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Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report

Authors: Christos N Stoidis, Basileios G Spyropoulos, Evangelos P Misiakos, Christos K Fountzilas, Panorea P Paraskeva, Constantine I Fotiadis

Published in: Journal of Medical Case Reports | Issue 1/2010

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Abstract

Introduction

Intra-abdominal fibromatosis, usually located at the mesenteric level, is a locally invasive tumor of fibrous origin, with no ability to metastasize, but a tendency to recur. Certain non-typical cases of intra-abdominal fibromatosis with involvement of the bowel wall can be misdiagnosed because of their different biological behavior.

Case presentation

We describe the case of a 64-year-old Caucasian man presenting with mesenteric fibromatosis and involvement of the bowel wall, who was treated surgically. The macroscopic and microscopic appearance of the lesion mimicked a gastrointestinal stromal tumor, a tumor with potential malignant behavior.

Conclusion

It is essential to make an early and correct diagnosis in such equivocal cases, so that the appropriate treatment can be chosen and suitable patients admitted to clinical trials if appropriate. New and reliable criteria for discriminating between intra-abdominal fibromatosis and gastrointestinal stromal tumor should be proposed and established because novel sophisticated therapeutic strategies have been introduced in the international literature.
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Literature
1.
go back to reference Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol. 2006, 7: 438-43. 10.1007/s11864-006-0019-4.CrossRefPubMed Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol. 2006, 7: 438-43. 10.1007/s11864-006-0019-4.CrossRefPubMed
2.
go back to reference Church J, Lynch C, Neary P, LaGuardia L, Elayi EL: A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. Dis Colon Rectum. 2008, 51: 897-901. 10.1007/s10350-008-9232-5.CrossRefPubMed Church J, Lynch C, Neary P, LaGuardia L, Elayi EL: A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. Dis Colon Rectum. 2008, 51: 897-901. 10.1007/s10350-008-9232-5.CrossRefPubMed
3.
go back to reference Connolly EM, Gaffney E, Reynolds JV: Gastrointestinal stromal tumours. Br J Surg. 2003, 90: 1178-86. 10.1002/bjs.4352.CrossRefPubMed Connolly EM, Gaffney E, Reynolds JV: Gastrointestinal stromal tumours. Br J Surg. 2003, 90: 1178-86. 10.1002/bjs.4352.CrossRefPubMed
4.
go back to reference Al-Nafussi A, Wong NACS: Intra-abdominal spindle cell lesions: a review and practical aids to diagnosis. Histopathol. 2001, 38: 387-402. 10.1046/j.1365-2559.2001.01119.x.CrossRef Al-Nafussi A, Wong NACS: Intra-abdominal spindle cell lesions: a review and practical aids to diagnosis. Histopathol. 2001, 38: 387-402. 10.1046/j.1365-2559.2001.01119.x.CrossRef
5.
go back to reference Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol. 2005, 11: 5226-5228.PubMedPubMedCentral Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M: Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol. 2005, 11: 5226-5228.PubMedPubMedCentral
6.
go back to reference Rodriguez JA, Guarda LA, Rosai J: Mesenteric fibromatosis with involvement of the gastrointestinal tract. A GIST simulator: a study of 25 cases. Am J Clin Pathol. 2004, 121: 93-8. 10.1309/59VAH0KVF53WB633.CrossRefPubMed Rodriguez JA, Guarda LA, Rosai J: Mesenteric fibromatosis with involvement of the gastrointestinal tract. A GIST simulator: a study of 25 cases. Am J Clin Pathol. 2004, 121: 93-8. 10.1309/59VAH0KVF53WB633.CrossRefPubMed
7.
go back to reference Holubar S, Dwivedi AJ, O'Connor J: Giant mesenteric fibromatosis presenting as small bowel obstruction. Am Surg. 2006, 72: 427-9.PubMed Holubar S, Dwivedi AJ, O'Connor J: Giant mesenteric fibromatosis presenting as small bowel obstruction. Am Surg. 2006, 72: 427-9.PubMed
8.
go back to reference Collins D, Myers E, Kavanagh D, Lennon G, McDermott E: Mesenteric desmoid tumor causing ureteric obstruction. International J Urol. 2008, 15: 261-262. 10.1111/j.1442-2042.2007.01981.x.CrossRef Collins D, Myers E, Kavanagh D, Lennon G, McDermott E: Mesenteric desmoid tumor causing ureteric obstruction. International J Urol. 2008, 15: 261-262. 10.1111/j.1442-2042.2007.01981.x.CrossRef
9.
