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Published in: Journal of Medical Case Reports 1/2008

Open Access 01-12-2008 | Case report

Sebaceous carcinoma of the skin of the breast: a case report

Authors: Ahmed Alzaraa, Imran Ghafoor, Andrew Yates, Alhad Dhebri

Published in: Journal of Medical Case Reports | Issue 1/2008

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Abstract

Introduction

Sebaceous gland tumours are rare and their presence should be considered as a marker for Muir-Torre Syndrome, alerting to search for an occult malignancy.

Case presentation

A 43-year-old Caucasian female patient underwent excision of a sebaceous cyst. Histopathology confirmed a sebaceous carcinoma. Further investigations revealed multiple intra-abdominal malignancies. She has been under regular follow-up in the relevant clinics.

Conclusion

Sebaceous carcinoma should be excised completely and followed-up for the detection of possible metastases. Surgical removal of primary or metastatic cancers may be curative and should be attempted wherever possible. It is very important for clinicians not to miss such skin lesions as they may precede the presentation of internal malignancies.
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Literature
1.
go back to reference Tsalis K, Blouhos K, Vasiliadis K, Tsachalis T, Angelopoulos S, Betsis D: Sebaceous gland tumours and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature. World J Surg Oncol. 2006, 4: 8-10.1186/1477-7819-4-8.CrossRefPubMedPubMedCentral Tsalis K, Blouhos K, Vasiliadis K, Tsachalis T, Angelopoulos S, Betsis D: Sebaceous gland tumours and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature. World J Surg Oncol. 2006, 4: 8-10.1186/1477-7819-4-8.CrossRefPubMedPubMedCentral
2.
go back to reference Pettey A, Walsh J: Muir-Torre syndrome: a case report and review of the literature. Cutis. 2005, 75: 149-155.PubMed Pettey A, Walsh J: Muir-Torre syndrome: a case report and review of the literature. Cutis. 2005, 75: 149-155.PubMed
3.
go back to reference Muir E, Bell A, Barlow K: Multiple primary carcinomata of the colon, duodenum and larynx associated with kerato-acanthoma of the face. Br J Surg. 1967, 54: 191-195. 10.1002/bjs.1800540309.CrossRefPubMed Muir E, Bell A, Barlow K: Multiple primary carcinomata of the colon, duodenum and larynx associated with kerato-acanthoma of the face. Br J Surg. 1967, 54: 191-195. 10.1002/bjs.1800540309.CrossRefPubMed
4.
5.
go back to reference Akhtar S, Oza K, Khan S, Wright J: Muir-Torre syndrome: case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature. J Am Acad Dermatol. 1999, 41: 681-686. 10.1016/S0190-9622(99)70001-0.CrossRefPubMed Akhtar S, Oza K, Khan S, Wright J: Muir-Torre syndrome: case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature. J Am Acad Dermatol. 1999, 41: 681-686. 10.1016/S0190-9622(99)70001-0.CrossRefPubMed
6.
go back to reference Coldron J, Reid I: Muir-Torre syndrome. J R Coll Surg Edinb. 2001, 46: 178-9.PubMed Coldron J, Reid I: Muir-Torre syndrome. J R Coll Surg Edinb. 2001, 46: 178-9.PubMed
7.
go back to reference Suspiro A, Fidalgo P, Cravo M, Albuquerque C, Ramalho E, Leitao CN, Costa Mira F: The Muir Torre syndrome: a rare variant of hereditary non-polyposis colorectal cancer associated with hMSH2 mutation. Am J Gastroenterol. 1998, 93: 1572-1574. 10.1111/j.1572-0241.1998.00487.x.CrossRefPubMed Suspiro A, Fidalgo P, Cravo M, Albuquerque C, Ramalho E, Leitao CN, Costa Mira F: The Muir Torre syndrome: a rare variant of hereditary non-polyposis colorectal cancer associated with hMSH2 mutation. Am J Gastroenterol. 1998, 93: 1572-1574. 10.1111/j.1572-0241.1998.00487.x.CrossRefPubMed
