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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2012

Open Access 01-12-2012 | Review

MicroRNAs and ovarian function

Authors: Jason Baley, Julang Li

Published in: Journal of Ovarian Research | Issue 1/2012

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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.
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Metadata
Title
MicroRNAs and ovarian function
Authors
Jason Baley
Julang Li
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2012
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/1757-2215-5-8

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