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Hereditary Cancer in Clinical Practice
Published in: Hereditary Cancer in Clinical Practice 1/2013

Open Access 01-12-2013 | Research

Sense of coherence and self-concept in Lynch syndrome

Authors: Helle Vendel Petersen, Steen Ladelund, Christina Carlsson, Mef Nilbert

Published in: Hereditary Cancer in Clinical Practice | Issue 1/2013

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Abstract

Objective

Most individuals who learn about hereditary cancer manage well, but identification of subgroups who find this knowledge burdening would allow psychosocial intervention. The objective of the study was to assess sense of coherence (SOC) in individuals with Lynch syndrome with comparison to a general population and correlation to self-concept.

Methods

A total of 345 individuals with Lynch syndrome completed the 13-item SOC scale and the 20-item Lynch syndrome self-concept scale. SOC scores were compared to a general Danish population and were correlated to self-concept estimates in individuals with Lynch syndrome. Characteristics of subgroups with adverse scores were described.

Results

Individuals with Lynch syndrome reported SOC scores similar to the general population. SOC and self-concept correlated well with a correlation coefficient of −0.51. Subsets with convergent and divergent scores, which may reflect different effects from knowledge about hereditary cancer, were identified.

Conclusion

Individuals with Lynch syndrome report SOC scores similar to the general population. SOC and self-concept correlate well but allow identification of subset who report adverse outcome and may be relevant for targeted intervention.
Appendix
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Literature
1.
Jarvinen HJ, Renkonen-Sinisalo L, Aktan-Collan K, Peltomaki P, Aaltonen LA, Mecklin JP: Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol 2009,27(28):4793–7. 10.1200/JCO.2009.23.7784CrossRefPubMed
2.
Lynch HT, Lynch JF, Lynch PM, Attard T: Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management. Fam Cancer 2008,7(1):27–39. 10.1007/s10689-007-9165-5CrossRefPubMed
3.
Lynch PM: Standards of care in diagnosis and testing for hereditary colon cancer. Fam Cancer 2008,7(1):65–72. 10.1007/s10689-007-9159-3CrossRefPubMed
4.
Vasen HF, Moslein G, Alonso A, Bernstein I, Bertario L, Blanco I, et al.: Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet 2007,44(6):353–62. 10.1136/jmg.2007.048991CrossRefPubMedPubMedCentral
5.
Vasen HF, Abdirahman M, Brohet R, Langers AM, Kleibeuker JH, Van KM, et al.: One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. Gastroenterology 2010,138(7):2300–6. 10.1053/j.gastro.2010.02.053CrossRefPubMed
6.
Andjelic-Dekic N, Tomasevic Z, Milosevic S, Kolarevic D, Jelic S: Do we know how many cancer patients have a family history of cancer? J BUON 2010,15(1):127–30.PubMed
7.
Aktan-Collan K, Haukkala A, Mecklin JP, Uutela A, Kaariainen H: Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study. Int J Cancer 2001,93(4):608–11. 10.1002/ijc.1372CrossRefPubMed
8.
Bjorvatn C, Eide GE, Hanestad BR, Havik OE: Anxiety and depression among subjects attending genetic counseling for hereditary cancer. Patient Educ Couns 2008,71(2):234–43. 10.1016/j.pec.2008.01.008CrossRefPubMed
9.
Bleiker EM, Menko FH, Kluijt I, Taal BG, Gerritsma MA, Wever LD, et al.: Colorectal cancer in the family: psychosocial distress and social issues in the years following genetic counselling. Hered Cancer Clin Pract 2007,5(2):59–66. 10.1186/1897-4287-5-2-59CrossRefPubMedPubMedCentral
10.
