Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2011

Open Access 01-12-2011 | Research

Renal tubular dysfunction measured by N-acetyl-beta glucosaminidase/Creatinine activity index in children receiving antiepileptic drugs: a randomized controlled trial

Authors: Mojgan Mazaheri, Afshin Samaie, Vahid Semnani

Published in: Italian Journal of Pediatrics | Issue 1/2011

Login to get access

Abstract

To evaluate renal side-effects of anti-epileptic medication by valproate (VPA) and carbamazepine (CBZ), we performed a prospective study to assess renal tubular function by measuring N-acetyl-β glucosaminidase (NAG)/Cr activity index in epileptic children. The study was conducted on 112 children who were diagnosed with epilepsy (28 patients were observed before treatment with anti-epileptics, 28 children were administered VPA, 28 children were treated with CBZ, and 28 healthy children were selected age &sex matched for). An especial NAG assay kit was used for quantitative measuring of NAG in patient urine samples. The patients receiving VPA exhibited higher rate of NAG activity compared with the two groups which not receiving anti-epileptic drugs. Measurement of urinary NAG/Cr index in the children who received CBZ also, was significantly higher than those who were not administered anti-epileptic drugs. The measurement of NAG/Cr index in the VPA group was significantly higher than that in the CBZ group (NAG index: 2.75 versus 1.71). Children on anti-epileptic treatment with VPA or CBZ might demonstrate signs of renal tubular dysfunction, reflected by NAG/Cr activity index. This side effect can be potentially more occurred following VPA administration.
Appendix
Available only for authorised users
Literature
1.
Yüksel A, Cengiz M, Seven M, Cengiz S: N-Acetyl-b-Glucosaminidase and b-Galactosidase Activity in Children Receiving Antiepileptic Drugs. Pediatr Neurol. 2003, 20: 24-26.CrossRef
2.
Camfield C, Camfield P, Smith E, Tibbles JAR: Asymptomatic children with epilepsy: Little benefit from screening for anticonvulsant induced liver, blood, or renal damage. Neurology. 1986, 36: 838-841.CrossRefPubMed
3.
Oba K, Hirai M, Ajiro Y, Okazaki K, Sato S, Sasai K, Suzuki T, Nakano H, Metori S: Effect of age on urinary excretion of N-acetyl-beta-D-glucosaminidase. Nippon Ika Daigaku Zasshi. 1999, 66: 33-36. 10.1272/jnms.66.33. 1999CrossRefPubMed
4.
Price RG, Dance N, Richards B, Cattell WR: The excretion of N-acetyl-beta-glucosaminidase and beta-galactosidase following surgery to the kidney. Clin Chim Acta. 1970, 27: 65-72. 10.1016/0009-8981(70)90375-X.CrossRefPubMed
5.
Unay B, Akin R, Sarici SU, Gok F, Kurt I, Gokcay E: Evaluation of renal tubular function in children taking anti-epileptic treatment. Nephrology (Carlton). 2006, 11: 485-488. 10.1111/j.1440-1797.2006.00699.x.CrossRef
6.
Skálová S: The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. Acta Medica (Hradec Kralove). 2005, 48: 75-80.
7.
Hurkacz M, Wiela-Hojeńska A, Orzechowska-Juzwenko K, Kozik A, Unolt J: Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine. Pol Merkur Lekarski. 2001, 11: 480-483.PubMed
8.
Korinthenberg R, Säger J, Zimmerhackl LB: Increased urinary excretion of tubular enzymes and proteins in children with epilepsy. Eur J Paediatr Neurol. 2000, 4: 263-267. 10.1053/ejpn.2000.0378.CrossRefPubMed
9.
Otsuka T, Sunaga Y, Hikima A: Urinary N-acetyl-beta-glucosaminidase and guanidinoacetic acid levels in epileptic patients treated with anti-epileptic drugs. Brain Dev. 1994, 16: 437-440. 10.1016/0387-7604(94)90003-5.CrossRefPubMed
10.
Tseng CL, Wang PJ, Tsau YK, Lin MY, Shen YZ: Urinary N-acetyl-beta-glucosaminidase (NAG) in children receiving antiepileptic drugs. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992, 33: 251-256. 1992PubMed
11.
Huland H, Gonnermann D, Werner B, Possin U: A new test to predict reversibility of hydronephrotic atrophy after stable partial unilateral ureteral obstruction. J Urol. 1988, 140: 1591-1594.PubMed
12.
Everaert K, Van de Wiele C, Delanghe J, Vander Eecken H, Van Haelst JP, Van de Voorde J: Urinary excretion of tubular proteins and the technetium-99m dimercaptosuccinic acid (DMSA) absolute renal uptake in partial ureteral obstruction in rats: a functional evaluation of hydronephrotic kidneys. Urol Res. 1999, 7: 127-133.CrossRef
13.
Korinthenberg R, Wehrle L, Zimmerhackl LB: Renal tubular dysfunction following treatment with anti-epileptic drugs. Eur J Pediatr. 1994, 153: 855-858. 10.1007/BF01972897.CrossRefPubMed
14.
15.
Novo MLP, Izumi T, Yokota K, Fukuyama Y: Urinary excretion of N-acetyl b-glucosaminidase and b-galactosidase by patients with epilepsy. Brain Dev. 1993, 15: 157-160. 10.1016/0387-7604(93)90055-D.CrossRef
16.
Watanabe K, Kojima T, Fukuda J: Reliability of urinary N-acetyl-b-D glucosaminidase as an indicator of renal tubular damage in neonates. Biol Neonate. 1987, 52: 16-21. 10.1159/000242679.CrossRefPubMed
17.
Wellwood JM, Ellis BG, Price RG, Hammond K, Thompson AE, Jones NF: Urinary N-acetyl-b-D glucosaminidase activities in patients with renal disease. BMJ. 1975, 3: 408-411. 10.1136/bmj.3.5980.408.PubMedCentralCrossRefPubMed
18.
Unay B, Akin R, Sarici SU, Gok F, Kurt I, Gokcay E: Evaluation of renal tubular function in children taking anti-epileptic treatment. Nephrology (Carlton). 2006, 11: 485-488. 10.1111/j.1440-1797.2006.00699.x.CrossRef
19.
Verrotti A, Greco R, Pascarella R, Matera V, Morgese G, Chiarelli F: Renal tubular function in patients receiving anticonvulsant therapy: a long-term study. Epilepsia. 2000, 41: 1432-1435. 10.1111/j.1528-1157.2000.tb00118.x.CrossRefPubMed
Metadata
Title
Renal tubular dysfunction measured by N-acetyl-beta glucosaminidase/Creatinine activity index in children receiving antiepileptic drugs: a randomized controlled trial
Authors
Mojgan Mazaheri
Afshin Samaie
Vahid Semnani
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2011
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/1824-7288-37-21

Other articles of this Issue 1/2011

Italian Journal of Pediatrics 1/2011 Go to the issue

Research

The temperament of preterm infant in preschool age

Review

"Electro-clinical syndromes" with onset in paediatric age: the highlights of the clinical-EEG, genetic and therapeutic advances

Research

Immune-related disorders in families of children with inflammatory bowel disease - A prospective cohort study

Research

Prevalence and clinical pattern of paediatric HIV infection at the University College Hospital, Ibadan, Nigeria: a prospective cross-sectional study

Research

Foreign children with cancer in Italy

Research

Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India