Skip to main content
Top
Published in: Journal of Hematology & Oncology 1/2012

Open Access 01-12-2012 | Letter to the Editor

Tissue doppler echocardiography detects preclinical markers of cardiac lesion in MDS patients

Authors: Cláudio César Monteiro de Castro, Carlos Bellini Gondim Gomes, Manoel Ricardo Alves Martins, Juliana Cordeiro de Sousa, Silvia MM Magalhaes, Ronald F Pinheiro

Published in: Journal of Hematology & Oncology | Issue 1/2012

Login to get access

Abstract

Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder of elderly people. Cardiac dysfunction is a marker of grim prognosis in MDS. We evaluated cardiac dysfunction of MDS patients with or without transfusion dependency by tissue doppler echocardiography. We found the average values of ventricular end-systolic and end-diastolic volumes in transfusion dependency MDS group higher than others. These results were strongly correlated to hemoglobin levels. Tissue Doppler Echocardiography should be routinely performed in MDS patients to detect preclinical cardiac alterations and prevent more heart insults in this group of chronic anemic aged patients.
Appendix
Available only for authorised users
Literature
1.
go back to reference Cazzola M, Della Porta MG, Travaglino E, Malcovati L: Classification and prognostic evaluation of myelodysplastic syndromes. Semin Oncol. 2011, 38 (Suppl 5): 627-634.CrossRefPubMed Cazzola M, Della Porta MG, Travaglino E, Malcovati L: Classification and prognostic evaluation of myelodysplastic syndromes. Semin Oncol. 2011, 38 (Suppl 5): 627-634.CrossRefPubMed
2.
go back to reference Naqvi K, Garcia-Manero G, Sardesai S, Oh J, Vigil CE, Pierce S, Lei X, Shan J, Kantarjian HM, Suarez-Almazor ME: Association of comorbidities with overall survival in myelodysplastic syndrome: development of a prognostic model. J Clin Oncol. 2011, 29: 2240-2246. 10.1200/JCO.2010.31.3353.PubMedCentralCrossRefPubMed Naqvi K, Garcia-Manero G, Sardesai S, Oh J, Vigil CE, Pierce S, Lei X, Shan J, Kantarjian HM, Suarez-Almazor ME: Association of comorbidities with overall survival in myelodysplastic syndrome: development of a prognostic model. J Clin Oncol. 2011, 29: 2240-2246. 10.1200/JCO.2010.31.3353.PubMedCentralCrossRefPubMed
3.
go back to reference Malcovati L, Porta MG, Pascutto C, Invernizzi R, Boni M, Travaglino E, Passamonti F, Arcaini L, Maffioli M, Bernasconi P, Lazzarino : Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J Clin Oncol. 2005, 20 (Suppl 30): 7594-7603.CrossRef Malcovati L, Porta MG, Pascutto C, Invernizzi R, Boni M, Travaglino E, Passamonti F, Arcaini L, Maffioli M, Bernasconi P, Lazzarino : Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J Clin Oncol. 2005, 20 (Suppl 30): 7594-7603.CrossRef
4.
go back to reference Carmer R: Anemia and aging: an overview of clinical, diagnostic and biological issues. Blood Rev. 2001, 15: 9-18. 10.1054/blre.2001.0146.CrossRef Carmer R: Anemia and aging: an overview of clinical, diagnostic and biological issues. Blood Rev. 2001, 15: 9-18. 10.1054/blre.2001.0146.CrossRef
Metadata
Title
Tissue doppler echocardiography detects preclinical markers of cardiac lesion in MDS patients
Authors
Cláudio César Monteiro de Castro
Carlos Bellini Gondim Gomes
Manoel Ricardo Alves Martins
Juliana Cordeiro de Sousa
Silvia MM Magalhaes
Ronald F Pinheiro
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2012
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-5-30

Other articles of this Issue 1/2012

Journal of Hematology & Oncology 1/2012 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine