Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2013

Open Access 01-12-2013 | Case report

Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a case report

Authors: Yueh-Shih Chang, Ling Yeung, Liang-Che Chang, Jen-Seng Huang, Kun-Yun Yeh

Published in: Journal of Medical Case Reports | Issue 1/2013

Login to get access

Abstract

Introduction

The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life.

Case presentation

A 63-year-old Chinese woman initially presented to our facility with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of the lung (T2bN2M1b, stage IV). A thorough ophthalmologic evaluation, study of our patient’s history, imaging studies and comprehensive immunohistochemical staining tests led to the diagnosis of this rare lung tumor.

Conclusions

Although this uncommon cancer is unfortunately already at a late stage when choroid metastases develop, systemic chemotherapy alone is sufficient to preserve vision and gain control over the disease.
Appendix
Available only for authorised users
Literature
1.
go back to reference Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE: Survey of 520 eyes with uveal metastases. Ophthalmology. 1997, 104: 1265-1276. 10.1016/S0161-6420(97)30148-1.CrossRefPubMed Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE: Survey of 520 eyes with uveal metastases. Ophthalmology. 1997, 104: 1265-1276. 10.1016/S0161-6420(97)30148-1.CrossRefPubMed
2.
go back to reference Ascaso FJ, Castillo JM, Garcia FJ, Cristobal JA, Fuertes A, Artal A: Bilateral choroidal metastases revealing an advanced non-small cell lung cancer. Ann Thorac Surg. 2009, 88: 1013-1015. 10.1016/j.athoracsur.2009.02.019.CrossRefPubMed Ascaso FJ, Castillo JM, Garcia FJ, Cristobal JA, Fuertes A, Artal A: Bilateral choroidal metastases revealing an advanced non-small cell lung cancer. Ann Thorac Surg. 2009, 88: 1013-1015. 10.1016/j.athoracsur.2009.02.019.CrossRefPubMed
3.
go back to reference Salah S, Khader J, Yousef Y, Salem A, Al-Hussaini M, Al-Asady R: Choroidal metastasis as the sole initial presentation of metastatic lung cancer. Hematol Oncol Stem Cell Ther. 2012, 5: 60-65.CrossRefPubMed Salah S, Khader J, Yousef Y, Salem A, Al-Hussaini M, Al-Asady R: Choroidal metastasis as the sole initial presentation of metastatic lung cancer. Hematol Oncol Stem Cell Ther. 2012, 5: 60-65.CrossRefPubMed
4.
go back to reference Singh N, Kulkarni P, Aggarwal AN, Rai Mittal B, Gupta N, Behera D, Gupta A: Choroidal metastasis as a presenting manifestation of lung cancer: a report of 3 cases and systematic review of the literature. Medicine (Baltimore). 2012, 91: 179-194. 10.1097/MD.0b013e3182574a0b.CrossRef Singh N, Kulkarni P, Aggarwal AN, Rai Mittal B, Gupta N, Behera D, Gupta A: Choroidal metastasis as a presenting manifestation of lung cancer: a report of 3 cases and systematic review of the literature. Medicine (Baltimore). 2012, 91: 179-194. 10.1097/MD.0b013e3182574a0b.CrossRef
5.
go back to reference Arevalo JF, Fernandez CF, Garcia RA: Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology. 2005, 112: 1612-1619. 10.1016/j.ophtha.2005.03.030.CrossRefPubMed Arevalo JF, Fernandez CF, Garcia RA: Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology. 2005, 112: 1612-1619. 10.1016/j.ophtha.2005.03.030.CrossRefPubMed
6.
go back to reference Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J. 2001, 18: 1059-1068. 10.1183/09031936.01.00275301.CrossRefPubMed Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J. 2001, 18: 1059-1068. 10.1183/09031936.01.00275301.CrossRefPubMed
