Top

Journal of Medical Case Reports

Published in:

Open Access 01-12-2014 | Case report

Incomplete duplication of a lower extremity (polymelia): a case report

Authors: Nelson Montalvo, Ligia Redrobán, Victor Hugo Espín

Published in: Journal of Medical Case Reports | Issue 1/2014

Abstract

Introduction

Polymelia, or congenital duplication of a limb, is an extremely rare entity in humans, with few cases reported in the literature.

Case presentation

We present the case of a six-month-old Hispanic boy born with a lower limb bud on the left posterior thigh.

Conclusion

The infant had a favorable outcome and evolution after surgical treatment of his supernumerary limb, with no after-effects or impairment whatsoever.

Available only for authorised users

Bannykh SI, Bannykh GI, Mannino FL, Jones KL, Hansen L, Benirschke K, Masliah E: Partial caudal duplication in a newborn associated with meningomyelocele and complex heart anomaly. Teratology. 2001, 63: 94-99. 10.1002/1096-9926(200102)63:2<94::AID-TERA1015>3.0.CO;2-A.CrossRefPubMed

Gómez Dumm C: Skeletal system and limbs in human embryology. Human Embryology: Atlas and Text [in Spanish]. 2003, Buenos Aires, Argentina: El Ateneo, 198-200.

Brook WJ, Díaz-Benjumea FJ, Cohen SM: Organizing spatial pattern in limb development. Annu Rev Cell Dev Biol. 1996, 12: 161-180. 10.1146/annurev.cellbio.12.1.161.CrossRefPubMed

Langman J: Skeletal system. Medical Embryology. Edited by: Sadler TW. 1982, Baltimore: Williams & Wilkins, 129-143. 4

Moore KL, Persaud TVN: Skeletal system in the developing human. The Developing Human: Clinically Oriented Embryology. 2003, Philadelphia, PA: Saunders, 405-422. 7

Cohn MJ, Izpisúa-Belmonte JC, Abud H, Heath JK, Tickle C: Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell. 1995, 80: 739-746. 10.1016/0092-8674(95)90352-6.CrossRefPubMed

Crossley PH, Minowada G, MacArthur CA, Martin GR: Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell. 1996, 84: 127-136. 10.1016/S0092-8674(00)80999-X.CrossRefPubMed

Ohuchi H, Nakagawa T, Yamamoto A, Araga A, Ohata T, Ishimaru Y, Yoshioka H, Kuwana T, Nohno T, Yamasaki M, Itoh N, Noji S: The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development. 1997, 124: 2235-2244.PubMed

Winter RM, Donnai D: A possible human homologue for the mouse mutant disorganisation. J Med Genet. 1989, 26: 417-420. 10.1136/jmg.26.7.417.CrossRefPubMedPubMedCentral

10.

Norman WH: A child with three lower extremities. J Bone Joint Surg Am. 1964, 46: 1755-1758.PubMed

11.

Hanley EN, Stanitski CL: Incomplete congenital duplication of a lower extremity: a case report. J Bone Joint Surg Am. 1980, 62: 479-481.PubMed

12.

Acharya S, Pradhan NK, Rao PT: Congenital incomplete reduplication of the lower limb: a case report. Int Orthop. 1993, 17: 308-309.CrossRefPubMed

13.

Vogel A, Rodriguez C, Izpisúa-Belmonte JC: Involvement of FGF-8 in initiation outgrowth and patterning of the vertebrate limb. Development. 1996, 122: 1737-1750.PubMed

14.

Cohn MJ, Patel K, Krumlauf R, Wilkinson DG, Clarke JD, Tickle C: Hox9 genes and vertebrate limb specification. Nature. 1997, 387: 97-101. 10.1038/387097a0.CrossRefPubMed

15.

García-Espinosa I, García-Cruz R, Huerta-Mendoza H, Cabrera-Hernández R, Merelo-Villafán I, López-Alfonso A: [Polymelia: case report and review of the literature] [in Spanish]. Acta Ortop Mex. 2002, 16: 272-275.

Title: Incomplete duplication of a lower extremity (polymelia): a case report
Authors: Nelson Montalvo
Ligia Redrobán
Victor Hugo Espín
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2014
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-8-184

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Incomplete duplication of a lower extremity (polymelia): a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2014

Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report

Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report

An effective 5-fluorouracil, levofolinate, and oxaliplatin therapy for recurrent breast cancer: a case report

Intra-articular angioleiomyoma of the knee with an atypical finding on gadolinium-enhanced magnetic resonance imaging: a case report

Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature

Postpartum woman with pneumomediastinum and reverse (inverted) takotsubo cardiomyopathy: a case report