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Italian Journal of Pediatrics

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Open Access 01-12-2013 | Research

Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study

Authors: Giuseppe Puccio, Mario Giuffré, Maria Piccione, Ettore Piro, Grazia Rinaudo, Giovanni Corsello

Published in: Italian Journal of Pediatrics | Issue 1/2013

Abstract

Background

Intrauterine growth restriction (IUGR) and small for gestational age (SGA) birth have been considered possible indicators of the presence of malformations. The aim of this study is to evaluate such relationships in a population of newborns, along with other epidemiological and auxological parameters, in particular the ponderal index (PI).

Methods

We analyzed the birth data of 1093 infants, classified according to weight for gestational age as SGA, appropriate for gestational age (AGA) or large for gestational age (LGA). The prevalence of malformations was analyzed in relation to weight percentile at birth and SGA birth, maternal smoking, pregnancy diseases and PI.

Results

Our analysis showed no significant relationship between the prevalence of malformations and SGA birth. Maternal smoking and pregnancy diseases were strongly related to SGA birth, but not to a higher prevalence of malformations. PI, however, had a significant relationship with a higher prevalence of malformations, if analyzed as either a continuous variable or a categorical variable (cutoff: < 2.4).

Conclusions

The association between congenital malformations and birth weight for gestational age seems to be weak. As part of diagnostic screening for malformations in the neonatal period, PI could be considered a better predictor of risk than weight percentile.

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Title: Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study
Authors: Giuseppe Puccio
Mario Giuffré
Maria Piccione
Ettore Piro
Grazia Rinaudo
Giovanni Corsello
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2013
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/1824-7288-39-23

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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