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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2011

Open Access 01-12-2011 | Review

Endothelial progenitor cell biology in disease and tissue regeneration

Authors: Andrea L George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman, Raj K Tiwari

Published in: Journal of Hematology & Oncology | Issue 1/2011

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Abstract

Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.
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Metadata
Title
Endothelial progenitor cell biology in disease and tissue regeneration
Authors
Andrea L George
Pradeep Bangalore-Prakash
Shilpi Rajoria
Robert Suriano
Arulkumaran Shanmugam
Abraham Mittelman
Raj K Tiwari
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2011
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-4-24

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