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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2011

Open Access 01-12-2011 | Research

Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients

Authors: Anna Felisiak-Golabek, Alina Rembiszewska, Iwona K Rzepecka, Lukasz Szafron, Radoslaw Madry, Magdalena Murawska, Tomasz Napiorkowski, Piotr Sobiczewski, Beata Osuch, Jolanta Kupryjanczyk, the Polish Ovarian Cancer Study Group (POCSG)

Published in: Journal of Ovarian Research | Issue 1/2011

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Abstract

Background

Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status.

Methods

Survivin and TP53 expression was evaluated immunohistochemically in 435 archival samples of ovarian carcinomas (244 patients were treated with platinum/cyclophosphamide-PC/PAC; 191-with taxane-platinum (TP) agents). Univariate and multivariate statistical analyses were performed in patients groups divided according to the administered chemotherapeutic regimen, and in subgroups with and without TP53 accumulation (TP53+ and TP53-, respectively).

Results

Nuclear and cytoplasmic survivin expression was observed in 92% and 74% of the carcinomas, respectively. In patients treated with TP, high nuclear survivin expression decreased the risk of disease recurrence and death, and increased the probability of high platinum sensitivity (p < 0.01), but only in the TP53(+) group, and not in the TP53(-) group.

Conclusions

It appears that TP53 status determines the clinical importance of nuclear survivin expression in taxane-platinum treated ovarian cancer patients.
Appendix
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Metadata
Title
Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients
Authors
Anna Felisiak-Golabek
Alina Rembiszewska
Iwona K Rzepecka
Lukasz Szafron
Radoslaw Madry
Magdalena Murawska
Tomasz Napiorkowski
Piotr Sobiczewski
Beata Osuch
Jolanta Kupryjanczyk
the Polish Ovarian Cancer Study Group (POCSG)
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2011
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/1757-2215-4-20

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