Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2013

Open Access 01-12-2013 | Research

Validation of the M. D. Anderson Symptom Inventory multiple myeloma module

Authors: Desiree Jones, Elisabeth G Vichaya, Xin Shelley Wang, Loretta A Williams, Nina D Shah, Sheeba K Thomas, Valen E Johnson, Richard E Champlin, Charles S Cleeland, Tito R Mendoza

Published in: Journal of Hematology & Oncology | Issue 1/2013

Login to get access

Abstract

Background

The symptom burden associated with multiple myeloma (MM) is often severe. Presently, no instrument comprehensively assesses disease-related and treatment-related symptoms in patients with MM. We sought to validate a module of the M. D. Anderson Symptom Inventory (MDASI) developed specifically for patients with MM (MDASI-MM).

Methods

The MDASI-MM was developed with clinician input, cognitive debriefing, and literature review, and administered to 132 patients undergoing induction chemotherapy or stem cell transplantation. We demonstrated the MDASI-MM’s reliability (Cronbach α values); criterion validity (item and subscale correlations between the MDASI-MM and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the EORTC MM module (QLQ-MY20)), and construct validity (differences between groups by performance status). Ratings from transplant patients were examined to demonstrate the MDASI-MM’s sensitivity in detecting the acute worsening of symptoms post-transplantation.

Results

The MDASI-MM demonstrated excellent correlations with subscales of the 2 EORTC instruments, strong ability to distinguish clinically different patient groups, high sensitivity in detecting change in patients’ performance status, and high reliability. Cognitive debriefing confirmed that the MDASI-MM encompasses the breadth of symptoms relevant to patients with MM.

