Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Giant renal oncocytoma: a case report and review of the literature

Authors: Sami Akbulut, Ayhan Senol, Bahri Cakabay, Arsenal Sezgin

Published in: Journal of Medical Case Reports | Issue 1/2010

Login to get access

Abstract

Introduction

Renal oncocytomas are benign neoplasms derived from cells of the distal renal tubule, and comprise 5% to 7% of primary renal neoplasms. Oncocytomas are mostly asymptomatic, and the majority of tumors are discovered incidentally. In this case report, we present a case of a patient with a giant oncocytoma arising from her left kidney.

Case presentation

We describe a 25-year-old Turkish woman who was admitted to our hospital with abdominal pain and a 3-year palpable abdominal mass, which was found present since her second pregnancy. Examination revealed a 15 × 20-cm mass in her abdominal cavity. Computed tomography revealed a mass with regular outlines, measuring 18 × 11 × 12 cm, associated with the left kidney, and causing marked hydroureteronephrosis. We excised the mass and performed a left nephrectomy on our patient. The immunohistopathology of the mass was consistent with renal oncocytoma. No local or distant metastasis was seen at 6 months postoperatively.

Conclusion

To the best of our knowledge, this is the second largest renal oncocytoma described in the English language literature. This is also the first reported giant oncocytoma that presented during pregnancy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Amin MB, Crotty TB, Tickoo SK, Farrow GM: Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol. 1997, 21 (1): 1-12. 10.1097/00000478-199701000-00001.CrossRefPubMed Amin MB, Crotty TB, Tickoo SK, Farrow GM: Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol. 1997, 21 (1): 1-12. 10.1097/00000478-199701000-00001.CrossRefPubMed
2.
go back to reference Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, Reuter VE: Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol. 1997, 21 (8): 871-883. 10.1097/00000478-199708000-00001.CrossRefPubMed Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, Reuter VE: Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol. 1997, 21 (8): 871-883. 10.1097/00000478-199708000-00001.CrossRefPubMed
3.
go back to reference Radopoulos D, Tzakas K, Tahmatzopoulos A: A rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol. 2006, 6: 26-10.1186/1471-2490-6-26.CrossRefPubMedPubMedCentral Radopoulos D, Tzakas K, Tahmatzopoulos A: A rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol. 2006, 6: 26-10.1186/1471-2490-6-26.CrossRefPubMedPubMedCentral
4.
go back to reference Demos TC, Malone AJ: Computed tomography of a giant renal oncocytoma. J Comp Assist Tomogr. 1988, 12 (5): 899-900. Demos TC, Malone AJ: Computed tomography of a giant renal oncocytoma. J Comp Assist Tomogr. 1988, 12 (5): 899-900.
5.
go back to reference Sundararajan S, Dyer J, Pemberton R, Cohen RJ: Asymptomatic giant renal oncocytoma presenting with hypertension. Pathol. 2008, 40 (7): 723-724. 10.1080/00313020802436865.CrossRef Sundararajan S, Dyer J, Pemberton R, Cohen RJ: Asymptomatic giant renal oncocytoma presenting with hypertension. Pathol. 2008, 40 (7): 723-724. 10.1080/00313020802436865.CrossRef
6.
go back to reference Banks KL, Cherullo EE, Novick AC: Giant renal oncocytoma. Urol. 2001, 57 (2): 365-366. 10.1016/S0090-4295(00)00913-4.CrossRefPubMed Banks KL, Cherullo EE, Novick AC: Giant renal oncocytoma. Urol. 2001, 57 (2): 365-366. 10.1016/S0090-4295(00)00913-4.CrossRefPubMed
7.
go back to reference Kiliç S, Altinok MT, Ipek D, Ergin H: Case report of a giant renal oncocytoma. Int Urol Nephrol. 2003, 35 (1): 83-84. 10.1023/A:1025901807469.CrossRefPubMed Kiliç S, Altinok MT, Ipek D, Ergin H: Case report of a giant renal oncocytoma. Int Urol Nephrol. 2003, 35 (1): 83-84. 10.1023/A:1025901807469.CrossRefPubMed
8.
go back to reference Lieber MM: Renal oncocytoma: prognosis and treatment. Eur Urol. 1990, 18 (2): 17-21.PubMed Lieber MM: Renal oncocytoma: prognosis and treatment. Eur Urol. 1990, 18 (2): 17-21.PubMed
9.
go back to reference Zerban H, Nogueira E, Riedasch G, Bannasch P: Renal oncocytoma: origin from the collecting duct. Virchows Arch B Cell Pathol Incl Mol Pathol. 1987, 52 (5): 375-387.PubMed Zerban H, Nogueira E, Riedasch G, Bannasch P: Renal oncocytoma: origin from the collecting duct. Virchows Arch B Cell Pathol Incl Mol Pathol. 1987, 52 (5): 375-387.PubMed
10.
go back to reference Morra MN, Das S: Renal oncocytoma: a review of histogenesis, histopathology, diagnosis and treatment. J Urol. 1993, 150 (2): 295-302.PubMed Morra MN, Das S: Renal oncocytoma: a review of histogenesis, histopathology, diagnosis and treatment. J Urol. 1993, 150 (2): 295-302.PubMed
11.
