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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2014

Open Access 01-12-2014 | Poster presentation

The role of inflammation in secondary cardiac dysfunction following trauma

Authors: Nick M Wilson, Henry D De’Ath, Joanna Manson

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Special Issue 1/2014

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Excerpt

Recent evidence supports the existence of a trauma induced secondary cardiac injury (TISCI) that is associated with poor clinical outcome [1]. Cardiac dysfunction has been demonstrated as early as 30mins after injury and is characterised by reduced contractility that is unresponsive to increased perfusion and preload [2].Inflammation is implicated as a key aetiological factor [1, 3]. This review aims to evaluate current knowledge on cardiac inflammation after trauma and highlight mechanisms for future study. …
Literature
1.
De'Ath HD, Manson J, Davenport R, Glasgow S, Renfrew I, Davies LC: Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines. Shock. 2013, 39 (5): 415-20. 10.1097/SHK.0b013e31828ded41.CrossRefPubMed
2.
Shahani R, Klein LV, Marshall JG, Nicholson S, Rubin BB, Walker PM: Hemorrhage-induced alpha-adrenergic signaling results in myocardial TNF-alpha expression and contractile dysfunction. Am J Physiol Heart Circ Physiol. 2001, 281 (1): H84-92.PubMed
3.
Kher A, Wang M, Tsai BM, Pitcher JM, Greenbaum ES, Nagy RD: Sex differences in the myocardial inflammatory response to acute injury. Shock. 2005, 23 (1): 1-10. 10.1097/01.shk.0000148055.12387.15.CrossRefPubMed
Metadata
Title
The role of inflammation in secondary cardiac dysfunction following trauma
Authors
Nick M Wilson
Henry D De’Ath
Joanna Manson
Publication date
01-12-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1757-7241-22-S1-P12

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