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Journal of Medical Case Reports

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Open Access 01-12-2007 | Case report

Ventricular tachycardia after administration of sildenafil citrate: a case report

Authors: Jeppe G Rasmussen, Egon Toft, Ole Frøbert

Published in: Journal of Medical Case Reports | Issue 1/2007

Abstract

Background

It has not previously been reported that sildenafil citrate causes malignant arrhythmias in humans.

Case presentation

A 41-year-old man developed sustained ventricular tachycardia following sildenafil citrate administration.

Conclusion

It cannot be dismissed that this patient experienced ventricular tachycardia as an adverse effect of sildenafil citrate administration.

Available only for authorised users

Food and Drug Administration: Postmarketing safety of sildenafil citrate (Viagra). Summary of reports of death in Viagra users received from marketing (late March) through mid-November 1998. http://www.fda.gov/cder/consumerinfo/viagra/safety3.htm

Geelen P, Drolet B, Rail J, Bérubé J, Daleau P, Rousseau G, Cardinal R, O'Hara GE, Turgeon J: Sildenafil (Viagra) Prolongs Cardiac Repolarization by Blocking the Rapid Component of the Delayed Rectifier Potassium Current. Circulation. 2000, 102: 275-277.CrossRefPubMed

Ilson BE, Shaddinger BC, Dabiri GA, Patel BR, Boyle DA, Sethuraman V, Montague T, Morganroth J: A definitive study of the effects of PDE-5 inhibitors on cardiac repolarization in middle-age males. Journal of Clinical Pharmacology & Therapeutics. 2004, 75: 47-CrossRef

Swissa M, Ohara T, Lee MH, Kaul S, Shah PK, Hayashi H, Chen PS, Karagueuzian HS: Sildenafil-nitric oxide donor combination promotes ventricular tachyarrhythmias in the swine right ventricle. American Journal of Physiology-Heart and Circulatory Physiology. 2002, 282 (5): H1787-H1792.CrossRefPubMed

Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA: Oral Sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine. 1998, 338: 1397-1404. 10.1056/NEJM199805143382001.CrossRefPubMed

Title: Ventricular tachycardia after administration of sildenafil citrate: a case report
Authors: Jeppe G Rasmussen
Egon Toft
Ole Frøbert
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2007
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-1-65

At a glance: The STEP trials

Springer Medicine

Ventricular tachycardia after administration of sildenafil citrate: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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