Skip to main content
Top
Published in: Italian Journal of Pediatrics 1/2011

Open Access 01-12-2011 | Commentary

The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate?

Authors: Valerio Nobili, Claudia Della Corte, Lidia Monti, Anna Alisi, Ariel Feldstein

Published in: Italian Journal of Pediatrics | Issue 1/2011

Login to get access

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become over the last decade the most common form of chronic liver disease in children and adults. Thus, establishing the diagnosis of NAFLD is of utmost importance and represents a major challenge as the disease is generally silent and the current gold standard for diagnosis is an invasive liver biopsy, a procedure that is not suitable for screening purposes. Many non-invasive diagnostic tools have been evaluated so far. Recently the utility of ultrasonography for non-invasive diagnosis and estimation of hepatic steatosis has been demonstrated in a large prospective pediatric study.
Literature
1.
go back to reference Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P: The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009, 58: 1538-1544. 10.1136/gut.2008.171280.PubMedCentralCrossRefPubMed Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P: The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009, 58: 1538-1544. 10.1136/gut.2008.171280.PubMedCentralCrossRefPubMed
2.
go back to reference Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004, 40: 1387-1395. 10.1002/hep.20466.CrossRefPubMed Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004, 40: 1387-1395. 10.1002/hep.20466.CrossRefPubMed
3.
go back to reference Mazhar SM, Shiehmorteza M, Sirlin CB: Noninvasive assessment of hepatic steatosis. Clin Gastroenterol Hepatol. 2009, 7: 135-140. 10.1016/j.cgh.2008.11.023.CrossRefPubMed Mazhar SM, Shiehmorteza M, Sirlin CB: Noninvasive assessment of hepatic steatosis. Clin Gastroenterol Hepatol. 2009, 7: 135-140. 10.1016/j.cgh.2008.11.023.CrossRefPubMed
4.
go back to reference Chiloiro M, Riezzo G, Chiarappa S, Correale M, Guerra V, Amati L, Noviello MR, Jirillo E: Relationship among fatty liver, adipose tissue distribution and metabolic profile in moderately obese children: an ultrasonographic study. Curr Pharm Des. 2008, 14: 2693-2698. 10.2174/138161208786264197.CrossRefPubMed Chiloiro M, Riezzo G, Chiarappa S, Correale M, Guerra V, Amati L, Noviello MR, Jirillo E: Relationship among fatty liver, adipose tissue distribution and metabolic profile in moderately obese children: an ultrasonographic study. Curr Pharm Des. 2008, 14: 2693-2698. 10.2174/138161208786264197.CrossRefPubMed
5.
go back to reference Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ: Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol. 2009, 51: 1061-1067. 10.1016/j.jhep.2009.09.001.CrossRefPubMed Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ: Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol. 2009, 51: 1061-1067. 10.1016/j.jhep.2009.09.001.CrossRefPubMed
6.
go back to reference Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, Kato T, Takeda N, Okuda J, Ida K, Kawahito Y, Yoshikawa T, Okanoue T: The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007, 102: 2708-2715. 10.1111/j.1572-0241.2007.01526.x.CrossRefPubMed Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, Kato T, Takeda N, Okuda J, Ida K, Kawahito Y, Yoshikawa T, Okanoue T: The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007, 102: 2708-2715. 10.1111/j.1572-0241.2007.01526.x.CrossRefPubMed
7.
go back to reference Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, Mullen KD, Cooper JN, Sheridan MJ: The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002, 123: 745-750. 10.1053/gast.2002.35354.CrossRefPubMed Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, Mullen KD, Cooper JN, Sheridan MJ: The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002, 123: 745-750. 10.1053/gast.2002.35354.CrossRefPubMed
8.
go back to reference Soder RB, Baldisserotto M, Duval da Silva V: Computer-Assisted Ultrasound Analysis of Liver Echogenicity in Obese and Normal-Weight Children. AJR. 2009, 192: W201-W205. 10.2214/AJR.08.2061.CrossRefPubMed Soder RB, Baldisserotto M, Duval da Silva V: Computer-Assisted Ultrasound Analysis of Liver Echogenicity in Obese and Normal-Weight Children. AJR. 2009, 192: W201-W205. 10.2214/AJR.08.2061.CrossRefPubMed
9.
go back to reference Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, Feldstein AE, Nobili V: Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD. JPGN. 2011, 53: 190-5.PubMedCentralPubMed Shannon A, Alkhouri N, Carter-Kent C, Monti L, Devito R, Lopez R, Feldstein AE, Nobili V: Ultrasonographic Quantitative Estimation of Hepatic Steatosis in Children With NAFLD. JPGN. 2011, 53: 190-5.PubMedCentralPubMed
10.
go back to reference Springer F, Machann J, Claussen CD, Schick F, Schwenzer NF: Liver fat content determined by magnetic resonance imaging and spectroscopy. World J Gastroenterol. 2010, 16: 1560-6. 10.3748/wjg.v16.i13.1560.PubMedCentralCrossRefPubMed Springer F, Machann J, Claussen CD, Schick F, Schwenzer NF: Liver fat content determined by magnetic resonance imaging and spectroscopy. World J Gastroenterol. 2010, 16: 1560-6. 10.3748/wjg.v16.i13.1560.PubMedCentralCrossRefPubMed
11.
go back to reference Pozzato C, Radaelli G, Dall'Asta C, Verduci E, Villa A, Villa C, Scaglioni S, Riva E, Pontiroli AE, Cornalba G, Giovannini M: MRI in Identifying Hepatic Steatosis in Obese Children and Relation to Ultrasonography and Metabolic Findings. JPGN. 2008, 47: 493-9.PubMed Pozzato C, Radaelli G, Dall'Asta C, Verduci E, Villa A, Villa C, Scaglioni S, Riva E, Pontiroli AE, Cornalba G, Giovannini M: MRI in Identifying Hepatic Steatosis in Obese Children and Relation to Ultrasonography and Metabolic Findings. JPGN. 2008, 47: 493-9.PubMed
12.
go back to reference Nobili V, Bedogni G, Alisi A, Pietrobattista A, Risé P, Galli C, Agostoni C: Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child. 2011, 96: 350-3. 10.1136/adc.2010.192401.CrossRefPubMed Nobili V, Bedogni G, Alisi A, Pietrobattista A, Risé P, Galli C, Agostoni C: Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child. 2011, 96: 350-3. 10.1136/adc.2010.192401.CrossRefPubMed
Metadata
Title
The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate?
Authors
Valerio Nobili
Claudia Della Corte
Lidia Monti
Anna Alisi
Ariel Feldstein
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2011
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/1824-7288-37-36

Other articles of this Issue 1/2011

Italian Journal of Pediatrics 1/2011 Go to the issue