Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Cyclosporine-A therapy-induced multiple bilateral breast and accessory axillary breast fibroadenomas: a case report

Authors: Ahmed Darwish, Ayman O Nasr, Lamya A El Hassan, Ahmed H Fahal

Published in: Journal of Medical Case Reports | Issue 1/2010

Login to get access

Abstract

Introduction

Breast adenoma is common. However, in the setting of post-transplantation immune suppression it may be expressed differently.

Case presentation

A 35-year-old Sudanese woman, with a history of renal transplantation two and half years prior to presentation, was on a single immune suppression therapy in the form of cyclosporine-A since the transplantation. During a regular follow-up visit, she was noticed to have gingival hypertrophy and bilateral breast and axillary swellings. She underwent successful surgical resection of the bilateral fibroadenomas.

Conclusions

Cyclosporine-A therapy post renal transplantation is associated with an increased incidence of benign breast changes as fibroadenoma. Regular follow-up and appropriate selection of immunosuppressant therapy are essential in the post transplantation management of these patients.
Appendix
Available only for authorised users
Literature
1.
go back to reference Muttarak M, Peh WC, Chaiwun B, Lumlertgul D: Multiple bilateral giant fibroadenomas associated with cyclosporine A therapy in a renal transplant recipient. Australas Radiol. 2001, 45 (4): 517-519. 10.1046/j.1440-1673.2001.00970.x.CrossRefPubMed Muttarak M, Peh WC, Chaiwun B, Lumlertgul D: Multiple bilateral giant fibroadenomas associated with cyclosporine A therapy in a renal transplant recipient. Australas Radiol. 2001, 45 (4): 517-519. 10.1046/j.1440-1673.2001.00970.x.CrossRefPubMed
2.
go back to reference Weinstein SP, Orel SG, Collazzo L, Conant EF, Lawton TJ, Czerniecki B: Cyclosporin A-induced fibroadenomas of the breast: report of five cases. Radiology. 2001, 220 (2): 465-468.CrossRefPubMed Weinstein SP, Orel SG, Collazzo L, Conant EF, Lawton TJ, Czerniecki B: Cyclosporin A-induced fibroadenomas of the breast: report of five cases. Radiology. 2001, 220 (2): 465-468.CrossRefPubMed
3.
go back to reference Cyrlak D, Pahl M, Carpenter SE: Breast imaging case of the day. Multiple giant fibroadenomas associated with cyclosporin A therapy. Radiographics. 1999, 19 (2): 549-551.CrossRefPubMed Cyrlak D, Pahl M, Carpenter SE: Breast imaging case of the day. Multiple giant fibroadenomas associated with cyclosporin A therapy. Radiographics. 1999, 19 (2): 549-551.CrossRefPubMed
4.
go back to reference Campbell A, Moazami N, Ditkoff BA, Kurtz E, Estabrook A, Schnabel F: Short-term outcome of chronic immunosuppression on the development of breast lesions in premenopausal heart and lung transplant patients. J Surg Res. 1998, 78 (1): 27-30. 10.1006/jsre.1998.5414.CrossRefPubMed Campbell A, Moazami N, Ditkoff BA, Kurtz E, Estabrook A, Schnabel F: Short-term outcome of chronic immunosuppression on the development of breast lesions in premenopausal heart and lung transplant patients. J Surg Res. 1998, 78 (1): 27-30. 10.1006/jsre.1998.5414.CrossRefPubMed
5.
go back to reference Son EJ, Oh KK, Kim EK, Cho N, Lee JD, Kim SH: Characteristic imaging features of breast fibroadenomas in women given cyclosporin A after renal transplantation. J Clin Ultrasound. 2004, 32 (2): 69-77. 10.1002/jcu.10233.CrossRefPubMed Son EJ, Oh KK, Kim EK, Cho N, Lee JD, Kim SH: Characteristic imaging features of breast fibroadenomas in women given cyclosporin A after renal transplantation. J Clin Ultrasound. 2004, 32 (2): 69-77. 10.1002/jcu.10233.CrossRefPubMed
6.
go back to reference Kanaan N, Goffin E: Multiple bilateral fibroadenomas of the breasts requiring mastectomy in a renal transplant patient. Clin Nephrol. 2004, 61 (2): 151-154.CrossRefPubMed Kanaan N, Goffin E: Multiple bilateral fibroadenomas of the breasts requiring mastectomy in a renal transplant patient. Clin Nephrol. 2004, 61 (2): 151-154.CrossRefPubMed
Metadata
Title
Cyclosporine-A therapy-induced multiple bilateral breast and accessory axillary breast fibroadenomas: a case report
Authors
Ahmed Darwish
Ayman O Nasr
Lamya A El Hassan
Ahmed H Fahal
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-267

Other articles of this Issue 1/2010

Journal of Medical Case Reports 1/2010 Go to the issue