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Open Access 01-12-2011 | Review

Drug therapy for hereditary cancers

Authors: Evgeny N Imyanitov, Vladimir M Moiseyenko

Published in: Hereditary Cancer in Clinical Practice | Issue 1/2011

Abstract

Tumors arising in patients with hereditary cancer syndromes may have distinct drug sensitivity as compared to their sporadic counterparts. Breast and ovarian neoplasms from BRCA1 or BRCA2 mutation carriers are characterized by deficient homologous recombination (HR) of DNA, that makes them particularly sensitive to platinum compounds or inhibitors of poly (ADP-ribose) polymerase (PARP). Outstandingly durable complete responses to high dose chemotherapy have been observed in several cases of BRCA-related metastatic breast cancer (BC). Multiple lines of evidence indicate that women with BRCA1-related BC may derive less benefit from taxane-based treatment than other categories of BC patients. There is virtually no reports directly assessing drug response in hereditary colorectal cancer (CRC) patients; studies involving non-selected (i.e., both sporadic and hereditary) CRC with high-level microsatellite instability (MSI-H) suggest therapeutic advantage of irinotecan. Celecoxib has been approved for the treatment of familial adenomatous polyposis (FAP). Hereditary medullary thyroid cancers (MTC) have been shown to be highly responsive to a multitargeted tyrosine kinase inhibitor vandetanib, which exerts specific activity towards mutated RET receptor. Given the rapidly improving accessibility of DNA analysis, it is foreseen that the potential predictive value of cancer-associated germ-line mutations will be increasingly considered in the future studies.

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Title: Drug therapy for hereditary cancers
Authors: Evgeny N Imyanitov
Vladimir M Moiseyenko
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Hereditary Cancer in Clinical Practice / Issue 1/2011
Electronic ISSN: 1897-4287
DOI: https://doi.org/10.1186/1897-4287-9-5

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Springer Medicine

Abstract

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Other articles of this Issue 1/2011

Primary appendiceal mucinous adenocarcinoma in two first-degree relatives: case report and review

Molecular study of the perforin gene in familial hematological malignancies

Case report: BRCA in the Ashkenazi population: are current testing guidelines too exclusive?

Factors Influencing Cancer Risk Perception in High Risk Populations: A Systematic Review

Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Greece

Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests

Keynote webinar | Spotlight on antibody–drug conjugates in cancer