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Open Access 01-12-2014 | Case report

Anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion: a case report

Authors: Tomoe Abe, Masaru Suzuki, Kaoruko Shimizu, Naofumi Shinagawa, Satoshi Oizumi, Yoshihiro Matsuno, Masaya Miyazaki, Mishie Tanino, Shinya Tanaka, Masaharu Nishimura

Published in: Journal of Medical Case Reports | Issue 1/2014

Abstract

Introduction

Anaplastic transformation of well-differentiated papillary thyroid carcinoma at distant metastasis sites is rare. To the best of our knowledge, this is the first report of an autopsy case of anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion.

Case presentation

We report an autopsy case of a 61-year-old Japanese man with anaplastic transformation of papillary thyroid carcinoma with multiple lung metastases presenting with a malignant pleural effusion, which was difficult to diagnose by cytological examination before the autopsy. He presented with a 1-month history of progressive dyspnea, and examination of the left pleural effusion revealed a bloody exudate with an increase in thyroglobulin; however, malignant cells in the pleural fluid were negative for thyroglobulin.

Conclusion

It is important to be aware that anaplastic transformation of differentiated thyroid carcinoma could develop in lung metastases and could be a cause of a malignant pleural effusion.

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Title: Anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion: a case report
Authors: Tomoe Abe
Masaru Suzuki
Kaoruko Shimizu
Naofumi Shinagawa
Satoshi Oizumi
Yoshihiro Matsuno
Masaya Miyazaki
Mishie Tanino
Shinya Tanaka
Masaharu Nishimura
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2014
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-8-460

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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