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Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Low-concentration, continuous brachial plexus block in the management of Purple Glove Syndrome: a case report

Authors: Georgene Singh, Verghese T Cherian, Binu P Thomas

Published in: Journal of Medical Case Reports | Issue 1/2010

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Abstract

Introduction

Purple Glove Syndrome is a devastating complication of intravenous phenytoin administration. Adequate analgesia and preservation of limb movement for physiotherapy are the two essential components of management.

Case presentation

A 26-year-old Tamil woman from India developed Purple Glove Syndrome after intravenous administration of phenytoin. She was managed conservatively by limb elevation, physiotherapy and oral antibiotics. A 20G intravenous cannula was inserted into the sheath of her brachial plexus and a continuous infusion of bupivacaine at a low concentration (0.1%) with fentanyl (2 μg/ml) at a rate of 1 to 2 ml/hr was given. She had adequate analgesia with preserved motor function which helped in physiotherapy and functional recovery of the hand in a month.

Conclusion

A continuous blockade of the brachial plexus with a low concentration of bupivacaine and fentanyl helps to alleviate the vasospasm and the pain while preserving the motor function for the patient to perform active movements of the finger and hand.
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Literature
1.
go back to reference Snelson C, Dieckman B: Recognizing and managing purple glove syndrome. Crit Care Nurse. 2000, 20 (3): 54-61.PubMed Snelson C, Dieckman B: Recognizing and managing purple glove syndrome. Crit Care Nurse. 2000, 20 (3): 54-61.PubMed
2.
go back to reference Bhattacharjee P, Glusac EJ: Early histopathologic changes in purple glove syndrome. J Cutan Pathol. 2004, 31 (7): 513-515. 10.1111/j.0303-6987.2004.00224.x.CrossRefPubMed Bhattacharjee P, Glusac EJ: Early histopathologic changes in purple glove syndrome. J Cutan Pathol. 2004, 31 (7): 513-515. 10.1111/j.0303-6987.2004.00224.x.CrossRefPubMed
3.
go back to reference Edwards JJ, Bosek V: Extravasation injury of the upper extremity by intravenous phenytoin. Anesth Analg. 2002, 94 (3): 672-673. 10.1097/00000539-200203000-00035.CrossRefPubMed Edwards JJ, Bosek V: Extravasation injury of the upper extremity by intravenous phenytoin. Anesth Analg. 2002, 94 (3): 672-673. 10.1097/00000539-200203000-00035.CrossRefPubMed
4.
go back to reference O'Brien TJ, Cascino GD, So EL, Hanna DR: Incidence and clinical consequence of the purple glove syndrome in patients receiving intravenous phenytoin. Neurology. 1998, 51 (4): 1034-1039.CrossRefPubMed O'Brien TJ, Cascino GD, So EL, Hanna DR: Incidence and clinical consequence of the purple glove syndrome in patients receiving intravenous phenytoin. Neurology. 1998, 51 (4): 1034-1039.CrossRefPubMed
5.
go back to reference Righini M, Angellillo-Scherrer A, Gueddi S, Le Gal G, Bounameaux H: Management of severe ischemia of the hand following intra-arterial injection. Thromb Haemost. 2005, 94 (1): 219-221.PubMed Righini M, Angellillo-Scherrer A, Gueddi S, Le Gal G, Bounameaux H: Management of severe ischemia of the hand following intra-arterial injection. Thromb Haemost. 2005, 94 (1): 219-221.PubMed
6.
go back to reference Yoshikawa H, Abe T, Oda Y: Purple glove syndrome caused by oral administration of phenytoin. J Child Neurol. 2000, 15 (11): 762-10.1177/088307380001501110.CrossRefPubMed Yoshikawa H, Abe T, Oda Y: Purple glove syndrome caused by oral administration of phenytoin. J Child Neurol. 2000, 15 (11): 762-10.1177/088307380001501110.CrossRefPubMed
7.
go back to reference Burneo JG, Anandan JV, Barkley GL: A prospective study of the incidence of the purple glove syndrome. Epilepsia. 2001, 42 (9): 1156-1159. 10.1046/j.1528-1157.2001.12901.x.CrossRefPubMed Burneo JG, Anandan JV, Barkley GL: A prospective study of the incidence of the purple glove syndrome. Epilepsia. 2001, 42 (9): 1156-1159. 10.1046/j.1528-1157.2001.12901.x.CrossRefPubMed
8.
