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Published in: Journal of Medical Case Reports 1/2014

Open Access 01-12-2014 | Case report

Combined myoepithelial carcinoma and myoepithelioma in soft tissue: a case report and review of the literature

Authors: Youssef Mahdi, Fouad Zouaidia, Abdelilah Zouhair, Mohamed Azouz, Kaoutar Znati, Ahmed Jahid, Mohamed Saleh Berrada, Zakiya Bernoussi, Fatima Mansouri, Moradh el Yaacoubi, Najat Mahassini

Published in: Journal of Medical Case Reports | Issue 1/2014

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Abstract

Introduction

Soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. They were incorporated into the World Health Organization classification of soft tissue tumors in 2002. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. To the best of our knowledge, such an association has never been reported in the literature.

Case presentation

We report a case of myoepithelial carcinoma combined with myoepithelioma occurring in the soft tissue of the right forearm of an 84-year-old Arabian man. We describe the clinical, radiological and pathological features dominated by histological polymorphism. We will also describe the proposed histological criteria of malignancy and the major role of immunohistochemistry in positive and differential diagnosis. We finally mention the therapeutic arsenal available.

Conclusion

Through this work, we report that myoepithelioma of soft tissue can progress to malignant myoepithelioma.
Appendix
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Literature
1.
go back to reference Lee JR, Georgi DE, Wang BY: Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature. Ann Pathol. 2007, 11 (3): 190-198. 10.1016/j.anndiagpath.2006.04.004.CrossRef Lee JR, Georgi DE, Wang BY: Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature. Ann Pathol. 2007, 11 (3): 190-198. 10.1016/j.anndiagpath.2006.04.004.CrossRef
2.
go back to reference Gleason BC, Hornick JL: Myoepithelial tumors of skin and soft tissue: an update. Diagn Histopathol. 2008, 14: 552-562. 10.1016/j.mpdhp.2008.08.005.CrossRef Gleason BC, Hornick JL: Myoepithelial tumors of skin and soft tissue: an update. Diagn Histopathol. 2008, 14: 552-562. 10.1016/j.mpdhp.2008.08.005.CrossRef
3.
go back to reference Château F, Nguyen P, Guinard D: Soft tissue myoepithelioma of the ring finger of the right hand with intraosseous extension: a case report. Chir Main. 2011, 30 (2): 144-147. 10.1016/j.main.2011.01.011.CrossRefPubMed Château F, Nguyen P, Guinard D: Soft tissue myoepithelioma of the ring finger of the right hand with intraosseous extension: a case report. Chir Main. 2011, 30 (2): 144-147. 10.1016/j.main.2011.01.011.CrossRefPubMed
4.
go back to reference Burke T, Sahin A, Johnson DE, Ordonez NG, Mackay B: Myoepithelioma of the retroperitoneum. Ultrastruct Pathol. 1995, 19: 269-274. 10.3109/01913129509064230.CrossRefPubMed Burke T, Sahin A, Johnson DE, Ordonez NG, Mackay B: Myoepithelioma of the retroperitoneum. Ultrastruct Pathol. 1995, 19: 269-274. 10.3109/01913129509064230.CrossRefPubMed
5.
go back to reference Hornick JL, Fletcher CD: Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J SurgPathol. 2003, 27: 1183-1196.CrossRef Hornick JL, Fletcher CD: Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J SurgPathol. 2003, 27: 1183-1196.CrossRef
6.
go back to reference Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors: a molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010, 49 (12): 1114-1124. 10.1002/gcc.20819.CrossRefPubMedPubMedCentral Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD: EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors: a molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010, 49 (12): 1114-1124. 10.1002/gcc.20819.CrossRefPubMedPubMedCentral
7.
go back to reference Aparicio MA, Lopez-Barea F, Cruz JJ, Garcia Macias MC, Hernandez T, de Alava E: Soft tissue myoepithelial carcinoma without EWSR1 gene rearrangement and poor outcome: a case report. Rev Esp Patol. 2012, 45: 58-63. Aparicio MA, Lopez-Barea F, Cruz JJ, Garcia Macias MC, Hernandez T, de Alava E: Soft tissue myoepithelial carcinoma without EWSR1 gene rearrangement and poor outcome: a case report. Rev Esp Patol. 2012, 45: 58-63.
8.
go back to reference Flucke U, Mentzel T, Verdijk MA, Slootweg PJ, Creytens DH, Suurmeijer AJ, Tops BB: EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report. Hum Pathol. 2012, 43 (5): 764-768. 10.1016/j.humpath.2011.08.004.CrossRefPubMed Flucke U, Mentzel T, Verdijk MA, Slootweg PJ, Creytens DH, Suurmeijer AJ, Tops BB: EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report. Hum Pathol. 2012, 43 (5): 764-768. 10.1016/j.humpath.2011.08.004.CrossRefPubMed
9.
go back to reference Kilpatrick SE, Hitchcock MG, Kraus MD, Calonje E, Fletcher CD: Mixed tumors and myoepitheliomas of soft tissue: a clinicopathologic study of 19 cases with a unifying concept. Am J SurgPathol. 1997, 21 (1): 13-22.CrossRef Kilpatrick SE, Hitchcock MG, Kraus MD, Calonje E, Fletcher CD: Mixed tumors and myoepitheliomas of soft tissue: a clinicopathologic study of 19 cases with a unifying concept. Am J SurgPathol. 1997, 21 (1): 13-22.CrossRef
10.
go back to reference Noronha V, Cooper DL, Higgins SA, Murren JR, Kluger HM: Metastatic myoepithelial carcinoma of the vulva treated with carboplatin and paclitaxel. Lancet Oncol. 2006, 7 (3): 270-271. 10.1016/S1470-2045(06)70619-2.CrossRefPubMed Noronha V, Cooper DL, Higgins SA, Murren JR, Kluger HM: Metastatic myoepithelial carcinoma of the vulva treated with carboplatin and paclitaxel. Lancet Oncol. 2006, 7 (3): 270-271. 10.1016/S1470-2045(06)70619-2.CrossRefPubMed
Metadata
Title
Combined myoepithelial carcinoma and myoepithelioma in soft tissue: a case report and review of the literature
Authors
Youssef Mahdi
Fouad Zouaidia
Abdelilah Zouhair
Mohamed Azouz
Kaoutar Znati
Ahmed Jahid
Mohamed Saleh Berrada
Zakiya Bernoussi
Fatima Mansouri
Moradh el Yaacoubi
Najat Mahassini
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2014
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-8-317

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