go back to reference Crotty TB, Farrow GM, Leiber MM: Chromophobe cell renal carcinoma: clinicopathologic feature of 50 cases. J Urol. 1995, 154 (3): 964-967. 10.1016/S0022-5347(01)66944-1.CrossRefPubMed Crotty TB, Farrow GM, Leiber MM: Chromophobe cell renal carcinoma: clinicopathologic feature of 50 cases. J Urol. 1995, 154 (3): 964-967. 10.1016/S0022-5347(01)66944-1.CrossRefPubMed
12.
go back to reference Cochand-Priollet B, Molinié V, Bougaran J, Bouvier R, Dauge-Geffroy MC, Deslignières S, Fournet JC, Gros P, Lesourd A, Saint-André JP, Toublanc M, Vieillefond A, Wassef M, Fontaine A, Groleau L: Renal chromophobe cell carcinoma and oncocytoma: a comparative morphologic, histological and immunohistochemial study of 124 cases. Arch Pathol Lab Med. 1997, 121 (10): 181-186. Cochand-Priollet B, Molinié V, Bougaran J, Bouvier R, Dauge-Geffroy MC, Deslignières S, Fournet JC, Gros P, Lesourd A, Saint-André JP, Toublanc M, Vieillefond A, Wassef M, Fontaine A, Groleau L: Renal chromophobe cell carcinoma and oncocytoma: a comparative morphologic, histological and immunohistochemial study of 124 cases. Arch Pathol Lab Med. 1997, 121 (10): 181-186.
13.
go back to reference Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol. 2009, 40 (2): 206-210. 10.1016/j.humpath.2008.07.002.CrossRefPubMed Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol. 2009, 40 (2): 206-210. 10.1016/j.humpath.2008.07.002.CrossRefPubMed
14.
go back to reference Geramizadeh B, Ravanshad M, Rahsaz M: Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. Indian J Pathol Microbiol. 2008, 51 (2): 167-171. 10.4103/0377-4929.41641.CrossRefPubMed Geramizadeh B, Ravanshad M, Rahsaz M: Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. Indian J Pathol Microbiol. 2008, 51 (2): 167-171. 10.4103/0377-4929.41641.CrossRefPubMed
15.
go back to reference Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, Young A, de Peralta-Venturina M, Amin MB: Distribution of cytokeratins and Vimentin in adult renal neoplasms and normal renal tissue. Am J Surg Pathol. 2005, 29 (6): 747-754. 10.1097/01.pas.0000163362.78475.63.CrossRefPubMed Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, Young A, de Peralta-Venturina M, Amin MB: Distribution of cytokeratins and Vimentin in adult renal neoplasms and normal renal tissue. Am J Surg Pathol. 2005, 29 (6): 747-754. 10.1097/01.pas.0000163362.78475.63.CrossRefPubMed
16.
go back to reference Langer C, Wegscheider BJ, Ratschek M, Schips L, Zigeuner R: Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 223 tumors. Virchows Arch. 2004, 444: 127-134. 10.1007/s00428-003-0948-2.CrossRef Langer C, Wegscheider BJ, Ratschek M, Schips L, Zigeuner R: Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 223 tumors. Virchows Arch. 2004, 444: 127-134. 10.1007/s00428-003-0948-2.CrossRef
17.
go back to reference Shin LK, Badler RL, Bruno FM, Gupta M, Katz DS: Radiology-pathology conference: bilateral renal oncocytomas. Clin Imaging. 2004, 28 (5): 344-348. 10.1016/j.clinimag.2004.04.002.CrossRefPubMed Shin LK, Badler RL, Bruno FM, Gupta M, Katz DS: Radiology-pathology conference: bilateral renal oncocytomas. Clin Imaging. 2004, 28 (5): 344-348. 10.1016/j.clinimag.2004.04.002.CrossRefPubMed
18.
go back to reference Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H: Renal oncocytoma: multifocality, bilateralism, metachronous tumor development, and coexistent renal cell carcinoma. J Urol. 1999, 162 (1): 40-42. 10.1097/00005392-199907000-00010.CrossRefPubMed Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H: Renal oncocytoma: multifocality, bilateralism, metachronous tumor development, and coexistent renal cell carcinoma. J Urol. 1999, 162 (1): 40-42. 10.1097/00005392-199907000-00010.CrossRefPubMed
19.
go back to reference Chao DH, Zisman A, Pantuck AJ, Freedland SJ, Said JW, Belldegrun AS: Changing concepts in the management of renal oncocytoma. Urol. 2002, 59 (5): 635-642. 10.1016/S0090-4295(01)01630-2.CrossRefPubMed Chao DH, Zisman A, Pantuck AJ, Freedland SJ, Said JW, Belldegrun AS: Changing concepts in the management of renal oncocytoma. Urol. 2002, 59 (5): 635-642. 10.1016/S0090-4295(01)01630-2.CrossRefPubMed
20.
go back to reference Neuzillet Y, Lechevallier E, Andre M, Daniel L, Nahon O, Coulange C: Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy. Urol. 2005, 66 (6): 1181-1185. 10.1016/j.urology.2005.06.001.CrossRefPubMed Neuzillet Y, Lechevallier E, Andre M, Daniel L, Nahon O, Coulange C: Follow-up of renal oncocytoma diagnosed by percutaneous tumor biopsy. Urol. 2005, 66 (6): 1181-1185. 10.1016/j.urology.2005.06.001.CrossRefPubMed
Metadata
Title
Giant renal oncocytoma: a case report and review of the literature
Authors
Sami Akbulut
Ayhan Senol
Bahri Cakabay
Arsenal Sezgin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-52

Other articles of this Issue 1/2010

Journal of Medical Case Reports 1/2010 Go to the issue