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Open Access 01-12-2012 | Case report

Towards real-time metabolic profiling of a biopsy specimen during a surgical operation by ¹H high resolution magic angle spinning nuclear magnetic resonance: a case report

Authors: Martial Piotto, François-Marie Moussallieh, Agnès Neuville, Jean-Pierre Bellocq, Karim Elbayed, Izzie Jacques Namer

Published in: Journal of Medical Case Reports | Issue 1/2012

Abstract

Introduction

Providing information on cancerous tissue samples during a surgical operation can help surgeons delineate the limits of a tumoral invasion more reliably. Here, we describe the use of metabolic profiling of a colon biopsy specimen by high resolution magic angle spinning nuclear magnetic resonance spectroscopy to evaluate tumoral invasion during a simulated surgical operation.

Case presentation

Biopsy specimens (n = 9) originating from the excised right colon of a 66-year-old Caucasian women with an adenocarcinoma were automatically analyzed using a previously built statistical model.

Conclusions

Metabolic profiling results were in full agreement with those of a histopathological analysis. The time-response of the technique is sufficiently fast for it to be used effectively during a real operation (17 min/sample). Metabolic profiling has the potential to become a method to rapidly characterize cancerous biopsies in the operation theater.

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Title: Towards real-time metabolic profiling of a biopsy specimen during a surgical operation by 1H high resolution magic angle spinning nuclear magnetic resonance: a case report
Authors: Martial Piotto
François-Marie Moussallieh
Agnès Neuville
Jean-Pierre Bellocq
Karim Elbayed
Izzie Jacques Namer
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-6-22

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Towards real-time metabolic profiling of a biopsy specimen during a surgical operation by ¹H high resolution magic angle spinning nuclear magnetic resonance: a case report

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Introduction

Case presentation

Conclusions

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