8.
go back to reference Curry M, Eng W, Lund K, Paek D, Cockerell CJ: Muir-Torre syndrome: role of the dermatopathologist in diagnosis. Am J Dermatopathol. 2004, 26: 217-221. 10.1097/00000372-200406000-00009.CrossRefPubMed Curry M, Eng W, Lund K, Paek D, Cockerell CJ: Muir-Torre syndrome: role of the dermatopathologist in diagnosis. Am J Dermatopathol. 2004, 26: 217-221. 10.1097/00000372-200406000-00009.CrossRefPubMed
9.
go back to reference Cohen P, Kohn S, Davis D, Kurzrock R: Muir-Torre syndrome. Dermatol Clin. 1995, 13: 79-89.PubMed Cohen P, Kohn S, Davis D, Kurzrock R: Muir-Torre syndrome. Dermatol Clin. 1995, 13: 79-89.PubMed
10.
go back to reference Schwartz R, Torre D: The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol. 1995, 33: 90-104. 10.1016/0190-9622(95)90017-9.CrossRefPubMed Schwartz R, Torre D: The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol. 1995, 33: 90-104. 10.1016/0190-9622(95)90017-9.CrossRefPubMed
11.
go back to reference Cohen P, Kohn S, Kurzrock R: Association of sebaceous gland tumours and internal malignancy: the Muir-Torre syndrome. Am J Med. 1991, 90: 606-613.CrossRefPubMed Cohen P, Kohn S, Kurzrock R: Association of sebaceous gland tumours and internal malignancy: the Muir-Torre syndrome. Am J Med. 1991, 90: 606-613.CrossRefPubMed
12.
go back to reference Chen C, Loweinstein L, James C, Huilgol SC, Selva D: Muir-Torre syndrome and early detection of internal malignancy. Med J Aust. 2003, 178: 368-PubMed Chen C, Loweinstein L, James C, Huilgol SC, Selva D: Muir-Torre syndrome and early detection of internal malignancy. Med J Aust. 2003, 178: 368-PubMed
13.
go back to reference Mangold E, Pegenstecher C, Leister M, Mathiak M, Rutten A, Friedl W, Propping P, Ruzika T, Kruse R: A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome. Med Genet. 2004, 41: 567-572. 10.1136/jmg.2003.012997.CrossRef Mangold E, Pegenstecher C, Leister M, Mathiak M, Rutten A, Friedl W, Propping P, Ruzika T, Kruse R: A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome. Med Genet. 2004, 41: 567-572. 10.1136/jmg.2003.012997.CrossRef
14.
go back to reference Ponti G, Losi L, Di Gregorio C, Roncucci L, Pedroni M, Scarselli A, Benatti P, Seidenari S, Pellacani G, Lembo L, Rossi G, Marino M, Lucci-Cordisco E, Ponz de Leon M: Identification of Muir-Torre syndrome among patients with sebaceous tumours and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry. Cancer. 2005, 103: 1018-1025. 10.1002/cncr.20873.CrossRefPubMed Ponti G, Losi L, Di Gregorio C, Roncucci L, Pedroni M, Scarselli A, Benatti P, Seidenari S, Pellacani G, Lembo L, Rossi G, Marino M, Lucci-Cordisco E, Ponz de Leon M: Identification of Muir-Torre syndrome among patients with sebaceous tumours and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry. Cancer. 2005, 103: 1018-1025. 10.1002/cncr.20873.CrossRefPubMed
15.
go back to reference Fiorentino D, Nguyen J, Egbert B, Swetter SM: Muir-Torre syndrome: confirmation of diagnosis by immunohistochemical analysis of cutaneous lesions. J Am Acad Dermatol. 2004, 50: 476-478. 10.1016/j.jaad.2003.07.027.CrossRefPubMed Fiorentino D, Nguyen J, Egbert B, Swetter SM: Muir-Torre syndrome: confirmation of diagnosis by immunohistochemical analysis of cutaneous lesions. J Am Acad Dermatol. 2004, 50: 476-478. 10.1016/j.jaad.2003.07.027.CrossRefPubMed
Metadata
Title
Sebaceous carcinoma of the skin of the breast: a case report
Authors
Ahmed Alzaraa
Imran Ghafoor
Andrew Yates
Alhad Dhebri
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2008
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-2-276

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