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Published in: Journal of Cardiothoracic Surgery 1/2013

Open Access 01-12-2013 | Research article

Intestinal ischemia after cardiac surgery: analysis of a large registry

Authors: Johan Nilsson, Erika Hansson, Bodil Andersson

Published in: Journal of Cardiothoracic Surgery | Issue 1/2013

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Abstract

Background

Intestinal ischemia after cardiac surgery is a rare but severe complication with a high mortality. Early surgery can be lifesaving. The aim was to analyze the incidence, outcome, and risk factors for these patients.

Methods

A prospectively collected database with patients who underwent 18,879 cardiac surgical procedures between 1996 and 2011 was investigated. All patients with registered gastrointestinal complications were retrospectively reviewed. Univariate and multivariate analyses were performed to compare patients with and without intestinal ischemia.

Results

Seventeen patients suffered from intestinal ischemia (0.09%), 10 of whom (59%) died. By investigating preoperative parameters independent risk factors were steroids, peripheral vascular disease, cardiogenic shock, and New York Heart Association class 4. When including pre-, per-, and postoperative parameters, only postoperative ones were significant, including elevated creatinine (> 200 μmol/L), prolonged ventilator time, need for intra-aortic balloon pump, and cerebrovascular insult (CVI). The gastrointestinal complications score (GICS) showed a ROC area of 0.87. This was superior compared with EuroSCORE (0.74), to predict intestinal ischemia.

