Skip to main content
Top
Published in: Head & Neck Oncology 1/2010

Open Access 01-12-2010 | Research

Oral squamous cell carcinoma in non-smoking and non-drinking patients

Authors: Astrid L Kruse, Marius Bredell, Klaus W Grätz

Published in: Head & Neck Oncology | Issue 1/2010

Login to get access

Abstract

Introduction

Of the many different factors associated with an increased risk for oral squamous cell carcinoma (SCC), tobacco and alcohol seem to be the most studied. The aim of the current study was to evaluate the clinicopathologic characteristics of patients without the mentioned risk factors.

Patients and Methods

Out of 278 patients (159 male and 119 female patients) with oral SCC, 67 patients had no history of tobacco or alcohol use. The minimum follow-up time was 12 months.

Results

Of the 67 patients, 45 (67.2%) were women, and the mean age was 70 years. The most common tumor sites were mandibular alveolar ridge (22) and maxilla (18). Fifteen patients experienced a recurrence, and 10 developed lymph node metastases during the follow-up period.

Conclusion

The group of patients with no tobacco and alcohol use tends toward a higher proportion of females, a higher proportion of patients over 70 years, and a higher number of oral maxillary SCC.
Appendix
Available only for authorised users
Literature
1.
go back to reference Jaber MA: Oral epithelial dysplasia in non-users of tobacco and alcohol: an analysis of clinicopathologic characteristics and treatment outcome. J Oral Sci. 2010, 52 (1): 13-21. 10.2334/josnusd.52.13.CrossRefPubMed Jaber MA: Oral epithelial dysplasia in non-users of tobacco and alcohol: an analysis of clinicopathologic characteristics and treatment outcome. J Oral Sci. 2010, 52 (1): 13-21. 10.2334/josnusd.52.13.CrossRefPubMed
2.
go back to reference Ng SK, Kabat GC, Wynder EL: Oral cavity cancer in non-users of tobacco. J Natl Cancer Inst. 1993, 85 (9): 743-5. 10.1093/jnci/85.9.743.CrossRefPubMed Ng SK, Kabat GC, Wynder EL: Oral cavity cancer in non-users of tobacco. J Natl Cancer Inst. 1993, 85 (9): 743-5. 10.1093/jnci/85.9.743.CrossRefPubMed
3.
go back to reference Talamini R, La Vecchia C, Levi F, Conti E, Favero A, Franceschi S: Cancer of the oral cavity and pharynx in nonsmokers who drink alcohol and in nondrinkers who smoke tobacco. J Natl Cancer Inst. 1998, 90 (24): 1901-3. 10.1093/jnci/90.24.1901.CrossRefPubMed Talamini R, La Vecchia C, Levi F, Conti E, Favero A, Franceschi S: Cancer of the oral cavity and pharynx in nonsmokers who drink alcohol and in nondrinkers who smoke tobacco. J Natl Cancer Inst. 1998, 90 (24): 1901-3. 10.1093/jnci/90.24.1901.CrossRefPubMed
4.
go back to reference Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang ZF, Berthiller J, Boffetta P: Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007, 99 (10): 777-89. 10.1093/jnci/djk179.CrossRefPubMed Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang ZF, Berthiller J, Boffetta P: Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007, 99 (10): 777-89. 10.1093/jnci/djk179.CrossRefPubMed
5.
go back to reference Boffetta P, Mashberg A, Winkelmann R, Garfinkel L: Carcinogenic effect of tobacco smoking and alcohol drinking on anatomic sites of the oral cavity and oropharynx. nt J Cancer. 1992, 52 (4): 530-3. 10.1002/ijc.2910520405. Boffetta P, Mashberg A, Winkelmann R, Garfinkel L: Carcinogenic effect of tobacco smoking and alcohol drinking on anatomic sites of the oral cavity and oropharynx. nt J Cancer. 1992, 52 (4): 530-3. 10.1002/ijc.2910520405.
6.
go back to reference Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF: Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988, 48 (11): 3282-7.PubMed Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF: Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988, 48 (11): 3282-7.PubMed
7.
go back to reference Sanderson RJ, de Boer MF, Damhuis RA, Meeuwis CA, Knegt PP: The influence of alcohol and smoking on the incidence of oral and oropharyngeal cancer in women. Clin Otolaryngol Allied Sci. 1997, 22 (5): 444-8. 10.1046/j.1365-2273.1997.00049.x.CrossRefPubMed Sanderson RJ, de Boer MF, Damhuis RA, Meeuwis CA, Knegt PP: The influence of alcohol and smoking on the incidence of oral and oropharyngeal cancer in women. Clin Otolaryngol Allied Sci. 1997, 22 (5): 444-8. 10.1046/j.1365-2273.1997.00049.x.CrossRefPubMed
8.
go back to reference Harris SL, Kimple RJ, Hayes DN, Couch ME, Rosenman JG: Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers. Head Neck. 2010, 32 (4): 499-503.PubMed Harris SL, Kimple RJ, Hayes DN, Couch ME, Rosenman JG: Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers. Head Neck. 2010, 32 (4): 499-503.PubMed
9.
go back to reference Dahlstrom KR, Little JA, Zafereo ME, Lung M, Wei Q, Sturgis EM: Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. Head Neck. 2008, 30 (1): 75-84. 10.1002/hed.20664.CrossRefPubMed Dahlstrom KR, Little JA, Zafereo ME, Lung M, Wei Q, Sturgis EM: Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. Head Neck. 2008, 30 (1): 75-84. 10.1002/hed.20664.CrossRefPubMed
