Top

Journal of Medical Case Reports

Published in:

Open Access 01-12-2011 | Case report

Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review

Authors: Austin Chen, Samuel Chmell

Published in: Journal of Medical Case Reports | Issue 1/2011

Abstract

Introduction

Heterotopic ossification is the abnormal formation of lamellar bone in soft tissue. Its presence jeopardizes functional outcome, impairs rehabilitation and increases costs due to subsequent surgical interventions.

Case presentation

We present a case of a 32-year-old African-American man with trisomy 8 mosaicism who developed severe heterotopic ossification of his right extensor mechanism subsequent to repair of a patellar tendon rupture.

Conclusion

To the best of our knowledge there are no prior reports of heterotopic ossification as a complication of patellar tendon repair. This case may suggest an association between trisomy 8 mosaicism and increased risk of heterotopic ossification.

Available only for authorised users

Hannallah D, Peng H, Young B, Usas A, Gearhart B, Huard J: Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model. J Bone Joint Surg Am. 2004, 86-A (1): 80-91.PubMed

Balboni TA, Gobezie R, Mamon HJ: Heterotopic ossification: Pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys. 2006, 65 (5): 1289-1299. 10.1016/j.ijrobp.2006.03.053.CrossRefPubMed

Baird EO, Kang QK: Prophylaxis of heterotopic ossification - an updated review. J Orthop Surg Res. 2009, 4: 12-10.1186/1749-799X-4-12.CrossRefPubMedPubMedCentral

Warren SB, Brooker AF: Intramedullary nailing of tibial nonunions. Clin Orthop Relate Res. 1992, 285: 236-243.

Kosztolanyi G, Buhler EM, Elmiger P, Stalder GR: Trisomy 8 mosaicism. A case report and a proposed list of the clinical features. Eur J Pediatr. 1976, 123 (4): 293-300. 10.1007/BF00444650.CrossRefPubMed

Lai CC, Gorlin RJ: Trisomy 8 syndrome. Clin Orthop Relate Res. 1975, 110: 238-243.CrossRef

Kurtyka ZE, Krzykwa B, Piatkowska E, Radwan M, Pietrzyk JJ: Trisomy 8 mosaicism syndrome. Two cases demonstrating variability in phenotype. Clin Pediatr. 1988, 27 (11): 557-564. 10.1177/000992288802701109.CrossRef

Wisniewska M, Mazurek M: Trisomy 8 mosaicism syndrome. J Appl Genet. 2002, 43 (1): 115-118.PubMed

Chen D, Zhao M, Mundy GR: Bone morphogenetic proteins. Growth Factors. 2004, 22 (4): 233-241. 10.1080/08977190412331279890.CrossRefPubMed

10.

Shore EM, Cook AL, Hahn GV, Kaplan FS, Wozney JM, Wagner MJ, Wells DE: BMP-1 sublocalization on human chromosome 8. Molecular anatomy and orthopaedic implications. Clin Orthop Relate Res. 1995, 311: 199-209.

11.

Board TN, Karva A, Board RE, Gambhir AK, Porter ML: The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty. J Bone Joint Surg Br. 2007, 89 (4): 434-440. 10.1302/0301-620X.89B4.18845.CrossRefPubMed

12.

Strauss JB, Chen SS, Shah AP: Cost of radiotherapy versus NSAID administration for prevention of heterotopic ossification after total hip arthroplasty. Int J Radiat Oncol Biol Phys. 2008, 71 (5): 1460-1464. 10.1016/j.ijrobp.2007.12.006.CrossRefPubMed

Title: Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review
Authors: Austin Chen
Samuel Chmell
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-5-453

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2011

Branch facial nerve trauma after superficial temporal artery biopsy: a case report

Recurrent neck abscesses due to cervical tuberculous lymphadenopathy in an elderly woman post-splenectomy: a case report

Acute lower limb compartment syndrome after Cesarean section: a case report

Appendix perforation in appendix duplication in a man: a case report

An unusual case of a microscopic alveolar adenoma coexisting with lung carcinoma: a case report and review of the literature

Use of an amplatzer vascular plug in embolization of a pulmonary artery aneurysm in a case of hughes-stovin syndrome: a case report