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Open Access 01-12-2013 | Letter to the Editor

STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia

Authors: Zhi-Yuan Qiu, Lei Fan, Li Wang, Chun Qiao, Yu-Jie Wu, Jian-Feng Zhou, Wei Xu, Jian-Yong Li

Published in: Journal of Hematology & Oncology | Issue 1/2013

Abstract

T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder and can cooccur in the context of pure red cell aplasia (PRCA). The aim of the current study was to analyze the signal transducer and activator of transcription 3 (STAT3) mutation status and its clinical significance in T-LGLL. We found STAT3 mutations in 21.4% of patients with T-LGLL. High β2-MG (β2-microglobulin) levels (P = 0.005), neutropenia (P = 0.018) and PRCA (P = 0.001) all displayed a significant association with STAT3 mutations. In univariate analysis, treatment-free survival (TFS) was affected by STAT3 mutation status (P = 0.008) and β2-MG (P = 0.006). Our results demonstrate the remarkable correlation of STAT3 mutation with PRCA, neutropenia and β2-MG.

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Title: STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia
Authors: Zhi-Yuan Qiu
Lei Fan
Li Wang
Chun Qiao
Yu-Jie Wu
Jian-Feng Zhou
Wei Xu
Jian-Yong Li
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2013
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/1756-8722-6-82

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