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Journal of Medical Case Reports

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Open Access 01-12-2014 | Case report

Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

Authors: Toyomitsu Sawai, Yasuhiro Umeyama, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Shigeru Kohno

Published in: Journal of Medical Case Reports | Issue 1/2014

Abstract

Introduction

Pulmonary alveolar proteinosis is a rare pulmonary disease characterized by excessive alveolar accumulation of surfactant due to defective alveolar clearance by macrophages. There are only a few published case reports of pulmonary alveolar proteinosis occurring in association with solid cancers. To the best of our knowledge, there are no previously reported cases of pulmonary alveolar proteinosis associated with breast cancer.

Case presentation

A 48-year-old Asian woman, a nonsmoker, presented to our institution with a right breast mass. Biopsy examination of the lesion revealed scirrhous carcinoma. A chest computed tomography scan for metastases showed abnormal shadows in both upper lung fields. As a result of flexible fiberscopic bronchoscopy, this patient was diagnosed as having pulmonary alveolar proteinosis. This case was categorized as autoimmune pulmonary alveolar proteinosis due to the positive anti-granulocyte-macrophage colony-stimulating factor antibody. Pulmonary alveolar proteinosis decreased gradually after mastectomy.

Conclusions

The present case involved the coincident occurrence of autoimmune pulmonary alveolar proteinosis with breast cancer; breast cancer may be a factor during pulmonary alveolar proteinosis development.

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Title: Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report
Authors: Toyomitsu Sawai
Yasuhiro Umeyama
Sumako Yoshioka
Nobuko Matsuo
Naofumi Suyama
Shigeru Kohno
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2014
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-8-279

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

Abstract

Introduction

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

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