Conclusions

Intestinal ischemia after cardiac surgery is more common in patients with a poor cardiac state, but the use of steroids, peripheral vascular disease, postoperative kidney failure, and CVI were also predictive. GICS score, developed for all GI complications after cardiac surgery, is also of value in predicting this particular complication. The risk factors presented can be used as an aid in the diagnosis of these patients.
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Literature
1.
go back to reference Andersson B, Nilsson J, Brandt J, Hoglund P, Andersson R: Gastrointestinal complications after cardiac surgery. Br J Surg. 2005, 92: 326-333. 10.1002/bjs.4823.CrossRefPubMed Andersson B, Nilsson J, Brandt J, Hoglund P, Andersson R: Gastrointestinal complications after cardiac surgery. Br J Surg. 2005, 92: 326-333. 10.1002/bjs.4823.CrossRefPubMed
2.
go back to reference Christenson JT, Schmuziger M, Maurice J, Simonet F, Velebit V: Postoperative visceral hypotension the common cause for gastrointestinal complications after cardiac surgery. Thorac Cardiovasc Surg. 1994, 42: 152-157. 10.1055/s-2007-1016478.CrossRefPubMed Christenson JT, Schmuziger M, Maurice J, Simonet F, Velebit V: Postoperative visceral hypotension the common cause for gastrointestinal complications after cardiac surgery. Thorac Cardiovasc Surg. 1994, 42: 152-157. 10.1055/s-2007-1016478.CrossRefPubMed
3.
go back to reference Abboud B, Daher R, Sleilaty G, Madi-Jebara S, El Asmar B, Achouch R, Jebara V: Is prompt exploratory laparotomy the best attitude for mesenteric ischemia after cardiac surgery?. Interact Cardiovasc Thorac Surg. 2008, 7: 1079-1083. 10.1510/icvts.2008.176271.CrossRefPubMed Abboud B, Daher R, Sleilaty G, Madi-Jebara S, El Asmar B, Achouch R, Jebara V: Is prompt exploratory laparotomy the best attitude for mesenteric ischemia after cardiac surgery?. Interact Cardiovasc Thorac Surg. 2008, 7: 1079-1083. 10.1510/icvts.2008.176271.CrossRefPubMed
4.
go back to reference Albes JM, Schistek R, Baier R, Unger F: Intestinal ischemia associated with cardio-pulmonary-bypass surgery: a life threatening complication. J Cardiovasc Surg (Torino). 1991, 32: 527-533. Albes JM, Schistek R, Baier R, Unger F: Intestinal ischemia associated with cardio-pulmonary-bypass surgery: a life threatening complication. J Cardiovasc Surg (Torino). 1991, 32: 527-533.
5.
go back to reference Ghosh S, Roberts N, Firmin RK, Jameson J, Spyt TJ: Risk factors for intestinal ischaemia in cardiac surgical patients. Eur J Cardiothorac Surg. 2002, 21: 411-416. 10.1016/S1010-7940(02)00015-5.CrossRefPubMed Ghosh S, Roberts N, Firmin RK, Jameson J, Spyt TJ: Risk factors for intestinal ischaemia in cardiac surgical patients. Eur J Cardiothorac Surg. 2002, 21: 411-416. 10.1016/S1010-7940(02)00015-5.CrossRefPubMed
6.
go back to reference Byhahn C, Strouhal U, Martens S, Mierdl S, Kessler P, Westphal K: Incidence of gastrointestinal complications in cardiopulmonary bypass patients. World J Surg. 2001, 25: 1140-1144. 10.1007/BF03215861.CrossRefPubMed Byhahn C, Strouhal U, Martens S, Mierdl S, Kessler P, Westphal K: Incidence of gastrointestinal complications in cardiopulmonary bypass patients. World J Surg. 2001, 25: 1140-1144. 10.1007/BF03215861.CrossRefPubMed
7.
go back to reference Mangi AA, Christison-Lagay ER, Torchiana DF, Warshaw AL, Berger DL: Gastrointestinal complications in patients undergoing heart operation: an analysis of 8709 consecutive cardiac surgical patients. Ann Surg. 2005, 241: 895-901. 10.1097/01.sla.0000164173.05762.32. discussion 901–4CrossRefPubMedPubMedCentral Mangi AA, Christison-Lagay ER, Torchiana DF, Warshaw AL, Berger DL: Gastrointestinal complications in patients undergoing heart operation: an analysis of 8709 consecutive cardiac surgical patients. Ann Surg. 2005, 241: 895-901. 10.1097/01.sla.0000164173.05762.32. discussion 901–4CrossRefPubMedPubMedCentral
8.
go back to reference Filsoufi F, Rahmanian PB, Castillo JG, Scurlock C, Legnani PE, Adams DH: Predictors and outcome of gastrointestinal complications in patients undergoing cardiac surgery. Ann Surg. 2007, 246: 323-329. 10.1097/SLA.0b013e3180603010.CrossRefPubMedPubMedCentral Filsoufi F, Rahmanian PB, Castillo JG, Scurlock C, Legnani PE, Adams DH: Predictors and outcome of gastrointestinal complications in patients undergoing cardiac surgery. Ann Surg. 2007, 246: 323-329. 10.1097/SLA.0b013e3180603010.CrossRefPubMedPubMedCentral
9.
