014

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Abstract

Identification and validation of interaction networks and network biomarkers have become more critical and important in the development of disease-specific biomarkers, which are functionally changed during disease development, progression or treatment. The present review headlined the definition, significance, research and potential application for network biomarkers, interaction networks and dynamical network biomarkers (DNB). Disease-specific interaction networks, network biomarkers, or DNB have great significance in the understanding of molecular pathogenesis, risk assessment, disease classification and monitoring, or evaluations of therapeutic responses and toxicities. Protein-based DNB will provide more information to define the differences between the normal and pre-disease stages, which might point to early diagnosis for patients. Clinical bioinformatics should be a key approach to the identification and validation of disease-specific biomarkers.
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Metadata
Title
Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases
Authors
Xiaodan Wu
Luonan Chen
Xiangdong Wang
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2014
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/2001-1326-3-16

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