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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Tamsulosin-induced severe hypotension during general anesthesia: a case report

Authors: Dileep Kumar, Fauzia Anis Khan

Published in: Journal of Medical Case Reports | Issue 1/2010

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Abstract

Introduction

Tamsulosin, a selective α1-adrenergic receptor (α1-AR) antagonist, is a widely prescribed first-line agent for benign prostatic hypertrophy (BPH). Its interaction with anesthetic agents has not been described.

Case presentation

We report the case of 54-year-old Asian man undergoing elective left thyroid lobectomy. The only medication the patient was taking was tamsulosin 0.4 mg for the past year for BPH. He developed persistent hypotension during the maintenance phase of anesthesia while receiving oxygen, nitrous oxide and 1% isoflurane. The hypotension could have been attributable to a possible interaction between inhalational anesthetic and tamsulosin.

Conclusion

Vigilance for unexpected hypotension is important in surgical patients who are treated with selective α1-AR blockers. If hypotension occurs, vasopressors that act directly on adrenergic receptors could be more effective.
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Metadata
Title
Tamsulosin-induced severe hypotension during general anesthesia: a case report
Authors
Dileep Kumar
Fauzia Anis Khan
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-365

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