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Open Access 01-12-2014 | Research

Colorectal cancer and self-reported tooth agenesis

Authors: Noralane M Lindor, Aung Ko Win, Steven Gallinger, Darshana Daftary, Stephen N Thibodeau, Renato Silva, Ariadne Letra

Published in: Hereditary Cancer in Clinical Practice | Issue 1/2014

Abstract

Background

Germline mutations in APC and AXIN2 are both associated with colon neoplasia as well as anomalous dental development. We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis.

Methods

Via a survey conducted on 1636 individuals with colorectal cancer (CRC) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry, self-reported information on congenitally missing teeth was collected. The frequency of missing teeth between cases and controls was compared using Pearson’s chi-squared test or Fisher’s exact test.

Results

4.8% of cases and 5.7% of controls reported having at least one missing tooth (p = 0.20). When we stratified by recruitment site, gender, and mutation status where available, frequency of missing teeth was not statistically significantly different between cases and controls.

Conclusions

This study did not provide support for there being a general predisposition to missing teeth among a large cohort of CRC patients. The study neither addresses nor excludes the possibility, however, that individuals presenting with notable hypodontia/oligodontia might still have an increased risk for colorectal neoplasia.

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Title: Colorectal cancer and self-reported tooth agenesis
Authors: Noralane M Lindor
Aung Ko Win
Steven Gallinger
Darshana Daftary
Stephen N Thibodeau
Renato Silva
Ariadne Letra
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Hereditary Cancer in Clinical Practice / Issue 1/2014
Electronic ISSN: 1897-4287
DOI: https://doi.org/10.1186/1897-4287-12-7

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