Meiser B: Psychological impact of genetic testing for cancer susceptibility: an update of the literature. Psychooncology 2005,14(12):1060–74. 10.1002/pon.933CrossRefPubMed
11.
Bleiker EM, Hahn DE, Aaronson NK: Psychosocial issues in cancer genetics–current status and future directions. Acta Oncol 2003,42(4):276–86. 10.1080/02841860310004391CrossRefPubMed
12.
Gritz ER, Peterson SK, Vernon SW, Marani SK, Baile WF, Watts BG, et al.: Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancer. J Clin Oncol 2005,23(9):1902–10. 10.1200/JCO.2005.07.102CrossRefPubMed
13.
Broadstock M, Michie S, Marteau T: Psychological consequences of predictive genetic testing: a systematic review. Eur J Hum Genet 2000,8(10):731–8. 10.1038/sj.ejhg.5200532CrossRefPubMed
14.
Nordin K, Liden A, Hansson M, Rosenquist R, Berglund G: Coping style, psychological distress, risk perception, and satisfaction in subjects attending genetic counselling for hereditary cancer. J Med Genet 2002,39(9):689–94. 10.1136/jmg.39.9.689CrossRefPubMedPubMedCentral
15.
Bartuma K, Nilbert M, Carlsson C: Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations. Hered Cancer Clin Pract 2012,10(1):6. 10.1186/1897-4287-10-6CrossRefPubMedPubMedCentral
16.
Watkins KE, Way CY, Fiander JJ, Meadus RJ, Esplen MJ, Green JS, et al.: Lynch syndrome: barriers to and facilitators of screening and disease management. Hered Cancer Clin Pract 2011, 9: 8. 10.1186/1897-4287-9-8CrossRefPubMedPubMedCentral
17.
Aktan-Collan K, Mecklin JP, Jarvinen H, Nystrom-Lahti M, Peltomaki P, Soderling I, et al.: Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer 2000,89(1):44–50. 10.1002/(SICI)1097-0215(20000120)89:1<44::AID-IJC8>3.0.CO;2-3CrossRefPubMed
18.
McAllister M: Personal theories of inheritance, coping strategies, risk perception and engagement in hereditary non-polyposis colon cancer families offered genetic testing. Clin Genet 2003,64(3):179–89. 10.1034/j.1399-0004.2003.00133.xCrossRefPubMed
19.
McCann S, Macauley D, Barnett Y, Bunting B, Bradley A, Jeffers L, et al.: Family communication, genetic testing and colonoscopy screening in hereditary non-polyposis colon cancer: a qualitative study. Psychooncology 2009.
20.
Palmquist AE, Koehly LM, Peterson SK, Shegog M, Vernon SW, Gritz ER: "The cancer bond": exploring the formation of cancer risk perception in families with Lynch syndrome. J Genet Couns 2010,19(5):473–86. 10.1007/s10897-010-9299-8CrossRefPubMedPubMedCentral
21.
Markus H, Wurf E: The dynamic self-concept: a social psychological perspective. In Annual rewiew of psychologi Edited by: Rosenweig MR. 1987, 299–337.
22.
Esplen MJ, Stuckless N, Berk T, Butler K, Gallinger S: The FAP self-concept scale (adult form). Fam Cancer 2009,8(1):39–50. 10.1007/s10689-008-9204-xCrossRefPubMed
23.
Esplen MJ, Stuckless N, Hunter J, Liede A, Metcalfe K, Glendon G, et al.: The BRCA Self-Concept Scale: a new instrument to measure self-concept in BRCA1/2 mutation carriers. Psychooncology 2009,18(11):1216–29. 10.1002/pon.1498CrossRefPubMed
24.
Esplen MJ, Stuckless N, Wong J, Gallinger S, Aronson M, Rothenmund H, et al.: Development and Validation of an Instrument to Measure the Impact of Genetic Testing on Self-Concept in Lynch Syndrome (LS). Clin Genet 2011,80(5):415–23. 10.1111/j.1399-0004.2011.01770.xCrossRefPubMedPubMedCentral
25.
Petersen HV, Domanska K, Bendahl PO, Wong J, Carlsson C, Bernstein I, et al.: Validation of a self-concept scale for lynch syndrome in different nationalities. J Genet Couns 2011,20(3):308–13. 10.1007/s10897-011-9349-xCrossRefPubMed
26.
