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Chinese Medicine
Published in: Chinese Medicine 1/2014

Open Access 01-12-2014 | Research

Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology

Authors: Leihong Wu, Yi Wang, Zheng Li, Boli Zhang, Yiyu Cheng, Xiaohui Fan

Published in: Chinese Medicine | Issue 1/2014

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Abstract

Background

The role of “Jun-Chen-Zuo-Shi” (also known as “sovereign-minister-assistant-courier”) component herbs of Chinese medicine is not fully understood. This study aims to test the “Jun-Chen-Zuo-Shi” rule with the QiShenYiQi formula (QSYQ) on treating acute myocardial ischemia (AMI) by a network pharmacology approach.

Methods

An Acute Myocardial Ischemia (AMI) specific Organism Disturbed Network (AMI-ODN), was constructed by integrating data of disease-associated genes, protein-protein interaction and microarray experiments. A network-based index, Network Recovery Index for Organism Disturbed Network (NRI-ODN), was developed to measure the therapeutic efficacy of QSYQ and its ingredients, i.e., the ability to recover disturbed AMI network model back to normal state.

Results

The whole formula of QSYQ got a NRI-ODN score of 864.48, which outperformed all individual herbs. Additionally, the primary component herbs, Radix Astragalus membranaceus and Radix Salvia miltiorrrhiza showed NRI-DON score of 680.27 and 734.31 respectively, which meant a better performance to recover disturbed AMI network than the supplementary component herbs, Panax notoginseng and Dalbergia sissoo did (545.76 and 584.88, respectively).

Conclusion

AMI-ODN model and NRI-ODN identified the possible roles of “Jun-Chen-Zuo-Shi” component herbs of QSYQ in treating AMI at molecular network and pathway level.
Appendix
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Metadata
Title
Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology
Authors
Leihong Wu
Yi Wang
Zheng Li
Boli Zhang
Yiyu Cheng
Xiaohui Fan
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2014
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-9-24

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