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Open Access 01-12-2010 | Case report

Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report

Authors: Vassilios J Papantoniou, Evangelia K Sotiropoulou, Pipitsa N Valsamaki, Angeliki G Tsaroucha, Maria G Sotiropoulou, Nikolaos D Ptohis, Aikaterini J Stipsanelli, Konstantinos E Dimitrakakis, Spyridon G Marinopoulos, Spyridon T Tsiouris, Aris J Antsaklis

Published in: Journal of Medical Case Reports | Issue 1/2010

Abstract

Introduction

Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.

Case presentation

We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.

Conclusion

In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.

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Papantoniou V, Sotiropoulou E, Tsiouris S, Ptohis N, Sotiropoulou M, Tsigris A, Stipsanelli A, Sirgiannis K, Dimitrakakis K, Valsamaki P, Kounadi E, Makris N, Zerva C, Antsaklis A: Correlation of mammographic density with the mode of scintimammographic ^{99 m}Tc-(V)DMSA uptake in various breast pathologies [abstract]. EJNMMI. 2007, 34: s306-

Title: Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report
Authors: Vassilios J Papantoniou
Evangelia K Sotiropoulou
Pipitsa N Valsamaki
Angeliki G Tsaroucha
Maria G Sotiropoulou
Nikolaos D Ptohis
Aikaterini J Stipsanelli
Konstantinos E Dimitrakakis
Spyridon G Marinopoulos
Spyridon T Tsiouris
Aris J Antsaklis
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-4-89

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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