go back to reference Dozois EJ, Dozois RR: Desmoid disease. Mayo Clinic Gastrointestinal Surgery. Edited by: Kelly KA, Sarr MG, Hinder RA. 2004, Saunders Eds: Philadelphia, 563-565. Dozois EJ, Dozois RR: Desmoid disease. Mayo Clinic Gastrointestinal Surgery. Edited by: Kelly KA, Sarr MG, Hinder RA. 2004, Saunders Eds: Philadelphia, 563-565.
11.
go back to reference Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin N Amer. 2005, 19: 565-71. 10.1016/j.hoc.2005.03.008.CrossRef Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin N Amer. 2005, 19: 565-71. 10.1016/j.hoc.2005.03.008.CrossRef
12.
go back to reference Latchford AR, Sturt NJH, Neale K, Rogers PA, Phillips RK: A ten-year-review of surgery for desmoid disease associated with familial adenomatous polyposis. Br J Surg. 2006, 93: 1258-64. 10.1002/bjs.5425.CrossRefPubMed Latchford AR, Sturt NJH, Neale K, Rogers PA, Phillips RK: A ten-year-review of surgery for desmoid disease associated with familial adenomatous polyposis. Br J Surg. 2006, 93: 1258-64. 10.1002/bjs.5425.CrossRefPubMed
13.
go back to reference Rampone B, Pedrazzani C, Marrelli D, Pinto E, Roviello F: Updates on abdominal desmoid tumors. World J Gastroenterol. 2007, 13: 5985-5988. 10.3748/wjg.13.5985.CrossRefPubMedPubMedCentral Rampone B, Pedrazzani C, Marrelli D, Pinto E, Roviello F: Updates on abdominal desmoid tumors. World J Gastroenterol. 2007, 13: 5985-5988. 10.3748/wjg.13.5985.CrossRefPubMedPubMedCentral
14.
go back to reference Melis M, Zager JS, Sondak VK: Multimodality management of desmoid tumors: how important is a negative surgical margin?. J Surg Oncol. 2008, 98: 594-602. 10.1002/jso.21033.CrossRefPubMed Melis M, Zager JS, Sondak VK: Multimodality management of desmoid tumors: how important is a negative surgical margin?. J Surg Oncol. 2008, 98: 594-602. 10.1002/jso.21033.CrossRefPubMed
15.
go back to reference Sturt JNH, Clark SK: Current ideas in desmoid tumors. Familial Cancer. 2006, 5: 275-85. 10.1007/s10689-005-5675-1.CrossRefPubMed Sturt JNH, Clark SK: Current ideas in desmoid tumors. Familial Cancer. 2006, 5: 275-85. 10.1007/s10689-005-5675-1.CrossRefPubMed
16.
go back to reference Tamura K, Tani M, Kinoshita H, Yamaye H: Mesenteric desmoids tumor of the interposed jejunal pouch after total gastrectomy. World J Surg Oncol. 2006, 4: 27-31. 10.1186/1477-7819-4-27.CrossRefPubMedPubMedCentral Tamura K, Tani M, Kinoshita H, Yamaye H: Mesenteric desmoids tumor of the interposed jejunal pouch after total gastrectomy. World J Surg Oncol. 2006, 4: 27-31. 10.1186/1477-7819-4-27.CrossRefPubMedPubMedCentral
17.
go back to reference Chatzipetrou MA, Tzakis AG, Pinna AD, Kato T, Misiakos EP, Tsaroucha AK, Weppler D, Ruiz P, Berho M, Fishbein T, Conn HO, Ricordi C: Intestinal transplantation for the treatment of desmoid tumors associated with familial adenomatous polyposis. Surgery. 2001, 129: 277-81. 10.1067/msy.2001.110770.CrossRefPubMed Chatzipetrou MA, Tzakis AG, Pinna AD, Kato T, Misiakos EP, Tsaroucha AK, Weppler D, Ruiz P, Berho M, Fishbein T, Conn HO, Ricordi C: Intestinal transplantation for the treatment of desmoid tumors associated with familial adenomatous polyposis. Surgery. 2001, 129: 277-81. 10.1067/msy.2001.110770.CrossRefPubMed
18.
go back to reference Sakorafas GH, Nissotakis C, Peros G: Abdominal desmoid tumors. Surg Oncol. 2007, 16: 131-142. 10.1016/j.suronc.2007.07.009.CrossRefPubMed Sakorafas GH, Nissotakis C, Peros G: Abdominal desmoid tumors. Surg Oncol. 2007, 16: 131-142. 10.1016/j.suronc.2007.07.009.CrossRefPubMed
19.
go back to reference Yantiss RK, Spiro IJ, Compton CC, Rosemberg AE: Gastrointestinal stromal tumor versus intra-abdominal fibromatosis of the bowel wall. Am J Surg Pathol. 2000, 24: 947-957. 10.1097/00000478-200007000-00006.CrossRefPubMed Yantiss RK, Spiro IJ, Compton CC, Rosemberg AE: Gastrointestinal stromal tumor versus intra-abdominal fibromatosis of the bowel wall. Am J Surg Pathol. 2000, 24: 947-957. 10.1097/00000478-200007000-00006.CrossRefPubMed
20.
go back to reference Mace J, Biermann JS, Sondak V: Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. Cancer. 2002, 11: 2373-2379. 10.1002/cncr.11029.CrossRef Mace J, Biermann JS, Sondak V: Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. Cancer. 2002, 11: 2373-2379. 10.1002/cncr.11029.CrossRef
Metadata
Title
Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report
Authors
Christos N Stoidis
Basileios G Spyropoulos
Evangelos P Misiakos
Christos K Fountzilas
Panorea P Paraskeva
Constantine I Fotiadis
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-314

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