go back to reference Andersson B, Andersson R, Brandt J, Hoglund P, Algotsson L, Nilsson J: Gastrointestinal complications after cardiac surgery - improved risk stratification using a new scoring model. Interact Cardiovasc Thorac Surg. 2010, 10: 366-370. 10.1510/icvts.2009.219113.CrossRefPubMed Andersson B, Andersson R, Brandt J, Hoglund P, Algotsson L, Nilsson J: Gastrointestinal complications after cardiac surgery - improved risk stratification using a new scoring model. Interact Cardiovasc Thorac Surg. 2010, 10: 366-370. 10.1510/icvts.2009.219113.CrossRefPubMed
10.
go back to reference Chaudhuri N, James J, Sheikh A, Grayson AD, Fabri BM: Intestinal ischaemia following cardiac surgery: a multivariate risk model. Eur J Cardiothorac Surg. 2006, 29: 971-977. 10.1016/j.ejcts.2006.03.014.CrossRefPubMed Chaudhuri N, James J, Sheikh A, Grayson AD, Fabri BM: Intestinal ischaemia following cardiac surgery: a multivariate risk model. Eur J Cardiothorac Surg. 2006, 29: 971-977. 10.1016/j.ejcts.2006.03.014.CrossRefPubMed
11.
go back to reference Pang PY, Sin YK, Lim CH, Su JW, Chua YL: Outcome and survival analysis of intestinal ischaemia following cardiac surgery. Interact Cardiovasc Thorac Surg. 2012, 15: 215-218. 10.1093/icvts/ivs181.CrossRefPubMedPubMedCentral Pang PY, Sin YK, Lim CH, Su JW, Chua YL: Outcome and survival analysis of intestinal ischaemia following cardiac surgery. Interact Cardiovasc Thorac Surg. 2012, 15: 215-218. 10.1093/icvts/ivs181.CrossRefPubMedPubMedCentral
12.
go back to reference Huwer H, Winning J, Straub U, Isringhaus H, Kalweit G: Clinically diagnosed nonocclusive mesenteric ischemia after cardiopulmonary bypass: retrospective study. Vascular. 2004, 12: 114-120. 10.2310/6670.2004.20769.CrossRefPubMed Huwer H, Winning J, Straub U, Isringhaus H, Kalweit G: Clinically diagnosed nonocclusive mesenteric ischemia after cardiopulmonary bypass: retrospective study. Vascular. 2004, 12: 114-120. 10.2310/6670.2004.20769.CrossRefPubMed
13.
go back to reference Ende N: Infarction of the bowel in cardiac failure. N Engl J Med. 1958, 258: 879-881. 10.1056/NEJM195805012581804.CrossRefPubMed Ende N: Infarction of the bowel in cardiac failure. N Engl J Med. 1958, 258: 879-881. 10.1056/NEJM195805012581804.CrossRefPubMed
14.
go back to reference Kazui T, Yamasaki M, Abe K, Watanabe S, Kawazoe K: Non-obstructive mesenteric ischemia: a potentially lethal complication after cardiovascular surgery: report of two cases. Ann Thorac Cardiovasc Surg. 2012, 18: 56-60. 10.5761/atcs.cr.10.01654.CrossRefPubMed Kazui T, Yamasaki M, Abe K, Watanabe S, Kawazoe K: Non-obstructive mesenteric ischemia: a potentially lethal complication after cardiovascular surgery: report of two cases. Ann Thorac Cardiovasc Surg. 2012, 18: 56-60. 10.5761/atcs.cr.10.01654.CrossRefPubMed
15.
go back to reference Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R: European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999, 16: 9-13. 10.1016/S1010-7940(99)00134-7.CrossRefPubMed Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R: European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999, 16: 9-13. 10.1016/S1010-7940(99)00134-7.CrossRefPubMed
16.
go back to reference DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307/2531595.CrossRefPubMed DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307/2531595.CrossRefPubMed
17.
go back to reference Schemper M, Smith TL: Efficient evaluation of treatment effects in the presence of missing covariate values. Stat Med. 1990, 9: 777-784. 10.1002/sim.4780090707.CrossRefPubMed Schemper M, Smith TL: Efficient evaluation of treatment effects in the presence of missing covariate values. Stat Med. 1990, 9: 777-784. 10.1002/sim.4780090707.CrossRefPubMed
18.
go back to reference Allen KB, Salam AA, Lumsden AB: Acute mesenteric ischemia after cardiopulmonary bypass. J Vasc Surg. 1992, 16: 391-395. discussion 395–6CrossRefPubMed Allen KB, Salam AA, Lumsden AB: Acute mesenteric ischemia after cardiopulmonary bypass. J Vasc Surg. 1992, 16: 391-395. discussion 395–6CrossRefPubMed
19.
go back to reference Garofalo M, Borioni R, Nardi P, Turani F, Bertoldo F, Forlani S, Pellegrino A, Chiariello L: Early diagnosis of acute mesenteric ischemia after cardiopulmonary bypass. J Cardiovasc Surg (Torino). 2002, 43: 455-459. Garofalo M, Borioni R, Nardi P, Turani F, Bertoldo F, Forlani S, Pellegrino A, Chiariello L: Early diagnosis of acute mesenteric ischemia after cardiopulmonary bypass. J Cardiovasc Surg (Torino). 2002, 43: 455-459.
20.
go back to reference Klotz S, Vestring T, Rotker J, Schmidt C, Scheld HH, Schmid C: Diagnosis and treatment of nonocclusive mesenteric ischemia after open heart surgery. Ann Thorac Surg. 2001, 72: 1583-1586. 10.1016/S0003-4975(01)03179-4.CrossRefPubMed Klotz S, Vestring T, Rotker J, Schmidt C, Scheld HH, Schmid C: Diagnosis and treatment of nonocclusive mesenteric ischemia after open heart surgery. Ann Thorac Surg. 2001, 72: 1583-1586. 10.1016/S0003-4975(01)03179-4.CrossRefPubMed
