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Journal of Medical Case Reports

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Open Access 01-12-2012 | Case report

Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report

Authors: Maximilian Gahr, Regina Gastl, Markus A Kölle, Carlos Schönfeldt-Lecuona, Roland W Freudenmann

Published in: Journal of Medical Case Reports | Issue 1/2012

Abstract

Introduction

There are limited treatment options for people with schizophrenia with cytochrome P450 2D6 ultrarapid metabolizer status who do not respond to amisulpride.

Furthermore, the literature does not provide evidence-based guidelines for this particular constellation.

Case presentation

We report the case of a 50-year-old Caucasian female patient with schizophrenia and cytochrome P450 2D6 ultrarapid metabolizer status who experienced an insufficient antipsychotic effect with amisulpride. She was successfully treated with melperone-augmented haloperidol.

Conclusion

This report yields melperone-augmented haloperidol as a possible pharmacological strategy in the described situation. In addition, our observations support the available evidence for the potential of melperone to act as an inhibitor of cytochrome P450 2D6.

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Title: Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report
Authors: Maximilian Gahr
Regina Gastl
Markus A Kölle
Carlos Schönfeldt-Lecuona
Roland W Freudenmann
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-6-49

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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