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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2007

Open Access 01-12-2007 | Case report

Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report

Authors: Ekrem Yeter, Telat Keles, Tahir Durmaz, Engin Bozkurt

Published in: Journal of Medical Case Reports | Issue 1/2007

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Abstract

We describe a patient with previously undiagnosed hypothyroidism who developed rhabdomyolysis while taking a statin. He had no other precipitating factors. The statin was stopped, intravenous fluids were started immediately and L-thyroxin was given after confirming the diagnosis of hypothyroidism. His symptoms improved over a few days. Because rhabdomyolysis is a rare but potentially life threatening disorder when complicated by acute tubular necrosis and renal failure, physicians must pay special attention when starting statins in patients with hyperlipidemia.
Literature
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Tokinaga K, Oeda T, Suziki Y, Matsushima Y: HMG CoA Reductase Inhibitors might ause high elevations of creatine phosphokinase in patients with unnoticed hypothyroidism. Endocrine Journal. 2006, 53: 401-405. 10.1507/endocrj.K04-144.CrossRefPubMed
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Thompson PD, Clarkson P, Karas RH: Statin-associated myopathy. JAMA. 2003, 289: 1681-1690. 10.1001/jama.289.13.1681.CrossRefPubMed
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Larosa JC, He J, Vupputuri S: Effect of statins on risk coronary disease. JAMA. 1999, 282: 2340-2346. 10.1001/jama.282.24.2340.CrossRefPubMed
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Omar MA, Willson JP, Cox TS: Rhabdomyolysis and HMG-COA reductase inhibitors. Ann Pharmacother. 2001, 35: 1096-1107. 10.1345/aph.10228.CrossRefPubMed
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Barahona MJ, Mauri A, Sucuzza N, Paredes R, Wanger AM: Hypothroidism as a cause of Rhabdomyolysis. Endocr J. 2002, 49: 621-623. 10.1507/endocrj.49.621.CrossRefPubMed
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Metadata
Title
Rhabdomyolysis due to the additive effect of statin therapy and hypothyroidism: a case report
Authors
Ekrem Yeter
Telat Keles
Tahir Durmaz
Engin Bozkurt
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2007
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-1-130

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