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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2007

Open Access 01-12-2007 | Case report

The use of nerve growth factor in herpetic keratitis: a case report

Authors: Mauro Cellini, Pietro Leonetti, Emilio C Campos

Published in: Journal of Medical Case Reports | Issue 1/2007

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Abstract

Background

We evaluate the role of nerve growth factor (NGF) eye drops to treat a herpetic corneal ulcer resistant to systemic and local acyclovir treatment in an HIV-positive patient.

Case Presentation

A 68 year old HIV-positive male presented with a herpetic corneal ulcer which was treated unsuccessfully with acyclovir. Acyclovir sensitivity of herpes simplex virus was tested with a dye uptake assay and we found that the herpes simplex virus isolated was resistant to acyclovir. We started eye drop therapy with NGF and the corneal herpetic ulcer healed in 23 treatment days.

Conclusion

The case presented here is the first described in the literature in which a herpetic corneal ulcer was successfully treated with NGF. We recommend that trials of NGF therapy in herpetic keratitis should be carried out on a larger number of acyclovir resistant cases.
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Literature
1.
Shuler J, Engstrom R, Holland G: External ocular disease and anterior segment disorders associated with AIDS. Int Ophthalmol Clin. 1998, 29: 98-104. 10.1097/00004397-198902920-00007.CrossRef
2.
Erlich KS, Mills J, Chatis P: Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1989, 320: 293-296.CrossRefPubMed
3.
Nugler F, Colin JN, Aymard M, Langlois M: Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: report on a two-year sensitivity screening survey. J Med Virol. 1992, 36: 1-12.CrossRef
4.
Kriesel JD: The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitis. DNA and cell biology. 2002, 21: 475-481. 10.1089/10445490260099773.CrossRefPubMed
5.
Bonini S, Lambiase A, Rama P, Caprifoglio G, Aloe L: Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. 2000, 107: 1347-1351. 10.1016/S0161-6420(00)00163-9.CrossRefPubMed
6.
McLaren C, Ellis MN, Hunter GA: A colorimetric assay for the measurement of the sensitivity of herpes simplex viruses to antiviral agents. Antiviral Res. 1983, 3: 223-234. 10.1016/0166-3542(83)90001-3.CrossRefPubMed
7.
Andrei G, Snoeck R, De Clercq E, Esnouf R, Fiten P, Opdenakker G: Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene. J Gen Virol. 2000, 81: 639-648.CrossRefPubMed
8.
Yamamoto M, Sobue G, Yamamoto K: Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res. 1996, 21: 929-938. 10.1007/BF02532343.CrossRefPubMed
9.
Lambiase A, Bonini S, Micera A, Rama P, Bovini S, Aloe L: Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases. Invest Ophthalmol Vis Sci. 1998, 39: 1272-1275.PubMed
10.
Kriesel J, Jones B, Hwang I, Dahms K, Spruance S: Signal transducers and activators of transcription(STATs) are detectable in mouse trigeminal ganglion neurons. J Interferon Cytokine Res. 2001, 21: 445-450. 10.1089/107999001750277934.CrossRefPubMed
Metadata
Title
The use of nerve growth factor in herpetic keratitis: a case report
Authors
Mauro Cellini
Pietro Leonetti
Emilio C Campos
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2007
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-1-124

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