Petersen HV, Esplen MJ, Ladelund S, Bernstein I, Sunde L, Carlsson C, et al.: Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study. Fam Cancer 2011,10(4):633–9. 10.1007/s10689-011-9459-5CrossRefPubMed
27.
Eriksson M, Lindstrom B: Antonovsky's sense of coherence scale and the relation with health: a systematic review. J Epidemiol Community Health 2006,60(5):376–81. 10.1136/jech.2005.041616CrossRefPubMedPubMedCentral
28.
Antonovsky A: Unravelling the mystery of health. How people manage stress and stay well. San Francisco: Jossey-Bass; 1987.
29.
Antonovsky A: The structure and properties of the sense of coherence scale. Soc Sci Med 1993,36(6):725–33. 10.1016/0277-9536(93)90033-ZCrossRefPubMed
30.
Eriksson M, Lindstrom B: Validity of Antonovsky's sense of coherence scale: a systematic review. J Epidemiol Community Health 2005,59(6):460–6. 10.1136/jech.2003.018085CrossRefPubMedPubMedCentral
31.
Siglen E, Bjorvatn C, Engebretsen LF, Berglund G, Natvig GK: The influence of cancer-related distress and sense of coherence on anxiety and depression in patients with hereditary cancer: a study of patients' sense of coherence 6 months after genetic counseling. J Genet Couns 2007,16(5):607–15. 10.1007/s10897-007-9095-2CrossRefPubMed
32.
Eriksson M, Lindstrom B: Antonovsky's sense of coherence scale and its relation with quality of life: a systematic review. J Epidemiol Community Health 2007,61(11):938–44. 10.1136/jech.2006.056028CrossRefPubMedPubMedCentral
33.
Idler EL, Benyamini Y: Self-rated health and mortality: a review of twenty-seven community studies. J Health Soc Behav 1997,38(1):21–37. 10.2307/2955359CrossRefPubMed
34.
Feldt T, Lintula H, Suominen S, Koskenvuo M, Vahtera J, Kivimaki M: Structural validity and temporal stability of the 13-item sense of coherence scale: prospective evidence from the population-based HeSSup study. Qual Life Res 2007,16(3):483–93. 10.1007/s11136-006-9130-zCrossRefPubMed
35.
Gilbar O: Do attitude toward cancer, sense of coherence and family high risk predict more psychological distress in women referred for a breast cancer examination? Women Health 2003,38(2):35–46. 10.1300/J013v38n02_03CrossRefPubMed
36.
Kenne SE, Browall M, Persson LO, Fall-Dickson J, Gaston-Johansson F: Relationship of sense of coherence to stressful events, coping strategies, health status, and quality of life in women with breast cancer. Psychooncology 2011, 22: 20--27.
37.
Stankunas M, Kalediene R, Starkuviene S: Sense of coherence and its associations with psychosocial health: results of survey of the unemployed in Kaunas. Medicina (Kaunas) 2009,45(10):807–13.
38.
Due EP, Holstein BE: "Sense of coherence", social class and health in a Danish population study]. Ugeskr Laeger 1998,160(51):7424–9.PubMed
39.
Gilbar O: Coping with threat. Implications for women with a family history of breast cancer. Psychosomatics 1998,39(4):329–39. 10.1016/S0033-3182(98)71321-0CrossRefPubMed
40.
Sundberg KK, Lampic C, Arvidson J, Wettergren L: Sense of coherence and need for support among long-term survivors of childhood cancer. Cancer Nurs 2011.
41.
42.
Nilsson KW, Leppert J, Simonsson B, Starrin B: Sense of coherence and psychological well-being: improvement with age. J Epidemiol Community Health 2010,64(4):347–52. 10.1136/jech.2008.081174CrossRefPubMed
Metadata
Title
Sense of coherence and self-concept in Lynch syndrome
Authors
Helle Vendel Petersen
Steen Ladelund
Christina Carlsson
Mef Nilbert
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Hereditary Cancer in Clinical Practice / Issue 1/2013
Electronic ISSN: 1897-4287
DOI
https://doi.org/10.1186/1897-4287-11-7

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