7.
go back to reference Terada T: Primary clear cell adenocarcinoma of the lung. Med Oncol. 2011, 28 (Suppl 1): 593-595.CrossRef Terada T: Primary clear cell adenocarcinoma of the lung. Med Oncol. 2011, 28 (Suppl 1): 593-595.CrossRef
8.
go back to reference Kreusel KM, Wiegel T, Stange M, Bornfeld N, Hinkelbein W, Foerster MH: Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 2002, 134: 445-447. 10.1016/S0002-9394(02)01580-5.CrossRefPubMed Kreusel KM, Wiegel T, Stange M, Bornfeld N, Hinkelbein W, Foerster MH: Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 2002, 134: 445-447. 10.1016/S0002-9394(02)01580-5.CrossRefPubMed
9.
go back to reference Wang TJ, Yang CM, Ho TC, Huang JS, Lin CP, Yang CH, Chen MS, Lin LL: Metastatic choroidal tumors in Taiwan: an 11-year experience. Am J Ophthalmol. 2005, 140: 735-737. 10.1016/j.ajo.2005.03.068.CrossRefPubMed Wang TJ, Yang CM, Ho TC, Huang JS, Lin CP, Yang CH, Chen MS, Lin LL: Metastatic choroidal tumors in Taiwan: an 11-year experience. Am J Ophthalmol. 2005, 140: 735-737. 10.1016/j.ajo.2005.03.068.CrossRefPubMed
10.
go back to reference Fan WC, Yu CJ, Tsai CM, Huang MS, Lai CL, Hsia TC, Tien YJ, Huang SF, Wu CH, Chou KT, Lee YC, Perng RP, Chen YM: Different efficacies of erlotinib and gefitinib in taiwanese patients with advanced non-small cell lung cancer: a retrospective multicenter study. J Thorac Oncol. 2011, 6: 148-155. 10.1097/JTO.0b013e3181f77b27.CrossRefPubMed Fan WC, Yu CJ, Tsai CM, Huang MS, Lai CL, Hsia TC, Tien YJ, Huang SF, Wu CH, Chou KT, Lee YC, Perng RP, Chen YM: Different efficacies of erlotinib and gefitinib in taiwanese patients with advanced non-small cell lung cancer: a retrospective multicenter study. J Thorac Oncol. 2011, 6: 148-155. 10.1097/JTO.0b013e3181f77b27.CrossRefPubMed
11.
go back to reference Battikh MH, Ben Yahia S, Ben Sayah MM, Maatallah A, Joobeur S, Rouatbi N, Khairallah M, El Kamel A: Choroid metastases revealing pulmonary adenocarcioma resolved with chemotherapy. Rev Pneumol Clin. 2004, 60: 353-356. 10.1016/S0761-8417(04)72149-5.CrossRefPubMed Battikh MH, Ben Yahia S, Ben Sayah MM, Maatallah A, Joobeur S, Rouatbi N, Khairallah M, El Kamel A: Choroid metastases revealing pulmonary adenocarcioma resolved with chemotherapy. Rev Pneumol Clin. 2004, 60: 353-356. 10.1016/S0761-8417(04)72149-5.CrossRefPubMed
12.
go back to reference Shields JA, Perez N, Shields CL, Foxman S, Foxman B: Simultaneous choroidal and brain metastasis as initial manifestations of lung cancer. Ophthalmic Surg Lasers. 2002, 33: 323-325.PubMed Shields JA, Perez N, Shields CL, Foxman S, Foxman B: Simultaneous choroidal and brain metastasis as initial manifestations of lung cancer. Ophthalmic Surg Lasers. 2002, 33: 323-325.PubMed
13.
go back to reference Einhorn LH: First-line chemotherapy for non-small-cell lung cancer: is there a superior regimen based on histology?. J Clin Oncol. 2008, 26: 3485-3486. 10.1200/JCO.2008.17.2056.CrossRefPubMed Einhorn LH: First-line chemotherapy for non-small-cell lung cancer: is there a superior regimen based on histology?. J Clin Oncol. 2008, 26: 3485-3486. 10.1200/JCO.2008.17.2056.CrossRefPubMed
Metadata
Title
Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a case report
Authors
Yueh-Shih Chang
Ling Yeung
Liang-Che Chang
Jen-Seng Huang
Kun-Yun Yeh
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2013
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-7-267

Other articles of this Issue 1/2013

Journal of Medical Case Reports 1/2013 Go to the issue