Conclusion

The MDASI-MM is a valid, reliable, comprehensive-yet-concise tool that is recommended as a uniform symptom assessment instrument for patients with MM.
Appendix
Available only for authorised users
Literature
1.
Brenner H, Gondos A, Pulte D: Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood. 2008, 111: 2521-2526. 10.1182/blood-2007-08-104984.CrossRefPubMed
2.
Catley L, Anderson K: Strategies to improve the outcome of stem cell transplantation in multiple myeloma. The hematology journal: the official journal of the European Haematology Association/EHA. 2004, 5: 9-23.CrossRef
3.
Chapko MK, Syrjala KL, Schilter L, Cummings C, Sullivan KM: Chemoradiotherapy toxicity during bone marrow transplantation: time course and variation in pain and nausea. Bone Marrow Transplant. 1989, 4: 181-186.PubMed
4.
Leger CS, Bredeson C, Kearns B, Bence-Bruckler I, Atkins H, Huebsch L: Autologous blood and marrow transplantation in patients 60 years and older. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation. 2000, 6: 204-210. 10.1016/S1083-8791(00)70044-9.CrossRef
5.
Sherman AC, Simonton S, Latif U, Spohn R, Tricot G: Psychosocial adjustment and quality of life among multiple myeloma patients undergoing evaluation for autologous stem cell transplantation. Bone Marrow Transplant. 2004, 33: 955-962. 10.1038/sj.bmt.1704465.CrossRefPubMed
6.
Wisloff F, Eika S, Hippe E, Hjorth M, Holmberg E, Kaasa S, Palva I, Westin J: Measurement of health-related quality of life in multiple myeloma. Nordic myeloma study group. British journal of haematology. 1996, 92: 604-613. 10.1046/j.1365-2141.1996.352889.x.CrossRefPubMed
7.
Cocks K, Cohen D, Wisloff F, Sezer O, Lee S, Hippe E, Gimsing P, Turesson I, Hajek R, Smith A: An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma. European journal of cancer (Oxford, England: 1990). 2007, 43: 1670-1678. 10.1016/j.ejca.2007.04.022.CrossRef
8.
Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC: Assessing symptom distress in cancer patients: the M.D. Anderson Symptom Inventory. Cancer. 2000, 89: 1634-1646. 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V.CrossRefPubMed
9.
Dubois D, Dhawan R, van de Velde H, Esseltine D, Gupta S, Viala M, de la Loge C: Descriptive and prognostic value of patient-reported outcomes: the bortezomib experience in relapsed and refractory multiple myeloma. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2006, 24: 976-982. 10.1200/JCO.2005.04.0824.CrossRef
10.
Wagner LI, Robinson D, Weiss M, Katz M, Greipp P, Fonseca R, Cella D: Content development for the functional assessment of cancer therapy-multiple myeloma: Use of qualitative and quantitative methods for scale construction. J Pain Symptom Manage. 2012, 43: 1094-1104. 10.1016/j.jpainsymman.2011.06.019.PubMedCentralCrossRefPubMed
11.
Kirkova J, Davis MP, Walsh D, Tiernan E, O’Leary N, LeGrand SB, Lagman RL, Russell KM: Cancer symptom assessment instruments: a systematic review. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2006, 24: 1459-1473. 10.1200/JCO.2005.02.8332.CrossRef
12.
Gning I, Trask PC, Mendoza TR, Harle MT, Gutierrez KA, Kitaka SA, Sherman SI, Cleeland CS: Development and initial validation of the thyroid cancer module of the M. D. Anderson Symptom Inventory. Oncology. 2009, 76: 59-68. 10.1159/000178809.CrossRefPubMed
13.
Armstrong TS, Mendoza T, Gning I, Coco C, Cohen MZ, Eriksen L, Hsu MA, Gilbert MR, Cleeland C: Validation of the M.D. Anderson Symptom Inventory Brain Tumor Module (MDASI-BT). Journal of neuro-oncology. 2006, 80: 27-35. 10.1007/s11060-006-9135-z.CrossRefPubMed
14.
Mendoza TR, Wang XS, Lu C, Palos GR, Liao Z, Mobley GM, Kapoor S, Cleeland CS: Measuring the symptom burden of lung cancer: the validity and utility of the lung cancer module of the M. D. Anderson Symptom Inventory. The oncologist. 2011, 16: 217-227. 10.1634/theoncologist.2010-0193.PubMedCentralCrossRefPubMed
15.
Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS, Weber RS, Lewin JS, Garden AS, Ang KK: Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module. Head Neck. 2007, 29: 923-931. 10.1002/hed.20602.CrossRefPubMed
16.
Willis GRB, Barofsky I: The use of cognitive interviewing techniques in quality of life and patient-reported outcomes assessment. Outcomes Assessment in Cancer: Measures, Methods, and Applications. Edited by: Lipscomb J, Gotay CC, Snyder C. 2005, Cambridge: Cambridge University Press, 610-622.
17.
Serlin RC, Mendoza TR, Nakamura Y, Edwards KR, Cleeland CS: When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain. 1995, 61: 277-284. 10.1016/0304-3959(94)00178-H.CrossRefPubMed
18.
Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL: The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999, 85: 1186-1196. 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N.CrossRefPubMed
19.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC: The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993, 85: 365-376. 10.1093/jnci/85.5.365.CrossRefPubMed
20.
Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982, 5: 649-655. 10.1097/00000421-198212000-00014.CrossRefPubMed
21.
Cleeland CS, Gonin R, Baez L, Loehrer P, Pandya KJ: Pain and treatment of pain in minority patients with cancer. The Eastern Cooperative Oncology Group Minority Outpatient Pain Study. Annals of internal medicine. 1997, 127: 813-816.CrossRefPubMed
22.
Cleeland CS, Gonin R, Hatfield AK, Edmonson JH, Blum RH, Stewart JA, Pandya KJ: Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994, 330: 592-596. 10.1056/NEJM199403033300902.CrossRefPubMed
23.
Nunnally J, Bernstein IH: Pscyhometric Theory. 1994, New York: McGraw-Hill, 3
24.
Sloan JA, Vargas-Chanes D, Kamath CC, Sargent DJ, Novotny PJ, Atherton P: Detecting worms, ducks and elephants: A simple approach for defining clinically relevant effects in qualty-of-life measures. J Cancer Integr Med. 2003, 1 (1): 41-47.
25.
Cohen J: Statistical Power Analysis for the Behavioral Sciences. 1988, NJ: Lawrence Earlbaum Associates, 2
26.
27.
Efficace F, Novik A, Vignetti M, Mandelli F, Cleeland CS: Health-related quality of life and symptom assessment in clinical research of patients with hematologic malignancies: where are we now and where do we go from here?. Haematologica. 2007, 92: 1596-1598. 10.3324/haematol.11710.CrossRefPubMed
28.
Fairclough DL: Patient reported outcomes as endpoints in medical research. Stat Methods Med Res. 2004, 13: 115-138. 10.1191/0962280204sm357ra.CrossRefPubMed
29.
Mystakidou K, Cleeland C, Tsilika E, Katsouda E, Primikiri A, Parpa E, Vlahos L, Mendoza T: Greek M.D. Anderson Symptom Inventory: validation and utility in cancer patients. Oncology. 2004, 67: 203-210. 10.1159/000081318.CrossRefPubMed
30.
Nejmi M, Wang XS, Mendoza TR, Gning I, Cleeland CS: Validation and application of the Arabic version of the M. D. Anderson symptom inventory in Moroccan patients with cancer. Journal of pain and symptom management. 2010, 40: 75-86. 10.1016/j.jpainsymman.2009.12.007.CrossRefPubMed
31.
Okuyama T, Wang XS, Akechi T, Mendoza TR, Hosaka T, Cleeland CS, Uchitomi Y: Japanese version of the MD Anderson Symptom Inventory: a validation study. J Pain Symptom Manage. 2003, 26: 1093-1104. 10.1016/j.jpainsymman.2003.05.003.CrossRefPubMed
32.
Wang XS, Wang Y, Guo H, Mendoza TR, Hao XS, Cleeland CS: Chinese version of the M. D. Anderson Symptom Inventory: validation and application of symptom measurement in cancer patients. Cancer. 2004, 101: 1890-1901. 10.1002/cncr.20448.CrossRefPubMed
33.
Yun YH, Mendoza TR, Kang IO, You CH, Roh JW, Lee CG, Lee WS, Lee KS, Bang SM, Park SM: Validation study of the Korean version of the M. D. Anderson Symptom Inventory. Journal of pain and symptom management. 2006, 31: 345-352. 10.1016/j.jpainsymman.2005.07.013.CrossRefPubMed
Metadata
Title
Validation of the M. D. Anderson Symptom Inventory multiple myeloma module
Authors
Desiree Jones
Elisabeth G Vichaya
Xin Shelley Wang
Loretta A Williams
Nina D Shah
Sheeba K Thomas
Valen E Johnson
Richard E Champlin
Charles S Cleeland
Tito R Mendoza
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2013
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-6-13

Other articles of this Issue 1/2013

Journal of Hematology & Oncology 1/2013 Go to the issue

Research

Epigenetic inactivation of the MIR129-2 in hematological malignancies

Review

The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies

Review

Immunomodulation therapy with lenalidomide in follicular, transformed and diffuse large B cell lymphoma: current data on safety and efficacy

Review

MEK and the inhibitors: from bench to bedside

Research

Monitoring of minimal residual disease (MRD) is useful to predict prognosis of adult patients with Ph-negative ALL: results of a prospective study (ALL MRD2002 Study)

Review

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits