Skip to main content
Top
Published in: Journal of Orthopaedic Surgery and Research 1/2008

Open Access 01-12-2008 | Research article

Comparison of prognostic scores and surgical approaches to treat spinal metastatic tumors: A review of 57 cases

Authors: Selcuk Yilmazlar, Seref Dogan, Basak Caner, Alper Turkkan, Ahmet Bekar, Ender Korfali

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2008

Login to get access

Abstract

Surgical treatment of metastatic spinal cord compression with or without neural deficit is controversial. Karnofsky and Tokuhashi scores have been proposed for prognosis of spinal metastasis. Here, we conducted a retrospective analysis of Karnofsky and modified Tokuhashi scores in 57 consecutive patients undergoing surgery for secondary spinal metastases to evaluate the value of these scores in aiding decision making for surgery. Comparison of preoperative Karnofsky and modified Tokuhashi scores with the type of the surgical approach for each patient revealed that both scores not only reliably estimate life expectancy, but also objectively improved surgical decisions. When the general status of the patient is poor (i.e., Karnofsky score less than 40% or modified Tokuhashi score of 5 or greater), palliative treatments and radiotherapy, rather than surgery, should be considered.
Literature
1.
go back to reference Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S: Scoring system for the preoperative evaluation of metastatic spine tumour prognosis. Spine. 1990, 15: 1110-13. 10.1097/00007632-199011010-00005.CrossRefPubMed Tokuhashi Y, Matsuzaki H, Toriyama S, Kawano H, Ohsaka S: Scoring system for the preoperative evaluation of metastatic spine tumour prognosis. Spine. 1990, 15: 1110-13. 10.1097/00007632-199011010-00005.CrossRefPubMed
2.
go back to reference Ulmar B, Naumann U, Catalkaya S, Muche R, Cakir B, Schmidt R, Reichel H, Huch K: Prognosis scores of Tokuhashi and Tomita for patients with spinal metastases of renal cancer. Ann Surg Oncol. 2007, 14 (2): 998-1004. 10.1245/s10434-006-9000-5. Epub 2006 Nov 3CrossRefPubMed Ulmar B, Naumann U, Catalkaya S, Muche R, Cakir B, Schmidt R, Reichel H, Huch K: Prognosis scores of Tokuhashi and Tomita for patients with spinal metastases of renal cancer. Ann Surg Oncol. 2007, 14 (2): 998-1004. 10.1245/s10434-006-9000-5. Epub 2006 Nov 3CrossRefPubMed
3.
go back to reference Ulmar B, Richter M, Cakir B, Muche R, Puhl W, Huch K: The Tokuhashi score: significant predictive value for the life expectancy of patients with breast cancer with spinal metastases. Spine. 2005, 30 (19): 2222-6. 10.1097/01.brs.0000181055.10977.5b.CrossRefPubMed Ulmar B, Richter M, Cakir B, Muche R, Puhl W, Huch K: The Tokuhashi score: significant predictive value for the life expectancy of patients with breast cancer with spinal metastases. Spine. 2005, 30 (19): 2222-6. 10.1097/01.brs.0000181055.10977.5b.CrossRefPubMed
4.
go back to reference Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J: Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methylmethacrylate at clinical follow-up. Radiology. 1996, 200: 525-30.CrossRefPubMed Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J: Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methylmethacrylate at clinical follow-up. Radiology. 1996, 200: 525-30.CrossRefPubMed
5.
go back to reference Boland PJ, Lane JM, Sundaresan N: Metastatic disease of the spine. Clin Orthop. 1982, 169: 95-102.PubMed Boland PJ, Lane JM, Sundaresan N: Metastatic disease of the spine. Clin Orthop. 1982, 169: 95-102.PubMed
6.
go back to reference Onimus M, Papin P, Gangloff S, Laurain JM: Résultats du traitement chirurgical des métastases vertébrales dorsales et lombaires. Rachis. 1995, 7: 275-82. Onimus M, Papin P, Gangloff S, Laurain JM: Résultats du traitement chirurgical des métastases vertébrales dorsales et lombaires. Rachis. 1995, 7: 275-82.
7.
go back to reference Bridwell KH, Jenny AB, Saul T, Rich KM, Grubb RL: Posterior spinal instrumentation with posterolateral decompression and debulking for metastatic thoracic and lumbar spine disease. Limitations of the technique. Spine. 1988, 13: 1383-94. 10.1097/00007632-198812000-00010.CrossRefPubMed Bridwell KH, Jenny AB, Saul T, Rich KM, Grubb RL: Posterior spinal instrumentation with posterolateral decompression and debulking for metastatic thoracic and lumbar spine disease. Limitations of the technique. Spine. 1988, 13: 1383-94. 10.1097/00007632-198812000-00010.CrossRefPubMed
8.
go back to reference Karnofsky DA: Clinical evaluation of anticancer drugs: cancer chemotherapy. Gann Monogr. 1967, 2: 223-31. Karnofsky DA: Clinical evaluation of anticancer drugs: cancer chemotherapy. Gann Monogr. 1967, 2: 223-31.
9.
go back to reference Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J: A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine. 2005, 1;30 (19): 2186-91. 10.1097/01.brs.0000180401.06919.a5.CrossRef Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J: A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine. 2005, 1;30 (19): 2186-91. 10.1097/01.brs.0000180401.06919.a5.CrossRef
10.
go back to reference Enkaoua EA, Doursounian L, Chatellier G, Mabesoone F, Aimard T, Saillant G: Vertebral metastases: a critical appreciation of the preoperative prognostic Tokuhashi score in a series of 71 cases. Spine. 1997, 1;22 (19): 2293-8. 10.1097/00007632-199710010-00020.CrossRef Enkaoua EA, Doursounian L, Chatellier G, Mabesoone F, Aimard T, Saillant G: Vertebral metastases: a critical appreciation of the preoperative prognostic Tokuhashi score in a series of 71 cases. Spine. 1997, 1;22 (19): 2293-8. 10.1097/00007632-199710010-00020.CrossRef
11.
go back to reference Sundaresan N, Sachdev VP, Holland JF, Moore F, Sung M, Paciucci PA, Wu LT, Kelligher K, Hough L: Surgical treatment of spinal cord compression from epidural metastasis. J Clin Oncol. 1995, 13 (9): 2330-5.PubMed Sundaresan N, Sachdev VP, Holland JF, Moore F, Sung M, Paciucci PA, Wu LT, Kelligher K, Hough L: Surgical treatment of spinal cord compression from epidural metastasis. J Clin Oncol. 1995, 13 (9): 2330-5.PubMed
12.
go back to reference Zarzycki D, Tesiorowski M, Jasiewicz B, Lipik E, Kacki W: Indications and range of surgery in the treatment of spine metastatic tumours. Ortop Traumatol Rehabil. 2003, 5 (2): 172-9.PubMed Zarzycki D, Tesiorowski M, Jasiewicz B, Lipik E, Kacki W: Indications and range of surgery in the treatment of spine metastatic tumours. Ortop Traumatol Rehabil. 2003, 5 (2): 172-9.PubMed
13.
go back to reference Taneichi H, Kaneda K, Takeda N, Abumi K, Satoh S: Risk factors and probability of vertebral body collapse in metastases of thoracic and lumbar spine. Spine. 1997, 22: 239-45. 10.1097/00007632-199702010-00002.CrossRefPubMed Taneichi H, Kaneda K, Takeda N, Abumi K, Satoh S: Risk factors and probability of vertebral body collapse in metastases of thoracic and lumbar spine. Spine. 1997, 22: 239-45. 10.1097/00007632-199702010-00002.CrossRefPubMed
14.
go back to reference North RB, LaRocca VR, Schwartz J, North CA, Zahurak M, Davis RF, McAfee PC: Surgical management of spinal metastases: analysis of prognostic factors during a 10-year experience. J Neurosurg Spine. 2005, 2: 564-73.CrossRefPubMed North RB, LaRocca VR, Schwartz J, North CA, Zahurak M, Davis RF, McAfee PC: Surgical management of spinal metastases: analysis of prognostic factors during a 10-year experience. J Neurosurg Spine. 2005, 2: 564-73.CrossRefPubMed
15.
go back to reference Zou XN, Grejs A, Li HS, Høy K, Hansen ES, Bünger C: Estimation of life expectancy for selecting surgical procedure and predicting prognosis of extradural spinal metastases Ai Zheng. Ai Zheng. 2006, 25 (11): 1406-10. (Abstract)PubMed Zou XN, Grejs A, Li HS, Høy K, Hansen ES, Bünger C: Estimation of life expectancy for selecting surgical procedure and predicting prognosis of extradural spinal metastases Ai Zheng. Ai Zheng. 2006, 25 (11): 1406-10. (Abstract)PubMed
16.
go back to reference Hoskin PJ: Radiotherapy in the management of bone pain. Clin Orthop. 1995, 312: 105-19.PubMed Hoskin PJ: Radiotherapy in the management of bone pain. Clin Orthop. 1995, 312: 105-19.PubMed
17.
go back to reference Schocker JD, Brady LW: Radiation therapy for bone metastasis. Clin Orthop. 1982, 169: 38-43.PubMed Schocker JD, Brady LW: Radiation therapy for bone metastasis. Clin Orthop. 1982, 169: 38-43.PubMed
18.
go back to reference Agarawal JP, Swangsilpa T, Linden van der Y, Rades D, Jeremic B, Hoskin PJ: The role of external beam radiotherapy in the management of bone metastases. Clin Oncol (R Coll Radiol). 2006, 18: 747-60.CrossRef Agarawal JP, Swangsilpa T, Linden van der Y, Rades D, Jeremic B, Hoskin PJ: The role of external beam radiotherapy in the management of bone metastases. Clin Oncol (R Coll Radiol). 2006, 18: 747-60.CrossRef
19.
go back to reference Chataigner H, Onimus M: Surgery in spinal metastasis without spinal cord compression: indications and strategy related to the risk of recurrence. Eur Spine J. 2000, 9: 523-7. 10.1007/s005860000163.PubMedCentralCrossRefPubMed Chataigner H, Onimus M: Surgery in spinal metastasis without spinal cord compression: indications and strategy related to the risk of recurrence. Eur Spine J. 2000, 9: 523-7. 10.1007/s005860000163.PubMedCentralCrossRefPubMed
Metadata
Title
Comparison of prognostic scores and surgical approaches to treat spinal metastatic tumors: A review of 57 cases
Authors
Selcuk Yilmazlar
Seref Dogan
Basak Caner
Alper Turkkan
Ahmet Bekar
Ender Korfali
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2008
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/1749-799X-3-37

Other articles of this Issue 1/2008

Journal of Orthopaedic Surgery and Research 1/2008 Go to the issue