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Published in: Journal of Cardiothoracic Surgery 1/2012

Open Access 01-12-2012 | Letters to the Editor

Development of post-pericardiotomy syndrome is preceded by an increase in pro-inflammatory and a decrease in anti-inflammatory serological markers

Authors: Nora Snefjellå, Knut Tore Lappegård

Published in: Journal of Cardiothoracic Surgery | Issue 1/2012

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Abstract

The post-pericardiotomy syndrome (PPS) is a common complication after cardiac surgery, occuring in 10-40% of patients. PPS may prolong hospitalization, and even serious complications like tamponade and constrictive pericarditis may occur. Early diagnosis and treatment may reduce morbidity. In 50 patients transferred to our hospital after cardiac surgery we found an increase in pro-inflammatory and a decrease in anti-inflammatory cytokines at admission in the patients later developing PPS compared to the patients who did not develop PPS. If confirmed in larger studies, these findings may prove useful in early identification of and targeted treatment in patients developing PPS.
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Literature
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go back to reference Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE: The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent. J Biomed Mater Res A. 2008, 87: 129-135.CrossRefPubMedPubMedCentral Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE: The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent. J Biomed Mater Res A. 2008, 87: 129-135.CrossRefPubMedPubMedCentral
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go back to reference Imazio M, Trinchero R, Brucato A, Rovere ME, Gandino A, Cemin R: COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. Eur Heart J. 2010, 31: 2749-2754. 10.1093/eurheartj/ehq319.CrossRefPubMed Imazio M, Trinchero R, Brucato A, Rovere ME, Gandino A, Cemin R: COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. Eur Heart J. 2010, 31: 2749-2754. 10.1093/eurheartj/ehq319.CrossRefPubMed
Metadata
Title
Development of post-pericardiotomy syndrome is preceded by an increase in pro-inflammatory and a decrease in anti-inflammatory serological markers
Authors
Nora Snefjellå
Knut Tore Lappegård
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2012
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/1749-8090-7-72

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