10.
go back to reference Wiseman SM, Swede H, Stoler DL, Anderson GR, Rigual NR, Hicks WL, Douglas WG, Tan D, Loree TR: Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: an analysis of clinicopathologic characteristics and treatment outcomes. Ann Surg Oncol. 2003, 10 (5): 551-7. 10.1245/ASO.2003.09.010.CrossRefPubMed Wiseman SM, Swede H, Stoler DL, Anderson GR, Rigual NR, Hicks WL, Douglas WG, Tan D, Loree TR: Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: an analysis of clinicopathologic characteristics and treatment outcomes. Ann Surg Oncol. 2003, 10 (5): 551-7. 10.1245/ASO.2003.09.010.CrossRefPubMed
11.
go back to reference Schmidt BL, Dierks EJ, Homer L, Potter B: Tobacco smoking history and presentation of oral squamous cell carcinoma. J Oral Maxillofac Surg. 2004, 62 (9): 1055-8. 10.1016/j.joms.2004.03.010.CrossRefPubMed Schmidt BL, Dierks EJ, Homer L, Potter B: Tobacco smoking history and presentation of oral squamous cell carcinoma. J Oral Maxillofac Surg. 2004, 62 (9): 1055-8. 10.1016/j.joms.2004.03.010.CrossRefPubMed
12.
go back to reference Keller AZ, Terris M: The association of alcohol and tobacco with cancer of the mouth and pharynx. Am J Public Health Nations Health. 1965, 55 (10): 1578-85.PubMedCentralCrossRefPubMed Keller AZ, Terris M: The association of alcohol and tobacco with cancer of the mouth and pharynx. Am J Public Health Nations Health. 1965, 55 (10): 1578-85.PubMedCentralCrossRefPubMed
13.
go back to reference Kruse AL, Grätz KW: Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years. Head Neck Oncol. 2009, 1 (1): 28-10.1186/1758-3284-1-28.PubMedCentralCrossRefPubMed Kruse AL, Grätz KW: Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years. Head Neck Oncol. 2009, 1 (1): 28-10.1186/1758-3284-1-28.PubMedCentralCrossRefPubMed
14.
go back to reference Kreimer AR, Clifford GM, Boyle P, Franceschi S: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005, 14 (2): 467-75. 10.1158/1055-9965.EPI-04-0551.CrossRefPubMed Kreimer AR, Clifford GM, Boyle P, Franceschi S: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005, 14 (2): 467-75. 10.1158/1055-9965.EPI-04-0551.CrossRefPubMed
15.
go back to reference Matzow T, Boysen M, Kalantari M, Johansson B, Hagmar B: Low detection rate of HPV in oral and laryngeal carcinomas. Acta Oncol. 1998, 37 (1): 73-6. 10.1080/028418698423203.CrossRefPubMed Matzow T, Boysen M, Kalantari M, Johansson B, Hagmar B: Low detection rate of HPV in oral and laryngeal carcinomas. Acta Oncol. 1998, 37 (1): 73-6. 10.1080/028418698423203.CrossRefPubMed
16.
go back to reference Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, Danassi-Afentaki D, Foukas P, Kyroudi A, Laskaris G, Herrington CS, Kittas C: "High risk" HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Mod Pathol. 2000, 13 (6): 644-53. 10.1038/modpathol.3880113.CrossRefPubMed Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, Danassi-Afentaki D, Foukas P, Kyroudi A, Laskaris G, Herrington CS, Kittas C: "High risk" HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Mod Pathol. 2000, 13 (6): 644-53. 10.1038/modpathol.3880113.CrossRefPubMed
17.
go back to reference Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, Hsu AA, Eng P, Koong HN, Thirugnanam A, Tan EH: Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol. 2006, 24 (15): 2245-51. 10.1200/JCO.2005.04.8033.CrossRefPubMed Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, Hsu AA, Eng P, Koong HN, Thirugnanam A, Tan EH: Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol. 2006, 24 (15): 2245-51. 10.1200/JCO.2005.04.8033.CrossRefPubMed
18.
go back to reference Gealy R, Zhang L, Siegfried JM, Luketich JD, Keohavong P: Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women. Cancer Epidemiol Biomarkers Prev. 1999, 8 (4 Pt 1): 297-302.PubMed Gealy R, Zhang L, Siegfried JM, Luketich JD, Keohavong P: Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women. Cancer Epidemiol Biomarkers Prev. 1999, 8 (4 Pt 1): 297-302.PubMed
19.
go back to reference Cheng YW, Chiou HL, Sheu GT, Hsieh LL, Chen JT, Chen CY, Su JM, Lee H: The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res. 2001, 61 (7): 2799-803.PubMed Cheng YW, Chiou HL, Sheu GT, Hsieh LL, Chen JT, Chen CY, Su JM, Lee H: The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res. 2001, 61 (7): 2799-803.PubMed
Metadata
Title
Oral squamous cell carcinoma in non-smoking and non-drinking patients
Authors
Astrid L Kruse
Marius Bredell
Klaus W Grätz
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2010
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-2-24

Other articles of this Issue 1/2010

Head & Neck Oncology 1/2010 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine