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Open Access 01-12-2013 | Brief communication

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Authors: Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic, Australian Ovarian Cancer Study Group

Published in: Journal of Ovarian Research | Issue 1/2013

Abstract

Background

High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfunctional BRCA/Fanconi anaemia (BRCA/FA) pathway, which is critical to the homologous recombination DNA repair machinery. An impaired BRCA/FA pathway sensitises tumours to the treatment with DNA cross-linking agents and to PARP inhibitors. The vast majority of inactivating mutations in the BRCA/FA pathway are in the BRCA1 and BRCA2 genes and occur predominantly in high-grade serous cancer. Another member of the BRCA/FA pathway, PALB2 (FANCN), was reported to have been inactivated by DNA methylation in some sporadic ovarian cancers. We therefore sought to investigate the role of PALB2 methylation in high-grade serous ovarian cancers.

Finding

PALB2 methylation was investigated in 92 high-grade serous ovarian cancer samples using methylation-sensitive high-resolution melting analysis. DNA methylation of PALB2 was not detected in any of the ovarian cancer samples investigated.

Conclusion

Epigenetic silencing by DNA methylation of PALB2 is not a common event in high-grade serous ovarian cancers.

Available only for authorised users

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Title: No evidence for PALB2 methylation in high-grade serous ovarian cancer
Authors: Thomas Mikeska
Kathryn Alsop
Gillian Mitchell
David DL Bowtell
Alexander Dobrovic
Australian Ovarian Cancer Study Group
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2013
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/1757-2215-6-26

At a glance: The STEP trials

Springer Medicine

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Abstract

Background

Finding

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Finding

Conclusion

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