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Journal of Neurodevelopmental Disorders
Published in: Journal of Neurodevelopmental Disorders 1/2014

Open Access 01-12-2014 | Research

EEG hyper-connectivity in high-risk infants is associated with later autism

Authors: Elena V Orekhova, Mayada Elsabbagh, Emily JH Jones, Geraldine Dawson, Tony Charman, Mark H Johnson, The BASIS Team

Published in: Journal of Neurodevelopmental Disorders | Issue 1/2014

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Abstract

Background

It has been previously reported that structural and functional brain connectivity in individuals with autism spectrum disorders (ASD) is atypical and may vary with age. However, to date, no measures of functional connectivity measured within the first 2 years have specifically associated with a later ASD diagnosis.

Methods

In the present study, we analyzed functional brain connectivity in 14-month-old infants at high and low familial risk for ASD using electroencephalography (EEG). EEG was recorded while infants attended to videos. Connectivity was assessed using debiased weighted phase lag index (dbWPLI). At 36 months, the high-risk infants were assessed for symptoms of ASD.

Results

As a group, high-risk infants who were later diagnosed with ASD demonstrated elevated phase-lagged alpha-range connectivity as compared to both low-risk infants and high-risk infants who did not go on to ASD. Hyper-connectivity was most prominent over frontal and central areas. The degree of hyper-connectivity at 14 months strongly correlated with the severity of restricted and repetitive behaviors in participants with ASD at 3 years. These effects were not attributable to differences in behavior during the EEG session or to differences in spectral power.

Conclusions

The results suggest that early hyper-connectivity in the alpha frequency range is an important feature of the ASD neurophysiological phenotype.
Appendix
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Metadata
Title
EEG hyper-connectivity in high-risk infants is associated with later autism
Authors
Elena V Orekhova
Mayada Elsabbagh
Emily JH Jones
Geraldine Dawson
Tony Charman
Mark H Johnson
The BASIS Team
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Neurodevelopmental Disorders / Issue 1/2014
Print ISSN: 1866-1947
Electronic ISSN: 1866-1955
DOI
https://doi.org/10.1186/1866-1955-6-40

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