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Chinese Medicine
Published in: Chinese Medicine 1/2011

Open Access 01-12-2011 | Review

Recent advances in nanoparticle formulation of oleanolic acid

Authors: Meiwan Chen, Zhangfeng Zhong, Wen Tan, Shengpeng Wang, Yitao Wang

Published in: Chinese Medicine | Issue 1/2011

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Abstract

Oleanolic acid (OA) is a natural triterpenoid possessing anti-inflammatory, antitumor, antiviral, hepatoprotective and antihyperlipidemic effects. Research on the pharmacological activities and clinical applications of OA has made significant progress in the past decade, particularly in the areas such as isolation and purification, chemical modifications, pharmacological research, toxicity studies and clinical use of OA. However, due to its poor aqueous solubility, instability and low bioavailability, OA's clinical applications are still rather limited. Recently, nanoparticulate drug delivery as the biological dimension of nanotechnology has been developed, which may help generate useful formulations of OA for clinical applications. Nanoparticulate drug delivery system enhances the dissolution rate and bioavailability of OA, providing a feasible formulation method for clinical applications.
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Metadata
Title
Recent advances in nanoparticle formulation of oleanolic acid
Authors
Meiwan Chen
Zhangfeng Zhong
Wen Tan
Shengpeng Wang
Yitao Wang
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2011
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/1749-8546-6-20

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