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Annals of Surgical Innovation and Research

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Open Access 01-12-2007 | Case report

Non-invasive MR imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm: a case report

Authors: Simon PS Howarth, Tjun Y Tang, Martin J Graves, Jean-Marie U-King-Im, Zhi-Yong Li, Stewart R Walsh, Michael E Gaunt, Jonathan H Gillard

Published in: Annals of Surgical Innovation and Research | Issue 1/2007

Abstract

Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque.

USPIO-enhanced MRI imaging is a promising non-invasive method to identify high-risk atheromatous plaque inflammation in vivo in humans, in which areas of focal signal loss on MR images have been shown to correspond to the location of activated macrophages, typically at the shoulder regions of the plaque. This is the first report in humans describing simultaneous USPIO uptake within atheroma in two different arterial territories and again emphasises that atherosclerosis is a truly systemic disease. With further work, USPIO-enhanced MR imaging may be useful in identifying inflamed vulnerable atheromatous plaques in vivo, so refining patient selection for intervention and allowing appropriate early aggressive pharmacotherapy to prevent plaque rupture.

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Tang T Howarth, S. P. S., Miller, S. R., Trivedi, R. A., Graves, M. J., U- King-Im, J. M., Li, Z. Y., Brown, A. P., Kirkpatrick, P. J., Gaunt, M. E., Gillard, J. H.: Assessment of Inflammatory Burden Contralateral to the Symptomatic Carotid Stenosis Using High-Resolution Ultrasmall, Superparamagnetic Iron Oxide-Enhanced MRI. Stroke 2006.

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Title: Non-invasive MR imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm: a case report
Authors: Simon PS Howarth
Tjun Y Tang
Martin J Graves
Jean-Marie U-King-Im
Zhi-Yong Li
Stewart R Walsh
Michael E Gaunt
Jonathan H Gillard
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Annals of Surgical Innovation and Research / Issue 1/2007
Electronic ISSN: 1750-1164
DOI: https://doi.org/10.1186/1750-1164-1-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Non-invasive MR imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm: a case report

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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