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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report

Authors: Kumiko Tamaki, Michiro Otaka, Naoto Sakamoto, Kenshi Matsumoto, Shunhei Yamashina, Sumio Watanabe

Published in: Journal of Medical Case Reports | Issue 1/2010

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Abstract

Introduction

Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by leukoerythroblastosis, massive splenomegaly, and increases in the reticular and collagen fibers in the bone marrow. Portal hypertension is observed in some patients with idiopathic myelofibrosis. Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis.

Case presentation

We report a case of a Japanese 63-year-old woman with myelofibrosis and variceal hemorrhage, with a background of concomitant portal and pulmonary hypertension. She was successfully treated through a combination of endoscopic variceal ligation and chemotherapy.

Conclusion

This is the first known report on the successful application of endoscopic variceal ligation and chemotherapy as the therapeutic procedure for an esophageal variceal hemorrhage in a patient with myelofibrosis.
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Literature
1.
Ward HP, Block MH: The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine. 1971, 50: 357-420. 10.1097/00005792-197109000-00001.CrossRefPubMed
2.
Nkai GS, Craddock CG, Figueroa WG: Agnogenic myeloid metaplasia: a survey of 29 cases and a review of the literature. Ann Intern Med. 1962, 57: 419-440.CrossRef
3.
Sullvian A, Rheinlander H, Weintraub LR: Esophageal varices in agnogenic myeloid metaplasia: disappearance after splenectomy. Gastroenterol. 1974, 66: 429-432.
4.
Dagradi AE, Siemsen J, Brook J, Stempien SJ: Bleeding esophageal varices in myelofibrosis. Am J Gastroenterol. 1965, 44: 536-544.PubMed
5.
Roux D, Merlio JP, Quinton A, Balabaud Lamouliatte, Bioulac-Sage P: Agnogenic myeloid metaplasia, portal hypertension, and sinusoidal abnormalities. Gastroenterol. 1987, 92: 1067-1072.
6.
Takasaki M, Takahashi I, Takamatsu M, Yorimitsu S, Yorimitsu Y, Takeda I, Horimi T: Endoscopic injection sclerotherapy for esophageal variceal hemorrhage in a patient with idiopathic myelofibrosis. J Gastroenterol. 1996, 31: 260-262. 10.1007/BF02389527.CrossRefPubMed
7.
Doki N, Irisawa H, Takada S, Sakura T, Miyawaki S: Transjugular intrahepatic portosystemic shunt for the treatment of portal hypertension due to idiopathic myelofibrosis. Intern Med. 2007, 46: 187-190. 10.2169/internalmedicine.46.1768.CrossRefPubMed
8.
Belohlavek J, Schwarz J, Jirasek A, Krajina A, Polak F, Hruby M: Idiopathic myelofibrosis complicated by portal hypertension treated with a transjugular intrahepatic portosystemic shunt (TIPS). Wein Klin Wochenschr. 2001, 113: 208-211.
9.
Tsao MS: Hepatic sinusoidal fibrosis in agnogenic myeloid metaplasia. Am J Clin Pathol. 1989, 91: 302-305.CrossRefPubMed
10.
Wanless IR, Peterson P, Das A, Boinott JK, Moore GW, Bernier V: Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. Hepatol. 1990, 12: 1166-1174. 10.1002/hep.1840120515.CrossRef
11.
Hou MC, Lin HC, Kuo BIT, Chen CH, Lee FY, Lee SD: Comparison of endoscopic variceal injunction sclerotherapy and ligation for the treatment of esophageal variceal hemorrhage: a prospective randomized trial. Hepatol. 1995, 21: 1517-1522.
Metadata
Title
Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report
Authors
Kumiko Tamaki
Michiro Otaka
Naoto Sakamoto
Kenshi Matsumoto
Shunhei Yamashina
Sumio Watanabe
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-25

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