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Open Access 01-12-2012 | Review

Involvement of autophagy in ovarian cancer: a working hypothesis

Authors: Claudia Peracchio, Oscar Alabiso, Guido Valente, Ciro Isidoro

Published in: Journal of Ovarian Research | Issue 1/2012

Abstract

Autophagy is a lysosomal-driven catabolic process that contributes to preserve cell and tissue homeostases through the regular elimination of damaged, aged and redundant self-constituents. In normal cells, autophagy protects from DNA mutation and carcinogenesis by preventive elimination of pro-oxidative mitochondria and protein aggregates. Mutations in oncogenes and oncosuppressor genes dysregulate autophagy. Up-regulated autophagy may confer chemo- and radio-resistance to cancer cells, and also a pro-survival advantage in cancer cells experiencing oxygen and nutrient shortage. This fact is the rationale for using autophagy inhibitors along with anti-neoplastic therapies. Yet, aberrant hyper-induction of autophagy can lead to cell death, and this phenomenon could also be exploited for cancer therapy. The actual level of autophagy in the cancer cell is greatly affected by vascularization, inflammation, and stromal cell infiltration. In addition, small non-coding microRNAs have recently emerged as important epigenetic modulators of autophagy. The present review focuses on the potential involvement of macroautophagy, and on its genetic and epigenetic regulation, in ovarian cancer pathogenesis and progression.

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Title: Involvement of autophagy in ovarian cancer: a working hypothesis
Authors: Claudia Peracchio
Oscar Alabiso
Guido Valente
Ciro Isidoro
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2012
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/1757-2215-5-22

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Involvement of autophagy in ovarian cancer: a working hypothesis

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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