21.
go back to reference Spotnitz WD, Sanders RP, Hanks JB, Nolan SP, Tribble CG, Bergin JD, Zacour RK, Abbott RD, Kron IL: General surgical complications can be predicted after cardiopulmonary bypass. Ann Surg. 1995, 221: 489-496. 10.1097/00000658-199505000-00006. discussion 496–7CrossRefPubMedPubMedCentral Spotnitz WD, Sanders RP, Hanks JB, Nolan SP, Tribble CG, Bergin JD, Zacour RK, Abbott RD, Kron IL: General surgical complications can be predicted after cardiopulmonary bypass. Ann Surg. 1995, 221: 489-496. 10.1097/00000658-199505000-00006. discussion 496–7CrossRefPubMedPubMedCentral
22.
go back to reference D'Ancona G, Baillot R, Poirier B, Dagenais F, de Ibarra JI, Bauset R, Mathieu P, Doyle D: Determinants of gastrointestinal complications in cardiac surgery. Tex Heart Inst J. 2003, 30: 280-285.PubMedPubMedCentral D'Ancona G, Baillot R, Poirier B, Dagenais F, de Ibarra JI, Bauset R, Mathieu P, Doyle D: Determinants of gastrointestinal complications in cardiac surgery. Tex Heart Inst J. 2003, 30: 280-285.PubMedPubMedCentral
23.
go back to reference Hasan S, Ratnatunga C, Lewis CT, Pillai R: Gut ischaemia following cardiac surgery. Interact Cardiovasc Thorac Surg. 2004, 3: 475-478. 10.1016/j.icvts.2004.04.003.CrossRefPubMed Hasan S, Ratnatunga C, Lewis CT, Pillai R: Gut ischaemia following cardiac surgery. Interact Cardiovasc Thorac Surg. 2004, 3: 475-478. 10.1016/j.icvts.2004.04.003.CrossRefPubMed
24.
go back to reference Hackert T, Kienle P, Weitz J, Werner J, Szabo G, Hagl S, Buchler MW, Schmidt J: Accuracy of diagnostic laparoscopy for early diagnosis of abdominal complications after cardiac surgery. Surg Endosc. 2003, 17: 1671-1674. 10.1007/s00464-003-9004-1.CrossRefPubMed Hackert T, Kienle P, Weitz J, Werner J, Szabo G, Hagl S, Buchler MW, Schmidt J: Accuracy of diagnostic laparoscopy for early diagnosis of abdominal complications after cardiac surgery. Surg Endosc. 2003, 17: 1671-1674. 10.1007/s00464-003-9004-1.CrossRefPubMed
25.
go back to reference Niederhauser U, Genoni M, von Segesser LK, Bruhlmann W, Turina MI: Mesenteric ischemia after a cardiac operation: conservative treatment with local vasodilation. Ann Thorac Surg. 1996, 61: 1817-1819. 10.1016/0003-4975(95)01198-6.CrossRefPubMed Niederhauser U, Genoni M, von Segesser LK, Bruhlmann W, Turina MI: Mesenteric ischemia after a cardiac operation: conservative treatment with local vasodilation. Ann Thorac Surg. 1996, 61: 1817-1819. 10.1016/0003-4975(95)01198-6.CrossRefPubMed
26.
go back to reference Groesdonk HV, Klingele M, Schlempp S, Bomberg H, Schmied W, Minko P, Schafers HJ: Risk factors for nonocclusive mesenteric ischemia after elective cardiac surgery. J Thorac Cardiovasc Surg. 2013, 145: 1603-1610. 10.1016/j.jtcvs.2012.11.022.CrossRefPubMed Groesdonk HV, Klingele M, Schlempp S, Bomberg H, Schmied W, Minko P, Schafers HJ: Risk factors for nonocclusive mesenteric ischemia after elective cardiac surgery. J Thorac Cardiovasc Surg. 2013, 145: 1603-1610. 10.1016/j.jtcvs.2012.11.022.CrossRefPubMed
27.
go back to reference Edwards M, Sidebotham D, Smith M, Leemput JV, Anderson B: Diagnosis and outcome from suspected mesenteric ischaemia following cardiac surgery. Anaesth Intensive Care. 2005, 33: 210-217.PubMed Edwards M, Sidebotham D, Smith M, Leemput JV, Anderson B: Diagnosis and outcome from suspected mesenteric ischaemia following cardiac surgery. Anaesth Intensive Care. 2005, 33: 210-217.PubMed
28.
go back to reference Demir IE, Ceyhan GO, Friess H: Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia?. Dig Surg. 2012, 29: 226-235. 10.1159/000338086.CrossRefPubMed Demir IE, Ceyhan GO, Friess H: Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia?. Dig Surg. 2012, 29: 226-235. 10.1159/000338086.CrossRefPubMed
29.
go back to reference Fitzgerald T, Kim D, Karakozis S, Alam H, Provido H, Kirkpatrick J: Visceral ischemia after cardiopulmonary bypass. Am Surg. 2000, 66: 623-626.PubMed Fitzgerald T, Kim D, Karakozis S, Alam H, Provido H, Kirkpatrick J: Visceral ischemia after cardiopulmonary bypass. Am Surg. 2000, 66: 623-626.PubMed
Metadata
Title
Intestinal ischemia after cardiac surgery: analysis of a large registry
Authors
Johan Nilsson
Erika Hansson
Bodil Andersson
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2013
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/1749-8090-8-156

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