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Journal of Medical Case Reports

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Open Access 01-12-2015 | Case report

Iterative and prolonged remission in metastatic breast cancer using pegylated irinotecan: a case report

Authors: Mounia Amzerin, Maha Mokrim, Hassan Errihani, Martine J Piccart

Published in: Journal of Medical Case Reports | Issue 1/2015

Abstract

Introduction

Pegylated irinotecan NKTR-102 is a topoisomerase I inhibitor-polymer conjugate. This new formulation of irinotecan has been evaluated in a phase II clinical trial and is showing remarkable activity. To the best of our knowledge, this is the first case report of an impressive iterative response to pegylated irinotecan NKTR-102 in metastatic breast cancer.

Case presentation

We report the case of a 49-year-old Caucasian woman diagnosed with metastatic luminal A breast cancer with initial bone followed by liver and bone marrow metastases, treated with three lines of hormonal therapy, targeted therapy and six lines of chemotherapy. She showed no major response to conventional treatment, whereas, the tumor shrinkage under pegylated irinotecan NKTR-102 was impressive, durable and iterative.

Conclusions

Reintroduction of an active drug is a valid approach as illustrated by our case. The results of the current phase III trials of pegylated irinotecan NKTR-102 are eagerly awaited.

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Title: Iterative and prolonged remission in metastatic breast cancer using pegylated irinotecan: a case report
Authors: Mounia Amzerin
Maha Mokrim
Hassan Errihani
Martine J Piccart
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-9-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Iterative and prolonged remission in metastatic breast cancer using pegylated irinotecan: a case report

Abstract

Introduction

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

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