go back to reference Spengler RF, Arrowsmith JB, Kilarski DJ, Buchanan C, Von Behren L, Graham DR: Severe soft-tissue injury following intravenous infusion of phenytoin. Patient and drug administration risk factors. Arch Intern Med. 1988, 148 (6): 1329-1333. 10.1001/archinte.148.6.1329.CrossRefPubMed Spengler RF, Arrowsmith JB, Kilarski DJ, Buchanan C, Von Behren L, Graham DR: Severe soft-tissue injury following intravenous infusion of phenytoin. Patient and drug administration risk factors. Arch Intern Med. 1988, 148 (6): 1329-1333. 10.1001/archinte.148.6.1329.CrossRefPubMed
9.
go back to reference Joint Formulary Committee: British National Formulary. London. 1999 Joint Formulary Committee: British National Formulary. London. 1999
10.
go back to reference Breivik H, Cousins MJ, Lofstrom JB: Sympathetic Neural Blockade of Upper and Lower Extremity. Neural Blockade in Clinical Anesthesia and Management of Pain. Edited by: Cousins MJ, Bridenbaugh PO. 1998, Philadelphia: Lippincott, 411-445. 3 Breivik H, Cousins MJ, Lofstrom JB: Sympathetic Neural Blockade of Upper and Lower Extremity. Neural Blockade in Clinical Anesthesia and Management of Pain. Edited by: Cousins MJ, Bridenbaugh PO. 1998, Philadelphia: Lippincott, 411-445. 3
11.
go back to reference Elias M: Cervical sympathetic and stellate ganglion blocks. Pain Physician. 2000, 3 (3): 294-304.PubMed Elias M: Cervical sympathetic and stellate ganglion blocks. Pain Physician. 2000, 3 (3): 294-304.PubMed
12.
go back to reference Strickartz GR: Neural Physiology and local anesthesia action in Neural Blockade in Clinical Anaesthesia and management of pain. Neural Blockade in Clinical Anesthesia and Management of Pain. Edited by: Cousins MJ, Bridenbaugh PO. 1998, Philadelphia: Lippincott, 35-54. 3 Strickartz GR: Neural Physiology and local anesthesia action in Neural Blockade in Clinical Anaesthesia and management of pain. Neural Blockade in Clinical Anesthesia and Management of Pain. Edited by: Cousins MJ, Bridenbaugh PO. 1998, Philadelphia: Lippincott, 35-54. 3
13.
go back to reference Heavner JE, deJong R: Lidocaine blocking concentration for B- and C- nerve fibers. Anesthesiology. 1974, 40: 228-10.1097/00000542-197403000-00004.CrossRefPubMed Heavner JE, deJong R: Lidocaine blocking concentration for B- and C- nerve fibers. Anesthesiology. 1974, 40: 228-10.1097/00000542-197403000-00004.CrossRefPubMed
14.
go back to reference Rosenberg PH, Heinonen E: Differential sensitivity of A and C nerve fibres to long acting amide local anaesthetics. Br J Anaesth. 1983, 55 (2): 163-167. 10.1093/bja/55.2.163.CrossRefPubMed Rosenberg PH, Heinonen E: Differential sensitivity of A and C nerve fibres to long acting amide local anaesthetics. Br J Anaesth. 1983, 55 (2): 163-167. 10.1093/bja/55.2.163.CrossRefPubMed
16.
go back to reference Nishikawa K, Kanaya N, Nakayama M, Igarashi M, Tsunoda K, Namiki A: Fentalyl Improves Analgesia but Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral Mechanism. Anesth Analg. 2000, 91: 384-387. 10.1097/00000539-200008000-00028.PubMed Nishikawa K, Kanaya N, Nakayama M, Igarashi M, Tsunoda K, Namiki A: Fentalyl Improves Analgesia but Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral Mechanism. Anesth Analg. 2000, 91: 384-387. 10.1097/00000539-200008000-00028.PubMed
17.
go back to reference Klein SM, Nielsen KC: Brachial plexus blocks: infusions and other mechanisms to provide prolonged analgesia. Curr Opin Anaesthesiol. 2003, 16 (4): 393-399. 10.1097/00001503-200308000-00005.PubMed Klein SM, Nielsen KC: Brachial plexus blocks: infusions and other mechanisms to provide prolonged analgesia. Curr Opin Anaesthesiol. 2003, 16 (4): 393-399. 10.1097/00001503-200308000-00005.PubMed
18.
go back to reference Mahajan RP, Batra YK, Rajeev S: Intravenous phenytoin and percutaneous arterial cannulation: the purple-glove syndrome. Eur J Anaesthesiol. 2007, 24 (10): 900-901. 10.1017/S0265021507001007.CrossRefPubMed Mahajan RP, Batra YK, Rajeev S: Intravenous phenytoin and percutaneous arterial cannulation: the purple-glove syndrome. Eur J Anaesthesiol. 2007, 24 (10): 900-901. 10.1017/S0265021507001007.CrossRefPubMed
Metadata
Title
Low-concentration, continuous brachial plexus block in the management of Purple Glove Syndrome: a case report
Authors
Georgene Singh
Verghese T Cherian
Binu P Thomas
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-48

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