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Published in: Journal of Medical Case Reports 1/2011

Open Access 01-12-2011 | Case report

Ganglioneuroblastoma of the posterior mediastinum: a case report

Authors: Saulat H Fatimi, Samira A Bawany, Awais Ashfaq

Published in: Journal of Medical Case Reports | Issue 1/2011

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Abstract

Introduction

Ganglioneuroblastoma is a rare peripheral neuroblastic tumor that is derived from developing neuronal cells of the sympathetic nervous system, and is found mostly, but not exclusively, in babies and young children.

Case presentation

To the best of our knowledge, there have been no previously reported cases of ganglioneuroblastoma of the mediastinum from Pakistan. We present a case of ganglioneuroblastoma in an eight-year-old Pakistani Sindhi boy incidentally found to have a large posterior mediastinal mass that on biopsy initially looked like ganglioneuroma. He underwent successful excision of the mediastinal mass and remained stable post-operatively. Final pathology findings showed a ganglioneuroblastoma. He has remained free of symptoms on long-term follow-up.

Conclusions

The rarity of this tumor along with its almost exclusive occurrence in the pediatric population necessitates a thorough investigation of patients presenting with a symptomatic mass.
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Literature
1.
go back to reference Gurney JG, Ross JA, Wall DA, Bleyer WA, Severson RK, Robison LL: Infant cancer in the U.S.: histology-specific incidence and trends, 1973 to 1992. J Pediatr Hematol Oncol. 1997, 19: 428-432. 10.1097/00043426-199709000-00004.CrossRefPubMed Gurney JG, Ross JA, Wall DA, Bleyer WA, Severson RK, Robison LL: Infant cancer in the U.S.: histology-specific incidence and trends, 1973 to 1992. J Pediatr Hematol Oncol. 1997, 19: 428-432. 10.1097/00043426-199709000-00004.CrossRefPubMed
2.
go back to reference Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK, (Eds): SEER Cancer Statistics Review, 1975-2006, National Cancer Institute. http://seer.cancer.gov/csr/1975_2006/ Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK, (Eds): SEER Cancer Statistics Review, 1975-2006, National Cancer Institute. http://​seer.​cancer.​gov/​csr/​1975_​2006/​
3.
go back to reference Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK, Castleberry RP: The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999, 86: 364-372. 10.1002/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7.CrossRefPubMed Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK, Castleberry RP: The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999, 86: 364-372. 10.1002/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7.CrossRefPubMed
4.
go back to reference Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM: Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003, 23: 29-43. 10.1148/rg.231025050.CrossRefPubMed Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM: Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003, 23: 29-43. 10.1148/rg.231025050.CrossRefPubMed
5.
go back to reference Lonergan GJ, Schwab CM, Suarez ES, Carlson CL: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002, 22: 911-934.CrossRefPubMed Lonergan GJ, Schwab CM, Suarez ES, Carlson CL: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002, 22: 911-934.CrossRefPubMed
6.
go back to reference Mugishima H, Sakurai M: Symptoms of neuroblastoma: paraneoplastic syndrome. Neuroblastoma. Edited by: Brodeur GM, Savada T, Tsuchida Y, Voute PA. 2000, Amsterdam, The Netherlands: Elsevier Science B.V., 293-296. 1 Mugishima H, Sakurai M: Symptoms of neuroblastoma: paraneoplastic syndrome. Neuroblastoma. Edited by: Brodeur GM, Savada T, Tsuchida Y, Voute PA. 2000, Amsterdam, The Netherlands: Elsevier Science B.V., 293-296. 1
7.
go back to reference Lucky AW, McGuire J, Komp DM: Infantile neuroblastoma presenting with cutaneous blanching nodules. J Am Acad Dermatol. 1982, 6: 389-391. 10.1016/S0190-9622(82)70034-9.CrossRefPubMed Lucky AW, McGuire J, Komp DM: Infantile neuroblastoma presenting with cutaneous blanching nodules. J Am Acad Dermatol. 1982, 6: 389-391. 10.1016/S0190-9622(82)70034-9.CrossRefPubMed
8.
go back to reference Spix C, Berthold F, Erttmann R, Fehse N, Hero B, Klein G, Sander J, Schwarz K, Treuner J, Zorn U, Michaellis J: Neuroblastoma screening at one year of age. N Engl J Med. 2002, 346: 1047-1053. 10.1056/NEJMoa012277.CrossRefPubMed Spix C, Berthold F, Erttmann R, Fehse N, Hero B, Klein G, Sander J, Schwarz K, Treuner J, Zorn U, Michaellis J: Neuroblastoma screening at one year of age. N Engl J Med. 2002, 346: 1047-1053. 10.1056/NEJMoa012277.CrossRefPubMed
9.
go back to reference Milović I, Sćekić M, Vujić D, Djurisić S, Djokić D: The characteristics of mediastinal neuroblastoma and perspectives on surgical excision. Acta ChirIugosl. 2003, 50: 103-107. Milović I, Sćekić M, Vujić D, Djurisić S, Djokić D: The characteristics of mediastinal neuroblastoma and perspectives on surgical excision. Acta ChirIugosl. 2003, 50: 103-107.
10.
go back to reference Nitschke R, Smith EI, Shochat S, Altshuler G, Travers H, Shuster JJ, Hayes FA, Patterson R, McWilliams N: Localized neuroblastoma treated by surgery: a Pediatric Oncology Group Study. J Clin Oncol. 1988, 6: 1271-1279.PubMed Nitschke R, Smith EI, Shochat S, Altshuler G, Travers H, Shuster JJ, Hayes FA, Patterson R, McWilliams N: Localized neuroblastoma treated by surgery: a Pediatric Oncology Group Study. J Clin Oncol. 1988, 6: 1271-1279.PubMed
11.
go back to reference Molenaar WM, Baker DL, Pleasure D, Lee VM, Trojanowski JQ: The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Am J Pathol. 1990, 136: 375-382.PubMedPubMedCentral Molenaar WM, Baker DL, Pleasure D, Lee VM, Trojanowski JQ: The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Am J Pathol. 1990, 136: 375-382.PubMedPubMedCentral
12.
go back to reference Aoyama C, Qualman SJ, Regan M, Shimada H: Histopathologic features of composite ganglioneuroblastoma. Immunohistochemical distinction of the stromal component is related to prognosis. Cancer. 1990, 65: 255-264. 10.1002/1097-0142(19900115)65:2<255::AID-CNCR2820650213>3.0.CO;2-5.CrossRefPubMed Aoyama C, Qualman SJ, Regan M, Shimada H: Histopathologic features of composite ganglioneuroblastoma. Immunohistochemical distinction of the stromal component is related to prognosis. Cancer. 1990, 65: 255-264. 10.1002/1097-0142(19900115)65:2<255::AID-CNCR2820650213>3.0.CO;2-5.CrossRefPubMed
13.
go back to reference Hsiao CC, Huang CC, Sheen JM, Tai MH, Chen CM, Huang LL, Chuang JH: Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Mod Pathol. 2005, 18: 656-662. 10.1038/modpathol.3800335.CrossRefPubMed Hsiao CC, Huang CC, Sheen JM, Tai MH, Chen CM, Huang LL, Chuang JH: Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. Mod Pathol. 2005, 18: 656-662. 10.1038/modpathol.3800335.CrossRefPubMed
Metadata
Title
Ganglioneuroblastoma of the posterior mediastinum: a case report
Authors
Saulat H Fatimi
Samira A Bawany
Awais Ashfaq
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-5-322

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