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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2007

Open Access 01-12-2007 | Case report

Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report

Authors: Adrian F. Peall, Aidan Hodges

Published in: Journal of Medical Case Reports | Issue 1/2007

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Abstract

Background

Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin is a rare but serious complication of the use of Nitrofurantoin.

Case presentation

A 72 year old woman taking Nitrofurantoin for recurrent urinary sepsis presenting with breathlessness abdominal discomfort and abnormal liver function tests is described. Drug toxicity secondary to Nitrofurantoin was diagnosed. Cessation of the drug and a course of steroids markedly improved her condition.

Discussion

We review the drug reactions associated with Nitrofurantoin and suggest an alternative treatment strategy for recurrent urinary sepsis.

Conclusion

Adverse drug reactions are an important cause of concomitant lung and liver toxicity and the mainstay of treatment is drug withdrawal.
Appendix
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Literature
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Metadata
Title
Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report
Authors
Adrian F. Peall
Aidan Hodges
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2007
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-1-59

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