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Open Access 01-12-2008 | Case report

Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report

Authors: Atsushi Nakajima, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Shoji Yamanaka

Published in: Journal of Medical Case Reports | Issue 1/2008

Abstract

Introduction

The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare.

Case presentation

A 63-year-old man was admitted to our hospital with body weight loss (-10 kg during months) and upper abdominal pain from 3 weeks. Abdominal computed tomography demonstrated a pancreatic tumor 10 cm in size and multiple low-density areas in the liver. On admission, the peripheral leukocyte count was elevated to 91,500/mm³ and the serum concentration of granulocyte-colony stimulating factor was 134 pg/mL (normal, < 18.1 pg/mL). Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma. Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor. The patient developed interstitial pneumonia, probably caused by granulocyte-colony stimulating factor, and died 11 days after admission.

Conclusion

This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry.

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Title: Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report
Authors: Atsushi Nakajima
Hirokazu Takahashi
Masahiko Inamori
Yasunobu Abe
Noritoshi Kobayashi
Kensuke Kubota
Shoji Yamanaka
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2008
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-2-391

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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